2020
DOI: 10.1038/s41398-020-00958-4
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Molecular linkage between post-traumatic stress disorder and cognitive impairment: a targeted proteomics study of World Trade Center responders

Abstract: Existing work on proteomics has found common biomarkers that are altered in individuals with post-traumatic stress disorder (PTSD) and mild cognitive impairment (MCI). The current study expands our understanding of these biomarkers by profiling 276 plasma proteins with known involvement in neurobiological processes using the Olink Proseek Multiplex Platform in individuals with both PTSD and MCI compared to either disorder alone and with unaffected controls. Participants were World Trade Center (WTC) responders… Show more

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Cited by 22 publications
(30 citation statements)
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“…Indeed, studies have documented disruptions in white matter connectivity and integrity in trauma and PTSD populations [ 119 124 ], which has been proposed to have an underlying etiology due to increased neuroinflammation due to psychosocial stress [ 125 132 ], with accelerated brain senescence [ 133 135 ], and that normal brain aging is associated with reduced cortical complexity [ 39 , 58 – 61 ]. Coupled with our own studies that have identified increased neuroinflammation in responders with chronic WTC-PTSD [ 68 , 136 138 ], we therefore propose that one possible avenue for the reduced cortical complexity observed in WTC responders with chronic PTSD in this study may be due to increased neuroinflammation from elevated psychosocial stress, which may have led to white matter atrophy, in turn leading to reduced cortical complexity through retraction of axonal tension. Future studies with WTC responders and other trauma affected populations should directly interrogate FD analysis, and if possible, integrate diffusion tensor imaging analyses of white matter integrity from MRI, along with concurrent Positron Emission Tomography (PET) biomarkers of neuroinflammation, such as the Translocator protein 18-kDa (TSPO) ligand FEPPA, or others.…”
Section: Discussionsupporting
confidence: 78%
“…Indeed, studies have documented disruptions in white matter connectivity and integrity in trauma and PTSD populations [ 119 124 ], which has been proposed to have an underlying etiology due to increased neuroinflammation due to psychosocial stress [ 125 132 ], with accelerated brain senescence [ 133 135 ], and that normal brain aging is associated with reduced cortical complexity [ 39 , 58 – 61 ]. Coupled with our own studies that have identified increased neuroinflammation in responders with chronic WTC-PTSD [ 68 , 136 138 ], we therefore propose that one possible avenue for the reduced cortical complexity observed in WTC responders with chronic PTSD in this study may be due to increased neuroinflammation from elevated psychosocial stress, which may have led to white matter atrophy, in turn leading to reduced cortical complexity through retraction of axonal tension. Future studies with WTC responders and other trauma affected populations should directly interrogate FD analysis, and if possible, integrate diffusion tensor imaging analyses of white matter integrity from MRI, along with concurrent Positron Emission Tomography (PET) biomarkers of neuroinflammation, such as the Translocator protein 18-kDa (TSPO) ligand FEPPA, or others.…”
Section: Discussionsupporting
confidence: 78%
“…Probable PTSD and MCI were measured by Post-Traumatic Stress Disorder Checklist-Specific Version (PCL-17) and MoCA, respectively. The study identified 50 proteins that could serve as potential protein biomarkers for PTSD, MCI and comorbid PTSD-MCI [ 102 ]. Of these, 16 were associated with comorbid PTSD-MCI, 24 with PTSD-only, and 20 proteins with MCI-only.…”
Section: Resultsmentioning
confidence: 99%
“…To the best of our knowledge, plasma levels of BCAN and Nr-CAM have not been previously investigated in a stroke cohort, but others have used the same protein panel as us in search of plasma biomarkers of other central nervous system (CNS) phenotypes. It is interesting to note that BCAN has been among the top panel candidates for association to healthier white matter, brain volume and cognitive function 21 , 55 , 56 , indicating BCAN as a marker with capacity to reflect these traits in blood. In our study, the difference in BCAN levels between cases and controls was most pronounced in the acute phase, but remained at 3 months.…”
Section: Discussionmentioning
confidence: 99%