Molecular Logic with a Saccharide Probe on the Few-Molecules Level

Abstract

In this Communication we describe a two-component saccharide probe with logic capability. The combination of a boronic acid-appended viologen and perylene diimide was able to perform a complementary implication/not implication logic function. Fluorescence quenching and recovery with fructose was analyzed with fluorescence correlation spectroscopy on the level of a few molecules of the reporting dye.

Enhanced detection of saccharide using redox capacitor as an electrochemical indicator via a redox-cycling and its molecular logic behavior

“…A typical kind of fluorescent saccharide sensing system which is similar to an IDA has been achieved based on the formation of a ground-state complex between fluorophores such as fluorescent dye [26] or graphene quantum dots [27], and boronic acid appended bipyridinium salts. Based on this result, further design for implementation in sensor array [28] and molecular logic gate [29,30] has been reported.…”

Taking baby steps in molecular logic-based computation

“…ion concentration, ionic strength etc. Schiller 104 translates each serial connection of a chosen logic array expressed exclusively in terms of IMPLICATION gates into an algorithm 5 for pipetting input species into wells containing the molecular IMPLICATION logic device 59 in a microtiter plate, while exploiting the 'universal' or 'complete' nature of the gate pair of IMPLICATION and PASS 0. The 'universal' nature of the NAND or NOR gates are widely exploited in the semiconductor 10 industry during integrated circuit manufacture.…”

A supramolecular keypad lock

“…20,21 Surprisingly, the exploitation of supramolecular host-guest phenomena for the demonstration of keypad lock functions has no precedence in the literature. In recent reports host-guest complexes with cucurbit [7]uril (CB7) and cucurbit [8]uril (CB8) were used to demonstrate the reconfigurable and resettable operation of logic gates in aqueous solution. 22,23 Cucurbiturils have drawn much attention for their very high binding constants of cationic guests (up to 10 17 M À1 ) 24 and their supramolecular application potential with a strong focus on biological and pharmacological contexts, and analytical problems is beginning to reveal.…”

“…[1][2][3] The challenge of achieving the design of molecules that are capable of a predetermined logic operation has received important backup from smart applications of molecular logic gates in sensing, drug delivery, theranostics, and materials chemistry. [4][5][6][7][8][9][10] Among the different logic operations, those that imply a memory function belong to the most demanding ones in terms of their chemical design. 11 This type of logic, known as sequential logic, results in differentiated outputs depending on the input history of the device.…”