Molecular mechanism of curcumin action in signaling pathways: Review of the latest research

Liczbiński, Przemysław; Michałowicz, Jaromir; Bukowska, Bożena

doi:10.1002/ptr.6663

Cited by 114 publications

(87 citation statements)

References 91 publications

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“…Curcumin (diferuloylmethane) is a polyphenolic chemical naturally produced by the turmeric plant ( Curcuma longa ), and is the primary curcuminoid compound found in turmeric spice [ 20 ]. Curcumin has a variety of biological activities, impacting many different cellular pathways [ 21 , 22 ]. Curcumin has shown efficacy in a variety of model systems, including models of cancer [ 23 , 24 , 25 ], inflammation [ 26 ] and wound healing [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Effects of Curcumin on Adenovirus Replication

Jennings

Parks

2020

Microorganisms

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Human adenovirus (HAdV) is a common pathogen that can cause severe morbidity and mortality in certain populations, including pediatric, geriatric, and immunocompromised patients. Unfortunately, there are no approved therapeutics to combat HAdV infections. Curcumin, the primary curcuminoid compound found in turmeric spice, has shown broad activity as an antimicrobial agent, limiting the replication of many different bacteria and viruses. In this study, we evaluated curcumin as an anti-HAdV agent. Treatment of cells in culture with curcumin reduced HAdV replication, gene expression, and virus yield, at concentrations of curcumin that had little effect on cell viability. Thus, curcumin represents a promising class of compounds for further study as potential therapeutics to combat HAdV infection.

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Section: Introductionmentioning

confidence: 99%

Antiviral Effects of Curcumin on Adenovirus Replication

Jennings

Parks

2020

Microorganisms

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“…However, being similar to other antioxidants including vitamin E, vitamin C, and carotenoids, curcumin has been found to show double-edged roles in the level of intracellular ROS, which appeared to be highly dependent on the cell type [30][31][32]. Curcumin has been reported to elevate ROS levels in multiple cancer cells [30][31][32]. In this study, in line with the well-accepted anti-oxidative activity of curcumin in normal and non-malignant cells [29][30][31][32], 4-week exposure of rats to 40 mg/kg ACR markedly enhanced the level of MDA (an essential biomarker of oxidative stress and lipid peroxidation), decreased the content of GSH (a biologically important intracellular thiol acting as a free radical scavenger) and the activities of SOD and GSH-Px (two important antioxidant enzymes) in the brain tissues.…”

Section: Discussionmentioning

confidence: 97%

“…The phenolic structure in curcumin confers electron-capturing properties, which destabilize ROS, explaining the wellaccepted antioxidant effects [30]. However, being similar to other antioxidants including vitamin E, vitamin C, and carotenoids, curcumin has been found to show double-edged roles in the level of intracellular ROS, which appeared to be highly dependent on the cell type [30][31][32]. Curcumin has been reported to elevate ROS levels in multiple cancer cells [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

“…Curcumin has been reported to elevate ROS levels in multiple cancer cells [30][31][32]. In this study, in line with the well-accepted anti-oxidative activity of curcumin in normal and non-malignant cells [29][30][31][32], 4-week exposure of rats to 40 mg/kg ACR markedly enhanced the level of MDA (an essential biomarker of oxidative stress and lipid peroxidation), decreased the content of GSH (a biologically important intracellular thiol acting as a free radical scavenger) and the activities of SOD and GSH-Px (two important antioxidant enzymes) in the brain tissues. But curcumin alleviated the augmented production of MDA and the reduction of antioxidant capacity induced by ACR, thus might play a role in the detoxi cation of reactive oxygen species generated by ACR.…”

Section: Discussionmentioning

confidence: 99%

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The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

Guo

Cao

et al. 2020

Preprint

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Background: Acrylamide (ACR) formed during heating of tobacco and carbohydrate-rich food as well as widely applied in industries has been known as a well-established neurotoxic pollutant. Although the precise mechanism is unclear, enhanced apoptosis, oxidative stress and inflammation have been demonstrated to contribute to the ACR-induced neurotoxicity. In this study, we assessed the possible anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin, the most active component in a popular spice known as turmeric, on the neurotoxicity caused by ACR in rats.Methods: Curcumin at the dose of 50 and 100 mg/kg was orally given to ACR- intoxicated Sprague-Dawley rats exposed by ACR at 40mg/kg for 4 weeks. All rats were subjected to behavioral analysis. The HE staining and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling (TUNEL) staining were used to detect histopathological changes and apoptotic cells, respectively. The mRNA and protein expressions of apoptosis-related molecule telomerase reverse transcriptase (TERT) were detected using real-time PCR and immunohistochemistry, respectively. The contents of malondialdehyde (MDA) and glutathione (GSH) as well as the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured as the indicators for evaluating the level of oxidative stress in brain. The levels of pro-inflammatory cytokinestumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the cerebral homogenates were detected using ELISA assay.Results: ACR-induced weigh loss, deficits in motor function as well as pathological alterations in brains were significantly improved in rats administrated with 50 and 100 mg/kg curcumin. TUNEL-positive apoptotic cells in curcumin-treated ACR intoxicated brains were less than those in the ACR model group. Curcumin administration especially at the dose of 100 mg/kg upregulated the TERT mRNA expression and enhanced the number of TERT-positive cells in ACR-intoxicated cortex tissues. Moreover, curcumin treatment reduced the concentrations of TNF-α, IL-1β and MDA, while increased the GSH contents as well as the SOD and GSH-Px activities in the cerebral homogenates, in comparison to ACR control group.Conclusions: These data suggested the anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on ACR-induced neurotoxicity in rats. Maintaining TERT-related anti-apoptotic function might be one mechanism underlying the protective effect of curcumin on ACR-intoxicated brains.

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“…The phenolic structure in curcumin confers electron-capturing properties, which destabilize ROS, explaining the well-accepted antioxidant effects [30]. However, being similar to other antioxidants including vitamin E, vitamin C, and carotenoids, curcumin has been found to show double-edged roles in the level of intracellular ROS, which appeared to be highly dependent on the cell type [30][31][32]. Curcumin has been reported to elevate ROS levels in multiple cancer cells [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

Guo

Cao

et al. 2020

BMC Pharmacol Toxicol

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Background: Acrylamide (ACR) formed during heating of tobacco and carbohydrate-rich food as well as widely applied in industries has been known as a well-established neurotoxic pollutant. Although the precise mechanism is unclear, enhanced apoptosis, oxidative stress and inflammation have been demonstrated to contribute to the ACRinduced neurotoxicity. In this study, we assessed the possible anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin, the most active component in a popular spice known as turmeric, on the neurotoxicity caused by ACR in rats. Methods: Curcumin at the dose of 50 and 100 mg/kg was orally given to ACR-intoxicated Sprague-Dawley rats exposed by ACR at 40 mg/kg for 4 weeks. All rats were subjected to behavioral analysis. The HE staining and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling (TUNEL) staining were used to detect histopathological changes and apoptotic cells, respectively. The mRNA and protein expressions of apoptosis-related molecule telomerase reverse transcriptase (TERT) were detected using real-time PCR and immunohistochemistry, respectively. The contents of malondialdehyde (MDA) and glutathione (GSH) as well as the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured as the indicators for evaluating the level of oxidative stress in brain. The levels of pro-inflammatory cytokinestumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the cerebral homogenates were detected using ELISA assay. Results: ACR-induced weigh loss, deficits in motor function as well as pathological alterations in brains were significantly improved in rats administrated with 50 and 100 mg/kg curcumin. TUNEL-positive apoptotic cells in curcumin-treated ACR intoxicated brains were less than those in the ACR model group. Curcumin administration especially at the dose of 100 mg/kg upregulated the TERT mRNA expression and enhanced the number of TERTpositive cells in ACR-intoxicated cortex tissues. Moreover, curcumin treatment reduced the concentrations of TNF-α, IL-1β and MDA, while increased the GSH contents as well as the SOD and GSH-Px activities in the cerebral homogenates, in comparison to ACR control group.

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Molecular mechanism of curcumin action in signaling pathways: Review of the latest research

Cited by 114 publications

References 91 publications

Antiviral Effects of Curcumin on Adenovirus Replication

Antiviral Effects of Curcumin on Adenovirus Replication

The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

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