Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles

Hu, Renping; Zheng, Lei; Zhang, Ting; Gao, Guodong; Cui, Yaling; Cheng, Zhe; Cheng, Jie; Hong, Mengmeng; Tang, Meng; Hong, Fashui

doi:10.1016/j.jhazmat.2011.04.027

Cited by 182 publications

(164 citation statements)

References 47 publications

(73 reference statements)

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“…These observations were consistent with another set of research on the toxicity of TiO 2 NPs that was conducted 2 years earlier by Hu et al 75 this research also indicated that TiO 2 NPs induced an accumulation of ROS in the mouse hippocampus. Similar studies of the oxidative stresses that are associated with selective gene expression analyses and immunological biomarkers would further improve our understanding of the mechanisms of neuroinflammation and neurodegeneration associated with NPs.…”

supporting

confidence: 92%

Application of dental nanomaterials: potential toxicity to the central nervous system

Feng¹,

Chen²,

Wang³

et al. 2015

IJN

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Nanomaterials are defined as materials with one or more external dimensions with a size of 1–100 nm. Such materials possess typical nanostructure-dependent properties (eg, chemical, biological, optical, mechanical, and magnetic), which may differ greatly from the properties of their bulk counterparts. In recent years, nanomaterials have been widely used in the production of dental materials, particularly in light polymerization composite resins and bonding systems, coating materials for dental implants, bioceramics, endodontic sealers, and mouthwashes. However, the dental applications of nanomaterials yield not only a significant improvement in clinical treatments but also growing concerns regarding their biosecurity. The brain is well protected by the blood–brain barrier (BBB), which separates the blood from the cerebral parenchyma. However, in recent years, many studies have found that nanoparticles (NPs), including nanocarriers, can transport through the BBB and locate in the central nervous system (CNS). Because the CNS may be a potential target organ of the nanomaterials, it is essential to determine the neurotoxic effects of NPs. In this review, possible dental nanomaterials and their pathways into the CNS are discussed, as well as related neurotoxicity effects underlying the in vitro and in vivo studies. Finally, we analyze the limitations of the current testing methods on the toxicological effects of nanomaterials. This review contributes to a better understanding of the nano-related risks to the CNS as well as the further development of safety assessment systems.

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confidence: 92%

Application of dental nanomaterials: potential toxicity to the central nervous system

Feng¹,

Chen²,

Wang³

et al. 2015

IJN

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“…Another study in mice indicated that TiO 2 NPs accumulate in the mouse hippocampus by intragastric administration, leading to hippocampal apoptosis and impairment in spatial recognition. 11 In vivo studies have shown that the neurotoxic effects of TiO 2 NPs on mice are likely caused by the disturbed homeostasis of trace elements, enzymes, and neurotransmitter systems. 40 In addition, silver NPs have been found to have the ability to induce damage to the BBB and astrocytes and cause neuronal degeneration in rats after subcutaneous injection.…”

Section: Relationship Between Nms and Cns Dysfunctionmentioning

confidence: 99%

Central nervous system toxicity of metallic nanoparticles

Feng¹,

Chen²,

Zhang³

et al. 2015

IJN

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Nanomaterials (NMs) are increasingly used for the therapy, diagnosis, and monitoring of disease- or drug-induced mechanisms in the human biological system. In view of their small size, after certain modifications, NMs have the capacity to bypass or cross the blood–brain barrier. Nanotechnology is particularly advantageous in the field of neurology. Examples may include the utilization of nanoparticle (NP)-based drug carriers to readily cross the blood–brain barrier to treat central nervous system (CNS) diseases, nanoscaffolds for axonal regeneration, nanoelectromechanical systems in neurological operations, and NPs in molecular imaging and CNS imaging. However, NPs can also be potentially hazardous to the CNS in terms of nano-neurotoxicity via several possible mechanisms, such as oxidative stress, autophagy, and lysosome dysfunction, and the activation of certain signaling pathways. In this review, we discuss the dual effect of NMs on the CNS and the mechanisms involved. The limitations of the current research are also discussed.

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“…The details of the synthesis and characterization of TiO 2 NPs were previously described by Yang et al [12] and Hu et al [13], respectively. The average particle size contained in the powder suspended in 0.5% (w/v) hydroxypropylmethylcellulose (HPMC) K4 M solvent after 12 h and 24 h incubation ranged from 5 to 6 nm.…”

Section: Chemicals and Preparationmentioning

confidence: 99%

Pulmotoxicological effects caused by long-term titanium dioxide nanoparticles exposure in mice

Sun

Tan

et al. 2012

Journal of Hazardous Materials

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Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles

Cited by 182 publications

References 47 publications

Application of dental nanomaterials: potential toxicity to the central nervous system

Application of dental nanomaterials: potential toxicity to the central nervous system

Central nervous system toxicity of metallic nanoparticles

Pulmotoxicological effects caused by long-term titanium dioxide nanoparticles exposure in mice

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