Molecular Mechanism of Mg-ATPase Activity

Nozadze, Eka; Arutinova, Nana; Tsakadze, Leila; Shioshvili, Lia; Leladze, Marina; Dzneladze, Sopio; Chkadua, Gvantsa

doi:10.1007/s00232-014-9769-2

Cited by 11 publications

(2 citation statements)

References 9 publications

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“…Ca 2+ acts as the second-messenger in signals transmission, while transport and distribution disorders of Ca 2+ might cause structural damage of cellular membranes and metabolic dysregulation ( Muchhal et al, 1997 ; Li et al, 2017 ; Pan et al, 2017 ). In addition, Mg 2+ acts as a cofactor in respiratory and energy metabolisms in fruit cells, and its disorder will conduce to peroxidation and oxidative stress ( Tewari et al, 2006 ; Nozadze et al, 2015 ). Besides, balanced Ca 2+ and Mg 2+ distribution and transport are beneficial for keeping cellular osmotic pressure, which contributes to cell structural integrity ( Wang et al, 2008 ; Li et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Phomopsis longanae Chi-Induced Disease Development and Pericarp Browning of Harvested Longan Fruit in Association With Energy Metabolism

et al. 2018

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Longan fruit is a popular subtropical fruit with a relatively short shelf life at room temperature mainly due to pericarp browning and fungal infection. This study aimed to investigate the infection of Phomopsis longanae Chi in longan fruit and its effects on the storability and shelf life of longan fruit. The relationship between the energy metabolism of harvested longan fruit and disease development and pericarp browning was elucidated. Results show that P. longanae-inoculation accelerated the deterioration of longan fruit and caused pericarp browning. It also led to the energy deficit in pericarp of longan fruit, which was reflected as lower contents of ATP and ADP, higher AMP content, and lower energy charge as compared to the control samples. Additionally, P. longanae-infection reduced the activities of H+-ATPase, Ca2+-ATPase, and Mg2+-ATPase in plasma, vacuolar, and mitochondrial membranes during the storage period. The results demonstrate that P. longanae-infection led to disease development and pericarp browning in harvested longan fruit, which were due to the infection-induced energy deficit and low ATPase activity that caused disorders of ion transport and distribution, and damaged the structure and function of vacuole, mitochondria, and eventually the whole cells of fruit tissues.

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Section: Discussionmentioning

confidence: 99%

Phomopsis longanae Chi-Induced Disease Development and Pericarp Browning of Harvested Longan Fruit in Association With Energy Metabolism

et al. 2018

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“…For this enzyme there is the mitochondrial isoform (mitCK), which uses ATP to form phosphocreatine and ADP, and the cytosolic isoform (cytCK) that forms creatine through phosphocreatine, generating ATP (Ferreira, 2014;Rech et al 2006Rech et al , 2018. Mg 2+ -ATPase is localized in the plasma membrane of renal and hepatic cells and is essential because it carries the Mg 2+ that is the cofactor of several enzymes involved in energy metabolism (Nozadze et al 2015). PK, CK and Mg 2+ -ATPase are important enzymes for the formation of energy.…”

Section: Introductionmentioning

confidence: 99%

Nanocapsules With Naringin And Naringenin Affect Hepatic and Renal Energy Metabolism Without Altering Serum Markers of Toxicity in Rats

Friedrich

Santos

Pohl

et al. 2020

Int J Innov Educ Res

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Naringin and naringenin are flavonoids found in citrus fruits and have several health benefits, however these compounds are susceptible to degradation, limiting their therapeutic application. To solve this problem, an alternative is to incorporate them into nanocapsules. The aim of this work was to evaluate the toxicity of these nanocapsules against renal and hepatic serum markers and also on the activities of pyruvate kinase, Mg2+-ATPase, and creatine kinase. Nanocapsules containing naringin and naringenin, nanocapsules without the active compounds and the compounds in their free form were administered orally, once a day, for 28 days. After treatment, the serum levels of hepatic and renal markers were not altered, nor the activities of pyruvate kinase tissue, however, the treatment of nanocapsules with flavonoids increased the activities of mitochondrial creatine kinase in the kidney and hepatic Mg2+-ATPase. Thus, renal and hepatic serum markers, which are normally used as indicators of toxicity, did not change after the period of administration of the nanoparticles. However, the activities of important enzymes of the energy metabolism in these organs were affected. Our findings reinforce that nanomaterial testing for toxicity needs to go beyond traditional methods to ensure the safe use of nanoparticles for therapeutic purposes.

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Contamination gradient affects differently carbonic anhydrase activity of mollusks depending on their feeding habits

et al. 2021

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Molecular Mechanism of Mg-ATPase Activity

Cited by 11 publications

References 9 publications

Phomopsis longanae Chi-Induced Disease Development and Pericarp Browning of Harvested Longan Fruit in Association With Energy Metabolism

Phomopsis longanae Chi-Induced Disease Development and Pericarp Browning of Harvested Longan Fruit in Association With Energy Metabolism

Nanocapsules With Naringin And Naringenin Affect Hepatic and Renal Energy Metabolism Without Altering Serum Markers of Toxicity in Rats

Contamination gradient affects differently carbonic anhydrase activity of mollusks depending on their feeding habits

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