Molecular mechanisms involved in physical exercise and factors that may influence them. particularities in patients with type 2 diabetes mellitus

I, Popa; Protasiewicz, Diana Cristina; Muntean, Cristina; Popa, Simona; Mota, Maria Carliana

doi:10.2478/v10255-012-0023-3

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Activation Of Energy Transformation Processes1

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2023

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“…Starting with EPI binding to cellular receptors and glycogen phosphorolysis, the signal is believed to be amplified 10 9 times. Phosphorolysis of glycogen provides higher levels of glucose-6-phosphate (G6P), an important intermediate in the glycolysis pathway (Popa et al, 2013). However, catabolic pathways at the G6P level are branched in a tissue/organ-specific manner.…”

Section: Activation Of Energy Transformation Processesmentioning

confidence: 99%

Potential oxidative stress related targets of mitochondria-focused therapy of PTSD

Kmita,

Pinna,

Lushchak

2023

Front. Physiol.

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Post-traumatic stress disorder (PTSD) remains a highly prevalent, under-diagnosed, and under-treated psychiatric disorder that often deteriorates over time, and is highly comorbid with major depressive disorder, suicidality, and substance use disorder. Several biomarkers have been proposed but have yet to be implemented into clinical practice. Treatments, including selective serotonin reuptake inhibitors, are efficacious in only a small number of patients, which underscores the need to develop novel, efficient treatments. Mitochondrial dysfunction resulting from chronic oxidative stress has been linked with both altered neurotransmitter signaling and the inflammatory response. Hereinafter, we discuss mechanisms by which mitochondrial dysfunction may contribute to the development of PTSD symptoms, and how these may even increase PTSD susceptibility. We also highlight possible therapeutic targets to reduce oxidative stress to prevent or treat PTSD symptoms.

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Section: Activation Of Energy Transformation Processesmentioning

confidence: 99%

Potential oxidative stress related targets of mitochondria-focused therapy of PTSD

Kmita,

Pinna,

Lushchak

2023

Front. Physiol.

View full text Add to dashboard Cite

show abstract

Molecular mechanisms involved in physical exercise and factors that may influence them. particularities in patients with type 2 diabetes mellitus

Abstract: Phisical activity, regularly performed, give us a lot of health benefit, especially in

Cited by 1 publication

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Potential oxidative stress related targets of mitochondria-focused therapy of PTSD

Potential oxidative stress related targets of mitochondria-focused therapy of PTSD

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