Potential oxidative stress related targets of mitochondria-focused therapy of PTSD

Abstract

Post-traumatic stress disorder (PTSD) remains a highly prevalent, under-diagnosed, and under-treated psychiatric disorder that often deteriorates over time, and is highly comorbid with major depressive disorder, suicidality, and substance use disorder. Several biomarkers have been proposed but have yet to be implemented into clinical practice. Treatments, including selective serotonin reuptake inhibitors, are efficacious in only a small number of patients, which underscores the need to develop novel, efficient treatments. Mitochondrial dysfunction resulting from chronic oxidative stress has been linked with both altered neurotransmitter signaling and the inflammatory response. Hereinafter, we discuss mechanisms by which mitochondrial dysfunction may contribute to the development of PTSD symptoms, and how these may even increase PTSD susceptibility. We also highlight possible therapeutic targets to reduce oxidative stress to prevent or treat PTSD symptoms.

Activation of GPER1 by G1 prevents PTSD‐like behaviors in mice: Illustrating the mechanisms from BDNF/TrkB to mitochondria and synaptic connection

“…Moreover, recent studies have found that impaired mitochondrial function is also a key factor in the development of PTSD, as well as an association between impaired mitochondrial function and chronic stress response and emotional instability. 48,49 We found that the repair of mitochondrial function was effective in ameliorating the abnormalities of fear memory, and PGC1α was a key target in this process. 27 PGC1α is a key mediator of mitochondrial energy metabolism and plays a role in regulating mitochondrial function.…”

The war continues not only on the front: a broader look at PTSD in the context of the Russian invasion and its impact on Ukrainian citizens – systematic rewiev

“…Preparations such as sertraline, paroxetine, fluoxetine are effective. 15,16 Vortioxetine, also an SSRI, may also be a promising option, especially because of its positive effects on attention and memory. 16 To sum up, we have many therapeutic options in the context of PTSD treatment, but it is a complex, long-lasting treatment that requires enormous commitment on the part of the patient, especially when it comes to psychotherapy.…”