Molecular mechanisms of apoptosis and autophagy elicited by combined treatment with oridonin and cetuximab in laryngeal squamous cell carcinoma

Cao, Shijie; Huang, Yiyuan; Zhang, Qiang; Lu, Fangjin; Donkor, Paul Owusu; Zhu, Yan; Qiu, Feng; Kang, Ning

doi:10.1007/s10495-018-1497-0

Cited by 25 publications

(16 citation statements)

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“…It induces autophagy to mediate apoptosis in human NSCLC A549 and neuroblastoma SHSY-5Y cells [558,568]. On the other hand, autophagy provides a protective role against oridonin-induced apoptosis, as autophagy inhibitor enhances oridonin-induced apoptosis in human cervical carcinoma HeLa, multiple myeloma RPMI 8266, laryngeal cancer HEp-2 and Tu212, and epidermoid carcinoma A-431 cells [569][570][571][572]. The anti-cancer effects of oridonin are also shown to be through suppressing angiogenesis and metastasis, which are the primary causes of tumor growth and metastasis.…”

Section: Oridoninmentioning

confidence: 99%

“…The combination of γ-tocotrienol and oridonin exerts synergistic anti-cancer effects in murine + SA mammary adenocarcinoma epithelial cells, which are mainly through the induction of autophagy [589]. Moreover, oridonin can enhance the pro-apoptotic activity of NVP-BEZ235 in human neuroblastoma SHSY-5Y and SK-N-MC cells through autophagy [558], whilst the combination of oridonin and cetuximab exhibits potent pro-apoptotic effect in human laryngeal cancer HEp-2 and Tu212 cells [572].…”

Section: Oridoninmentioning

confidence: 99%

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Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Oridoninmentioning

confidence: 99%

Section: Oridoninmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…13 Notably, it is confirmed that ATGs may be as a promising novel therapeutic target to enhance chemosensitivity. [14][15][16] There is evidence that PI3K/ Akt signaling pathway participates in the modulation of intracellular autophagy. [17][18][19] Inhibition of PI3K/Akt signaling transduction by regulating autophagy facilitates the enhancement of the radiosensitivity of prostate cancer, glioma, and so forth.…”

Section: Introductionmentioning

confidence: 99%

Effect of combination of curcumin and GLUT‐1 AS‐ODN on radiosensitivity of laryngeal carcinoma through regulating autophagy

Dai

Zhou

et al. 2020

Head & Neck

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Background This study is to explore the role of curcumin and GLUT‐1 antisense oligodeoxynucleotides (AS‐ODN) on autophagy modulation‐initiated radiosensitivity. Methods BALB/c mice were employed to establish xenograft model using Tu212 cell. The expression of autophagy‐ and apoptosis‐related proteins was determined by WB. Autophagosome was observed under transmission electron microscope. Apoptosis of tumor tissue were detected by TUNEL staining. Results Combinations of curcumin and GLUT‐1 AS‐ODN with 10 Gy inhibited the tumor growth by inducing apoptosis of laryngeal cancer cells followed with the enhancement of autophagy. 3‐MA also had a promotion effect on irradiation‐mediated growth inhibition possibly by depressing PI3K and on curcumin/GLUT‐1 AS‐ODN‐mediated growth inhibition potentially by regulating autophagic events. Of note, a de‐escalation of radiotherapy dose (5 Gy) along with curcumin, GLUT‐1 AS‐ODN or 3‐MA produced a stronger effect than high dosage of radiotherapy (10 Gy) alone. Conclusions Curcumin and GLUT‐1 AS‐ODN improve the radiosensitivity of laryngeal carcinoma through regulating autophagy and inducing apoptosis.

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“…Cetuximab and oridonin are reported to synergize in induction of cell death. It is now shown that the combination treatment not only induces apoptosis but also autophagy in laryngeal squamous cell carcinoma, suggesting clinical application [10]. IL6/GP130 inhibitors were found to increase the activity of 5-fluorouracil in colon cancer, suggesting a promising strategy for future therapy [11].…”

Section: The Editors' Choicementioning

confidence: 99%

Programmed death, cells on the last train to glory

Nowak-Śliwińska

2020

Apoptosis

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Cell death and the mechanisms of it are an increasing interest of researchers worldwide. This is best reflected by the number of scientific articles on cell death over the last 3 years (2017-2019), which increased by 64% as compared to the 3 years before (2014-2016) from 57,000 to 93,500 articles. Reports on apoptosis, necroptosis and ferroptosis are in the lead of these numbers. It is clear that this interest in programmed cell death is based on the fact that knowledge on this subject provides insight in biology in general, as well as in the processes of disease and resulting opportunities for therapeutic intervention.

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Molecular mechanisms of apoptosis and autophagy elicited by combined treatment with oridonin and cetuximab in laryngeal squamous cell carcinoma

Cited by 25 publications

References 50 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Effect of combination of curcumin and GLUT‐1 AS‐ODN on radiosensitivity of laryngeal carcinoma through regulating autophagy

Programmed death, cells on the last train to glory

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