Molecular mechanisms of control of differentiation of regulatory t-lymphocytes by exogenous melatonin

Glebezdina, N. S.; Олина, А. А.; Nekrasova, I. V.; Куклина, Е. М.

doi:10.31857/s0869-56524842224-227

Cited by 2 publications

(2 citation statements)

References 12 publications

(15 reference statements)

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“…Gut-derived Treg cells have been confirmed to feature in the prognosis of stroke, and studies have confirmed that programmed death protein 1 (PD-1) and CC-chemokine ligand 28 (CCL28) regulate Treg cells (Wang P. et al, 2019;He et al, 2021). In addition, melatonin also has a regulatory effect on Treg cells (Álvarez-Sánchez et al, 2015;Glebezdina et al, 2019). Therefore, the combined effect of melatonin and gut microbiota whether further affect the prognosis of SCI through Treg cells is worthy of in-depth study.…”

Section: Discussionmentioning

confidence: 99%

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Zhang

Lang²,

Guo³

et al. 2022

Front. Neurosci.

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Spinal cord injury (SCI) is a central nervous system (CNS) disease that can cause sensory and motor impairment below the level of injury. Currently, the treatment scheme for SCI mainly focuses on secondary injury and complications. Recent studies have shown that SCI leads to an imbalance of intestinal microbiota and the imbalance is also associated with complications after SCI, possibly through the microbial-brain-gut axis. Melatonin is secreted in many parts of the body including pineal gland and gut, effectively protecting the spinal cord from secondary damage. The secretion of melatonin is affected by circadian rhythms, known as the dark light cycle, and SCI would also cause dysregulation of melatonin secretion. In addition, melatonin is closely related to the intestinal microbiota, which protects the barrier function of the gut through its antioxidant and anti-inflammatory effects, and increases the abundance of intestinal microbiota by influencing the metabolism of the intestinal microbiota. Furthermore, the intestinal microbiota can influence melatonin formation by regulating tryptophan and serotonin metabolism. This paper summarizes and reviews the knowledge on the relationship among intestinal microbiota, melatonin, and SCI in recent years, to provide new theories and ideas for clinical research related to SCI treatment.

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Section: Discussionmentioning

confidence: 99%

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Zhang

Lang²,

Guo³

et al. 2022

Front. Neurosci.

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“…to reduce the rate of insulin secretion after receptor activation [60]. MT receptors have also been identified in leukocytes [61][62][63] and melatonin is suggested to modulate (or regulate) the immune system by (for example) stimulating lymphocytes via these receptors, predominantly via the MT2 receptor [64]. Complete removal of the pineal gland causes partial deterioration in the immune responses of rats [65,66], and administration of melatonin in pinealectomized animals reverses the negative effect on immune responses [66].…”

Section: Discussionmentioning

confidence: 99%

The Melatonin Receptor MT2 Is Partly Involved in the Anti-Inflammatory Effects of Melatonin in Rats With Type 2 Diabetes Mellitus

Yapışlar

Hacıosmanoğlu

Sarioğlu

et al. 2021

Preprint

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Background: Insulin resistance is associated with a pro-inflammatory state increasing the risk for complications in patients with type 2 diabetes mellitus (T2DM). In addition to its chronobiotic effects, the pineal hormone melatonin is also known to exert anti-inflammatory and antioxidant effects. Furthermore, melatonin was also suggested to affect insulin secretion and melatonin levels were reported to be decreased in T2DM patients Aims: The aim of this study was therefore to investigate the effect of melatonin on inflammation in diabetic rats and to study the possible involvement of the melatonin receptor, MT2. Materials and Methods: Male Sprague Dawley rats were randomly divided into four experimental groups (n = 10 per group):1) control, 2) streptozotocin/nicotinamid induced diabetes type 2 (T2DM), 3) T2DM treated with melatonin (500 µg/kg/day), and 4) T2DM treated with melatonin (500 µg/kg/day) and the selective MT2 receptor antagonist luzindole (0.25 g/kg/day). Blood samples were taken for biochemical parameters and various tissue samples (liver, adipose tissue, brain) were removed for immunohistochemistry (IHC), western blot (WB) and Q-PCR analyses, respectively. Results: Melatonin significantly reduced increased blood levels of liver transaminases (AST, ALT) and blood urea nitrogen (BUN) in diabetic rats. Furthermore, in liver and adipose tissue of treated rats, melatonin administration resulted in considerable lower expression of the increased inflammatory markers IL-1β, IL-6, TNF-α and NF-κB, as shown by reduction in RNA and protein levels. The MT2 receptor was only partly involved in the anti-inflammatory effects of melatonin. Conclusions: Our results suggest that melatonin has relevant anti-inflammatory effects in diabetic rats. Further studies in humans could prove the potential clinical benefit of melatonin supplementation in patients with T2DM.

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Molecular mechanisms of control of differentiation of regulatory t-lymphocytes by exogenous melatonin

Cited by 2 publications

References 12 publications

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

The Melatonin Receptor MT2 Is Partly Involved in the Anti-Inflammatory Effects of Melatonin in Rats With Type 2 Diabetes Mellitus

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