Molecular mechanisms of pidolate magnesium action and its neurotropic affects

Громова, О. А.; Torshin, I. Yu.; Калачева, А. Г.; Федотова, Л. Э.; Рудаков, К. В.

doi:10.17116/jnevro201611612196-103

Cited by 7 publications

(2 citation statements)

References 55 publications

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“…The possibility of using this magnesium compound in children over one year old, its convenient form as a solution and a caramel flavor determine its application in combination with vitamin B6 in young children as a drug of choice for magnesium deficiency. As magnesium pidolate is the only sugar-free form of organic magnesium, it can be recommended for diabetic and obese patients (Gromova et al 2016a).…”

Section: Resultsmentioning

confidence: 99%

“…Magnesium lactate therapy in combination with vitamin B6 is advisable with spastic contractions of the uterus, the gastrointestinal tract and limb muscles caused by magnesium deficiency, and is applied in obstetrics and gynecology, gastroenterology and neurology (Gröber et al 2015;Gromova et al 2016a;Globa 2019). The inclusion of this magnesium compound in the therapy of patients with osteoarthritis made it possible to slow down the bone tissue remodeling and reduce the joint syndrome symptoms (Kolomiyets and Mailian 2016).…”

Section: Resultsmentioning

confidence: 99%

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Possible prospects for using modern magnesium preparations for increasing stress resistance during COVID-19 pandemic

Sankova

Kytko

Meylanova

et al. 2020

RRP

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Introduction: The relevance of the issue of increasing stress resistance is due to a significant deterioration in the mental health of the population caused by the special conditions of the disease control and prevention during the COVID-19 pandemic. Recently, the decisive role in the severity of clinico-physiological manifestations of maladjustment to stress is assigned to magnesium ions. The aim of the work was to study the magnesium importance in the body coping mechanisms under stress for the pathogenetic substantiation of the magnesium correction in an unfavorable situation of disease control and prevention during the COVID-19 pandemic. Materials and methods: The theoretical basis of this scientific and analytical review was an analysis of modern Russian and foreign literature data posted on the electronic portals MEDLINE, PubMed-NCBI, Scientific Electronic Library eLIBRARY.RU, Google Academy, and CyberLeninka. Results and discussion: It was shown that the total magnesium level in the body plays the indicator role of the body functional reserves. Acute and chronic stresses significantly increase the magnesium consumption and cause a decrease in its body content. Magnesium deficiency is one of the main pathogenetic mechanisms of reducing stress resistance and adaptive body reserves. Arising during the COVID-19 pandemic, increased nervous and emotional tension, the lack of emotional comfort and balance can lead to the onset or deterioration of magnesium deficiency, which manifests itself in mental burnout and depletion of adaptive capacities. The inability to synthesize magnesium in the body necessitates including foodstuffs high in magnesium in the population diet during this period. The appointment of magnesium preparations is pathogenetically justified with moderate and severe magnesium deficiency. This therapy should take into account the major concomitant diseases, severity of magnesium deficiency, and a patient’s age. Conclusion: magnesium correction, carried out during the COVID-19 pandemic, will contribute to increasing stress resistance, preventing mental diseases and improving the population’s life quality.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%