Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances

Soderlund, David M.

doi:10.1007/s00204-011-0726-x

Cited by 485 publications

(351 citation statements)

References 84 publications

Supporting

Mentioning

328

Contrasting

Unclassified

Order By: Relevance

“…Exposure to pyrethroid insecticides can induce neurobehavioral effects in rodents and other species, including humans 7,8,9,10 . Aspects of open field behavior and catalepsy 11,12 , conditioned behavior 12,13,14 , motor activity 15,16 , anxiety 11,17 and aggressive behavior 11 .…”

Section: Deltamethrin (Dtm [(S)-a-cyano-d-phenoxyben-mentioning

confidence: 99%

See 1 more Smart Citation

Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos

Ricci

Ferreira

Habr

et al. 2013

Braz. J. Vet. Res. Anim. Sci.

View full text Add to dashboard Cite

Pyrethroid insecticides are extensively used for pest control around the house, flea prevention for pets, and plant sprays for the home and in agriculture. Deltamethrin (DTM) is a Type II pyrethroid insecticide used to control a variety of insects in agriculture and domestic environments. The present study investigated the possible anxiogenic effects of DTM (1, 3, and 10 mg/kg) in rats using behavioral and neurochemical methods. We assessed general locomotor activity and behavior in the elevated plus maze and open field test. Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) increased striatal serotonin neurotransmitter and its metabolite, and (vii) did not alter motor coordination on the rotarod, grooming duration in the open field test, rectal temperature, or hippocampal neurotransmitter levels. These data suggest that DTM at the present doses and under these experimental conditions presented a similar profile to that of anxiogenic drugs, unrelated with the increased serotonin neurotransmission.Keywords: Deltamethrin. Pyrethroid. Anxiety. Behavior. Central neurotransmitters. ResumoInseticidas piretróides são amplamente utilizados para controle de pragas, como na prevenção de pulgas em animais de estimação e sprays de plantas para a casa e na agricultura. Deltametrina (DTM) é um inseticida piretróide tipo II usado para controlar uma variedade de insetos na agricultura e ambientes domésticos. O presente estudo investigou os possíveis efeitos ansiogênicos de DTM (1, 3 e 10 mg/kg) em ratos, utilizando métodos comportamentais e neuroquímicos. Foi avaliada a atividade locomotora geral e comportamento no labirinto em cruz elevado e teste de campo aberto. Os níveis de neurotransmissores e metabólitos no estriado e hipocampo também foram mensurados. DTM (i) reduziu a locomoção e a frequência de levantar, (ii) aumentou da duração da imobilidade, (iii) reduziu o tempo de interacção social, (iv) reduziu a percentagem de entradas e tempo gasto nos braços abertos do elevado labirinto em cruz, (v) reduziu o número de cruzamentos no centro do labirinto em cruz elevado, (vi) aumentou neurotransmissor serotonina e de seu metabólito estriatal, e (vii) não alterou a coordenação motora no rotarod, duração do grooming no teste de campo aberto, temperatu...

show abstract

Section: Deltamethrin (Dtm [(S)-a-cyano-d-phenoxyben-mentioning

confidence: 99%

“…Type II pyrethroids may act on g-aminobutyric acid (GABA) receptors as benzodiazepine antagonists 8,19,20 .…”

Section: Deltamethrin (Dtm [(S)-a-cyano-d-phenoxyben-mentioning

confidence: 99%

Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos

Ricci

Ferreira

Habr

et al. 2013

Braz. J. Vet. Res. Anim. Sci.

View full text Add to dashboard Cite

show abstract

“…Although most pyrethroids are relatively nontoxic to humans and other mammals, high doses of some congeners can be acutely neurotoxic. Clinical signs are primarily attributed to the binding of the parent (unmetabolized) compound to voltage-gated sodium channels in axonal membranes (19). Thus, an important study objective was to learn whether levels of unbound DLM are elevated during immaturity and for how long this condition persists.…”

mentioning

confidence: 99%

Ontogeny of plasma proteins, albumin and binding of diazepam, cyclosporine, and deltamethrin

et al. 2015

View full text Add to dashboard Cite

“…By binding to specific sodium channel proteins, pyrethroids slow down the closing and opening of these channels, which causes the nervous system to become hyper-excited due to the increased amount of sodium entering the channels [18,20,21]. Gamma aminobutyric acid (GABA)-gated chloride channels and calcium channels have been implicated as additional sites of action [22]. The classification of pyrethroids is based on chemistry and two different syndromes: T (tremors) and CS (choreoathetosis/ salivation).…”

Section: Discussionmentioning

confidence: 99%