Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids

Hossain, Mohammed Kawser; Dayem, Ahmed Abdal; Han, Jihae; Yin, Yingfu; Kim, Kyeongseok; Saha, Subbroto Kumar; Yang, Gwang-Mo; Choi, Hye Yeon; Cho, Ssang-Goo

doi:10.3390/ijms17040569

Cited by 371 publications

(241 citation statements)

References 211 publications

(256 reference statements)

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“…It is also well known that COJ contains a high concentration of anthocyanins particularly cyanidin-3-glucoside, which seems to be implicated in the reduction of body weight and fat accumulation. The effect of COJ consumption on weight gain is controversial, especially because of its sugar content [31, 32]. In this study, COJ consumption resulted in augmented carbohydrates intakes with respect to baseline and one month later on free diet (follow-up).…”

Section: Discussionmentioning

confidence: 88%

Effect of Red Orange Juice Consumption on Body Composition and Nutritional Status in Overweight/Obese Female: A Pilot Study

Azzini

Venneria

Ciarapica

et al. 2017

Oxidative Medicine and Cellular Longevity

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The main objective of this research was to determine whether a commercial orange juice rich in anthocyanins could have an effect on body weight and on clinical parameters related to obesity including antioxidant status, lipid profile, and metabolic and inflammatory biomarkers. 11 women with an average BMI of 34.4 ± 4.8 kg/m2 were enrolled in a pilot study. Over a period of 12 weeks they received 500 mL daily dose into two doses (250 mL) of commercial red orange juice (COJ). The biochemical parameters were measured at baseline and at the end of the study (12 weeks). One month later upon free diet, a follow-up was performed measuring the same variables. The daily consumption of 500 mL of COJ had no significant effects on body weight, while there was a decrease in total cholesterol and LDL cholesterol. The grade of obesity implies different changes in inflammation biomarkers. In obese women, our data do not seem to support evidence that commercial red orange juice consumption acts as functional food preventing obesity and metabolic disorders such as insulin resistance and/or inflammatory status.

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Section: Discussionmentioning

confidence: 88%

Effect of Red Orange Juice Consumption on Body Composition and Nutritional Status in Overweight/Obese Female: A Pilot Study

Azzini

Venneria

Ciarapica

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Phytochemical analysis show these foods to be rich sources of flavonoids (Shafaghat, 2010). Previous studies (Galleano et al, 2012;Hossain et al, 2016;Hurt & Wilson, 2012) continue to support flavonoid-rich foods and their protective mechanisms for preventing and reducing obesity and obesity-related diseases. Evidence regarding the dietary potential found in dates (Phoenix dactylifera), grapes (Vitis vinifera), olives and olive oil (Olea europaea), pomegranates (Punica granatum), and whole grains have been well established in the literature (Al-Muammar & Khan, 2012;Cho, Qi, Fahey Jr, & Klurfeld, 2013;Chuang & McIntosh, 2011;Mallhi et al, 2014;Pérez-Martínez, García-Ríos, Delgado-Lista, Pérez-Jiménez, & López-Miranda, 2011).…”

Section: Discussionmentioning

confidence: 93%

‘The Quranic Garden’: Consumption of Fruits, Vegetables, and Whole Grains from an Islamic Perspective

Aboul‐Enein¹

2017

IJMMU

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The increasing global prevalence of obesity and obesity-related co-morbidities has prompted calls for culturally-congruent dietary patterns and health-promoting strategies and interventions appropriate for specific populations and communities. The Holy Quran is viewed as the primary behavioral and religious guidance for all Muslims around the world. Diets rich in plant-based foods and its protective role in the reduction and prevention of obesity-related diseases have been established. The purpose of this study is to examine passages cited in the Holy Quran with particular reference given to plant foods cited and features of a plant-based diet. A narrative review of the Holy Quran in two formats was conducted to identify plant-based foods. A total of 36 passages were identified in this review with a considerable focus on the consumption of dates, olives, grapes, whole grains, pomegranates, and other plant-based foods. This review supports the Holy Quran as an authoritative culturally-relevant faith-based resource for dietitians, public health educators, and other health professionals operating in Muslim populations and communities around the world to promote dietary patterns rich in fruits, vegetables, and whole grains.

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“…Overall, flavonoids continue to be extensively studied due to their potential treatment benefits in disorders such as obesity, diabetes, and cardiovascular disease, as well as cancer. 8,9 …”

Section: Introductionmentioning

confidence: 99%

Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6

2017

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Monocarboxylate transporter 6 (MCT6; SLC16A5) has been recognized for its role as a xenobiotic transporter, with characterized substrates probenecid, bumetanide, and nateglinide. To date, the impact of commonly ingested dietary compounds on MCT6 function has not been investigated, and therefore, the objective of this study was to evaluate a variety of flavonoids for their potential MCT6-specific interactions. Flavonoids are a large group of polyphenolic phytochemicals found in commonly consumed plant-based products that have been recognized for their dietary health benefits. The uptake of bumetanide in human MCT6 gene-transfected Xenopus laevis oocytes was significantly decreased in the presence of a variety of flavonoids (e.g., quercetin, luteolin, phloretin, and morin), but was not significantly affected by flavonoid glycosides (e.g., naringin, rutin, phlorizin). The IC50 values of quercetin, phloretin, and morin were determined to be 25.3 ± 3.36, 17.3 ± 2.37, and 33.1 ± 3.29 μM, respectively. The mechanism of inhibition of phloretin was reversible and competitive, with a Ki value of 22.8 μM. Furthermore, typical MCT substrates were also investigated for their potential interactions with MCT6. Substrates of MCTs 1, 2, 4, 8, and 10 did not cause any significant decrease in MCT6-mediated bumetanide uptake, suggesting that MCT6 has distinct compound selectivity. In summary, these results suggest that dietary aglycon flavonoids may significantly alter the pharmacokinetics and pharmacodynamics of bumetanide and other MCT6-specific substrates, and may represent potential substrates for MCT6.

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Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids

Cited by 371 publications

References 211 publications

Effect of Red Orange Juice Consumption on Body Composition and Nutritional Status in Overweight/Obese Female: A Pilot Study

Effect of Red Orange Juice Consumption on Body Composition and Nutritional Status in Overweight/Obese Female: A Pilot Study

‘The Quranic Garden’: Consumption of Fruits, Vegetables, and Whole Grains from an Islamic Perspective

Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6

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