2021
DOI: 10.1016/j.placenta.2021.02.005
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Molecular mechanisms regulating lysophosphatidylcholine acyltransferase 1 (LPCAT1) in human pregnancy

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Cited by 10 publications
(4 citation statements)
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“…Lysophosphatidylcholine acyltransferase (LPCAT) catalyzes the conversion of LPC to PC in the presence of Acyl-CoA. , Steroids promote the expression of LPCAT and LPCAT levels, which rapidly increase in a time-dependent manner over a 48-hour period . The expressions of LPCAT were determined in cells harboring and knocking out MNRR1 in the presence or absence of steroids . The results showed that the level of LPCAT downregulated in MNRR1-knockout cells with steroid treatment.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Lysophosphatidylcholine acyltransferase (LPCAT) catalyzes the conversion of LPC to PC in the presence of Acyl-CoA. , Steroids promote the expression of LPCAT and LPCAT levels, which rapidly increase in a time-dependent manner over a 48-hour period . The expressions of LPCAT were determined in cells harboring and knocking out MNRR1 in the presence or absence of steroids . The results showed that the level of LPCAT downregulated in MNRR1-knockout cells with steroid treatment.…”
Section: Resultsmentioning
confidence: 99%
“…49 The expressions of LPCAT were determined in cells harboring and knocking out MNRR1 in the presence or absence of steroids. 50 The results showed that the level of LPCAT downregulated in MNRR1knockout cells with steroid treatment. As shown in Figure 4D, the concentration of LPC increased significantly, with 3.39 mg kg −1 in raw samples, 3.73 mg kg −1 in 8 h samples, 4.59 mg kg −1 in 10 h samples, and 5.16 mg kg −1 in 12 h samples.…”
Section: Cortisol Perturbed Proteins and Lipids In Glycerophospholipi...mentioning
confidence: 95%
“…Purandare et al. revealed that LPCAT protein was expressed from the initiation of embryogenesis and regulated by oxygen tension, several mitochondrial regulators, and antenatal corticosteroids ( 31 ). The role of LPCAT in regulating surfactant phospholipids and respiratory function was also verified in a mouse model ( 32 ).…”
Section: Discussionmentioning
confidence: 99%
“…Since the pro-inflammatory signaling proceeds through degradation of mitochondrial MNRR1 whereas its nuclear function is sufficient to rescue the effects of LPS, transcriptional activation of MNRR1 can provide a treatment option. In addition, the recent demonstration that MNRR1 activation may be able to augment or in some cases even replace steroids for respiratory distress syndrome [109] adds additional impetus for development of this targeted therapy.…”
Section: Discussionmentioning
confidence: 99%