1999
DOI: 10.1016/s0928-8244(99)00144-3
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Molecular mimetics of polysaccharide epitopes as vaccine candidates for prevention of Neisseria meningitidis serogroup B disease

Abstract: Neisseria meningitidis is a major cause of meningitis and sepsis. Despite nearly 25 years of work, there is no promising vaccine candidate for prevention of disease caused by meningococcal B strains. This review summarizes newer approaches for eliciting protective meningococcal B immune responses, including the use of molecular mimetics of group B polysaccharide and conserved membrane proteins as immunogens. The capsular polysaccharide of this organism is conserved and serum antibody to this capsule confers pr… Show more

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Cited by 28 publications
(36 citation statements)
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“…Moreover, previously identified peptides lacked immunogenic properties (9,23). This is not surprising, because only a minority of selected peptide mimotopes have the ability to induce an immune response, as shown by an early report (16).…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…Moreover, previously identified peptides lacked immunogenic properties (9,23). This is not surprising, because only a minority of selected peptide mimotopes have the ability to induce an immune response, as shown by an early report (16).…”
Section: Discussionmentioning
confidence: 96%
“…Using this technique, peptides capable of competing with the nominal Ag for Ab binding can be isolated with relative ease. Quite often, however, these mimics are not immunogenic (16,23). We describe here the isolation of peptide mimics of the MenB CP capable of producing significant bactericidal responses after immunization.…”
mentioning
confidence: 99%
“…Although several other studies have identified cyclic peptide mimics from cystine-constrained phage display libraries (Brett et al, 2002;Moe et al, 1999;Tiwana et al, 2005), cyclic peptides are rarely identified from linear phage display libraries. There is one previous study that reported the identification of cyclic peptides with two cysteine residues from a linear phage display library (Coulon et al, 2004).…”
Section: Discussionmentioning
confidence: 99%
“…This lack of ability to induce a carbohydratereactive immune response is similar to what has been observed by others. Peptide mimics of Neisseria meningitidis group B capsular polysaccharide (CPS) that were identified from a mAb that does not cross-react with human tissue failed to elicit CPS cross-reactive antibodies (Lauvrak et al, 2004;Moe et al, 1999). Phalipon et al (1997) identified 19 peptide mimics of Shigella flexneri serotype 5a LPS but out of 19 that were tested only two were able to induce crossreactive anti-LPS antibody responses in mice.…”
Section: Discussionmentioning
confidence: 99%
“…Peptide mimotopes have been identiÂźed from libraries displaying random linear or structurally constrained peptides on the surface of coliphage by direct interaction with antibodies of the required carbohydrate speciÂźcity. These include mimotopes of bacterial carbohydrates [11±13] , capsular polysaccharides [14,15] and HIV envelope glycoproteins [16]. Furthermore, combinatorial solid-phase peptide libraries have provided an alternative peptide approach for the identiÂźcation of mimotopes [17].…”
Section: Mimotope Vaccinesmentioning
confidence: 99%