Molecular Modeling of the Anti-HIV Activity Mechanism of Iodine-Containing Drugs Armenicum and FS-1

Abstract

Drugs Armenicum and FS-1 are a solution of ionic nanostructured complexes of α-dextrin. In the active centers of these drugs, located inside the dextrin helix, molecular iodine has such an electronic form that minimizes toxic effects in the human body, so these drugs can be used for parenteral and oral administration. On the human lymphoblastoid cell line MT-2, the effect of the antiviral action of FS-1 against HIV-1 was established. Literature data on the results of treatment of people with HIV infection with Armenicum are presented. The mechanism of anti-HIV action of drugs Armenicum and FS-1 was proposed by the molecular modeling method. Using the DFT/B3PW91/6-31G** approach, it was shown that LiI(Cl)I 2 active center drugs of Armenicum and FS-1 can be segregated from the dextrin helix and can form a complex with the ACT nucleotide triplet, which is part of a specific fragment of viral DNA that binds to the active center of integrase. The formation of this complex is a key moment in the mechanism of anti-HIV drug action. Molecular iodine and lithium halide, which are part of the active complexes, inhibit the active center of the catalytic domain of the integrase. A new nucleoprotein complex is created that destroys the nucleoprotein preintegration complex (PIC) and inhibits the HIV DNA and the active center of the catalytic domain, while a new N−I bond appears in the viral DNA in the cytosine pyrimidine cycle.

Process for Producing Lithium Iodide Cleanly through Electrodialysis Metathesis

“…It is used to synthesize dopamine drugs and plays a role in treating Parkinson’s disease, relieving symptoms such as muscle stiffness and involuntary tremors . Additionally, lithium iodide is used to synthesize l -ribonucleoside, an anti-hepatitis B and HIV drug. , There are several methods for preparing lithium iodide, but most involve the use of hazardous chemicals. For example, the commonly used neutralization method involves using hydriodic acid as the raw material and adding lithium carbonate or lithium hydroxide to produce lithium iodide through a neutralization reaction.…”