2010
DOI: 10.1016/j.jmgm.2009.11.010
|View full text |Cite
|
Sign up to set email alerts
|

Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
8
0

Year Published

2010
2010
2016
2016

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 20 publications
(9 citation statements)
references
References 46 publications
1
8
0
Order By: Relevance
“…They can participate in many reactions [1][2][3][4] contribute extensively to the metabolism of xenobiotics and endogenous compounds, such as drugs, environmental pollutants, and carcinogens [5]. Especially, 1A2, 2 C19, 2 C9, 2D6, 2E1, and 3A4/5 contribute to the metabolism of about 90% drugs in current clinical use [6][7][8].…”
Section: Introductionmentioning
confidence: 99%
“…They can participate in many reactions [1][2][3][4] contribute extensively to the metabolism of xenobiotics and endogenous compounds, such as drugs, environmental pollutants, and carcinogens [5]. Especially, 1A2, 2 C19, 2 C9, 2D6, 2E1, and 3A4/5 contribute to the metabolism of about 90% drugs in current clinical use [6][7][8].…”
Section: Introductionmentioning
confidence: 99%
“…Ramachandran plot of the CYP4H31v2 model showed that 1.7% of the residues were located in the disallowed regions. This compared favorably with residues in the disallowed regions of models of Anopheles minimus CYP6AA3, CYP6P7 and CYP6P8 and human CYP4A22, which ranged from 0.5 to 2.9% (Gajendrarao et al, 2010;Lertkiatmongkol et al, 2011). The ProSA z-score indicated that the overall quality of the model was good and comparable to the z-score of experimentally determined proteins of similar size.…”
Section: Discussionmentioning
confidence: 67%
“…Those residues, which deviated more than 2.5 Å were considered as highly flexible elements of the protein. 31 As shown in Figure 4, the high fluctuations occurred in the loop regions and the low fluctuations occurred in the -helix and -sheet regions. The Figure S1, showed 99.7% of the residues in the favored or allowed regions and only 0.3% in disallowed region.…”
Section: Resultsmentioning
confidence: 86%