Molecular Probe Crossing Blood–Brain Barrier for Bimodal Imaging–Guided Photothermal/Photodynamic Therapies of Intracranial Glioblastoma

Li, Bo; Xiao, Hong; Cai, Mingyue; Li, Xiaoxia; Xu, Xiaolin; Wang, Shiyin; Huang, Si; Wang, Yong; Cheng, Du; Pang, Pengfei; Shan, Hong; Shuai, Xintao

doi:10.1002/adfm.201909117

Cited by 47 publications

(35 citation statements)

References 30 publications

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“…Copyright 2014, American Chemical Society. d Schematic illustration of the molecular probe (iRGD-ILD) crossing BBB via α v β 3 integrin-receptor-mediated transcytosis to enable bimodal MR/fluorescence imaging-guided photothermal/photodynamic therapy of intracranial glioblastoma (Reprint with permission [ 170 ]. Copyright 2020, Wiley–VCH) …”

Section: Nuclear Medical Imagingmentioning

confidence: 99%

“…Moreover, Shuai’s group reported a kind of carrier-free nanoprobe, wherein indocyanine green (ICG) was conjugated with cRGD and Gd-DTPA to conduct MR/FL imaging-guided phototherapy (Fig. 8 d) [ 170 ]. A two-photon confocal laser scanning microscope (CLSM) was used to directly observe the BBB penetration process of the nanoprobe.…”

Section: Nanomaterials For Multimodal Imaging Of Gliomamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Construction of nanomaterials as contrast agents or probes for glioma imaging

Zhao

Peng

et al. 2021

J Nanobiotechnol

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Malignant glioma remains incurable largely due to the aggressive and infiltrative nature, as well as the existence of blood–brain-barrier (BBB). Precise diagnosis of glioma, which aims to accurately delineate the tumor boundary for guiding surgical resection and provide reliable feedback of the therapeutic outcomes, is the critical step for successful treatment. Numerous imaging modalities have been developed for the efficient diagnosis of tumors from structural or functional aspects. However, the presence of BBB largely hampers the entrance of contrast agents (Cas) or probes into the brain, rendering the imaging performance highly compromised. The development of nanomaterials provides promising strategies for constructing nano-sized Cas or probes for accurate imaging of glioma owing to the BBB crossing ability and other unique advantages of nanomaterials, such as high loading capacity and stimuli-responsive properties. In this review, the recent progress of nanomaterials applied in single modal imaging modality and multimodal imaging for a comprehensive diagnosis is thoroughly summarized. Finally, the prospects and challenges are offered with the hope for its better development.

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Section: Nuclear Medical Imagingmentioning

confidence: 99%

Section: Nanomaterials For Multimodal Imaging Of Gliomamentioning

confidence: 99%

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Construction of nanomaterials as contrast agents or probes for glioma imaging

Zhao

Peng

et al. 2021

J Nanobiotechnol

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“…Although not fully explained in the original research, it is possible that the Reactive oxygen species (ROS), are oxygenated compounds having unpaired electrons. ROS are generated during cellular processes, or by the interaction of the ligand excited state and the molecular oxygen [222][223][224][225]. For example, hypochlorous acid (HClO), a ROS produced by living cells, plays an essential role in immune systems.…”

Section: Sensing Of Chemical Species Inside Biological Systems Using Visible Emitting Ln IIImentioning

confidence: 99%

Recent Advances in Luminescence Imaging of Biological Systems Using Lanthanide(III) Luminescent Complexes

Monteiro

2020

Molecules

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The use of luminescence in biological systems allows one to diagnose diseases and understand cellular processes. Molecular systems, particularly lanthanide(III) complexes, have emerged as an attractive system for application in cellular luminescence imaging due to their long emission lifetimes, high brightness, possibility of controlling the spectroscopic properties at the molecular level, and tailoring of the ligand structure that adds sensing and therapeutic capabilities. This review aims to provide a background in luminescence imaging and lanthanide spectroscopy and discuss selected examples from the recent literature on lanthanide(III) luminescent complexes in cellular luminescence imaging, published in the period 2016–2020. Finally, the challenges and future directions that are pointing for the development of compounds that are capable of executing multiple functions and the use of light in regions where tissues and cells have low absorption will be discussed.

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“…Photothermal therapy (PTT) as a non-invasive method for cancer therapy has aroused widespread attention over the last decade. [9][10][11][12][13][14] PTT destroys tumor cells by employing lightabsorbing agents to generate localized heat under continuous NIR irradiation. In view of the recognized advantages of PTT, such as minimal invasiveness, noninvasive penetration and low toxicity, PTT has been shown to be a promising strategy to treat cancer.…”

Section: Introductionmentioning

confidence: 99%