2022
DOI: 10.3389/fimmu.2022.911260
|View full text |Cite
|
Sign up to set email alerts
|

Molecular profile reveals immune-associated markers of medulloblastoma for different subtypes

Abstract: Medulloblastoma, a common pediatric malignant tumor, has been recognized to have four molecular subgroups [wingless (WNT), sonic hedgehog (SHH), group 3, group 4], which are defined by the characteristic gene transcriptomic and DNA methylomic profiles, and has distinct clinical features within each subgroup. The tumor immune microenvironment is integral in tumor initiation and progression and might be associated with therapeutic responses. However, to date, the immune infiltrative landscape of medulloblastoma … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
3
0

Year Published

2023
2023
2023
2023

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(3 citation statements)
references
References 50 publications
0
3
0
Order By: Relevance
“…Interestingly, high levels of GAB1 expression are associated with poor prognosis in patients with gliomas, hepatocellular carcinoma, and ovarian cancer [ 80 , 81 , 82 ]. It has been delineated that GAB1 is a biomarker of poor prognosis in meningiomas, medulloblastomas, and bone and soft tissue sarcomas [ 83 , 84 , 85 , 86 ].…”
Section: Role Of Gab1 In Cancermentioning
confidence: 99%
See 1 more Smart Citation

The Role of GAB1 in Cancer

Pérez-Baena,
Cordero-Pérez,
Pérez-Losada
et al. 2023
Cancers
“…Interestingly, high levels of GAB1 expression are associated with poor prognosis in patients with gliomas, hepatocellular carcinoma, and ovarian cancer [ 80 , 81 , 82 ]. It has been delineated that GAB1 is a biomarker of poor prognosis in meningiomas, medulloblastomas, and bone and soft tissue sarcomas [ 83 , 84 , 85 , 86 ].…”
Section: Role Of Gab1 In Cancermentioning
confidence: 99%
“…Interestingly, high levels of GAB1 expression are associated with poor prognosis in patients with gliomas, hepatocellular carcinoma, and ovarian cancer [80][81][82]. It has been delineated that GAB1 is a biomarker of poor prognosis in meningiomas, medulloblastomas, and bone and soft tissue sarcomas [83][84][85][86]. This review focuses on GAB1's influence on cellular transformation particularly in proliferation, evasion of apoptosis, metastasis, and angiogenesis-each of these processes being a cancer hallmark.…”
Section: Role Of Gab1 In Cancermentioning
confidence: 99%

The Role of GAB1 in Cancer

Pérez-Baena,
Cordero-Pérez,
Pérez-Losada
et al. 2023
Cancers
“…To the best of our knowledge, the role of ABL tyrosine kinases in medulloblastoma and/or LMD prior to this study was unknown, outside of a few studies observing ABL1 expression in medulloblastoma. 7 , 8 Through this work, we report that ABL1 and ABL2 mRNA are highly expressed in medulloblastoma, that pharmacologic inhibition of ABL kinases decreases medulloblastoma cell viability, that ABL kinases help regulate protein expression of the oncogenic transcription factor c-MYC, that ABL1/2 contribute to leptomeningeal tumor burden and survival in a mouse model of medulloblastoma and adhesion to the extracellular matrix protein, vitronectin, and that expression of genes related to neurodevelopment and oncogenesis differs significantly between ABL1/2 -depleted and control cells. Additionally, we describe RNA sequencing analysis of ABL1/2 -genetically depleted cells demonstrating enrichment in the epithelial-mesenchymal transition (EMT) pathway, further reinforcing the importance of ABL1 and ABL2 in the oncogenesis of medulloblastoma.…”
mentioning
confidence: 99%