Molecular Profile Sensitization to House Dust Mites as an Important Aspect for Predicting the Efficiency of Allergen Immunotherapy

Rodinkova, Victoria; Yuriev, Serhii; Kryvopustova, Mariia V; Mokin, V. B.; Kryzhanovskyi, Y. M.; Kurchenko, Andrii

doi:10.3389/fimmu.2022.848616

Cited by 20 publications

(20 citation statements)

References 17 publications

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“…In our study, we found that Der p 1, Der p 2, and Der p 23 had the highest positive rates of sIgE in the Dp-allergic population, which is consistent with a previous study [14]. Der p 1 and Der p 2 are the major components of Dp extracts and are regarded as the most important allergens.…”

Section: Discussionsupporting

confidence: 92%

Characteristics of Allergen Components of Dermatophagoides pteronyssinus in Shrimp and Mite Co-Sensitized Patients in Southern China

Zheng

Wu²,

Hu³

et al. 2023

Int Arch Allergy Immunol

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Introduction: Dermatophagoides pteronyssinus (Dp) and shrimp are common air allergens and allergenic food sources, respectively, in southern China. This study aimed to analyze the specific immunoglobulin E (sIgE) characteristics and relationships of Dp components among co-sensitized patients with Dp and shrimp. Materials and Methods: Serum samples were collected from 112 patients with Dp sensitization (61 with shrimp sensitization and 51 without) from southern China. The sIgE concentrations of Dp and shrimp crude extracts were determined by ImmunoCAP, and the sIgE of Dp allergen components (Der p 1, Der p 2, Der p 5, Der p 7, Der p 10, Der p 21, and Der p 23) was detected by protein chip. Results: Overall, in the Dp-allergic patients, Der p 1 had the highest positive rate (72.3%), followed by Der p 2 (65.2%), Der p 23 (46.4%), Der p 7 (32.14%), Der p 21 (29.46%), Der p 5 (22.32%), and Der p 10 (17.86%). Compared with that in the shrimp nonsensitized group, the positive rate of sIgE for Der p 10 (27.87% vs. 5.88%, p = 0.002) in the shrimp sensitization group was significantly higher; however, the positive rate of sIgE for Der p 7 (22.95% vs. 43.14%, p = 0.023) was significantly lower. Moreover, the concentration of sIgE for Der p 10 increased statistically in the shrimp-sensitized group. The correlation analysis also showed that shrimp sensitization was significantly correlated with Der p 10. Conclusion: Among patients with Dp sensitization, Der p 1 had the highest positive rate, followed by Der p 2 and Der p 23. Meanwhile, Der p 10 may play an important role in patients with shrimp sensitization, while Der p 7 may be the meaningful allergen component in patients with Dp sensitization alone. In general, component-resolved diagnosis technology in clinical practice can effectively guide patients with polysensitization to avoid allergic substances.

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Section: Discussionsupporting

confidence: 92%

Characteristics of Allergen Components of Dermatophagoides pteronyssinus in Shrimp and Mite Co-Sensitized Patients in Southern China

Zheng

Wu²,

Hu³

et al. 2023

Int Arch Allergy Immunol

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“…Podsumowanie: Diagnostyka molekularna alergii znacząco poprawiła swoistość i czułość diagnostyki alergii na HDM. zidentyfikowano kilka gatunków roztoczy, których antygeny mogą powodować sensytyzację, a uczulenie wobec alergenów poszczególnych gatunków dominuje w różnych populacjach [5].…”

Section: Abstraktunclassified

“…Alergeny HDM są uważane za najpowszechniejszą przyczynę astmy i alergicznego nieżytu nosa na świecie [5]. Pierwszym etapem diagnostyki uczulenia wobec HDM jest prawidłowe zebranie wywiadu, czyli ustalenie czy po kontakcie z alergenem u pacjenta występują objawy alergii.…”

Section: Opis Stanu Wiedzyunclassified

“…Obok molekuł Der p 1 oraz Der p 2 jest ona uznawana za alergen większy Dermatophagoides pteronyssinus (D. pteronyssinus), wobec którego uczulonych jest 70% pacjentów z wywiadem typowym dla alergii wobec HDM w Europie Zachodniej[12]. Zespół badawczy z Ukrainy wykazał, że uczulonych wobec Der p 23 jest 55% pacjentów z objawami alergii[5].Ze względu na standaryzację ekstraktów HDM wyłącznie w kierunku alergenów większych -Der p 1 i Der p 2 -skuteczność immunoterapii ekstraktami HDM jest niższa niż w przypadku immunoterapii ekstraktami pyłków[6,8]. Pacjenci z alergią wobec innych białek HDM, na przykład Der p 23, mogą nie odnieść korzyści z wdrożenia immunoterapii.…”

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The molecular diagnosis of house dust mite allergy: a short review

Choina¹,

Gromek²,

Wilk

et al. 2022

J Educ Health Sport

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Introduction: House dust mite (HDM) allergens are considered among the most essential elicitors of allergic rhinitis and asthma worldwide [1]. How can we determine the individual sensitization profile of a patient? Is there a way to monitor the development of allergic symptoms? Is it possible to tailor different forms of therapy based on the individual sensitization profile of a patient? Purpose: The study aims to show the benefits of molecular diagnostics of allergies based on the example of HDM allergy. Description of the state of knowledge: Clinical manifestation is the most important aspect of diagnosing HDM allergy. The determination of allergen specific immunoglobulins E (asIgE) against HDM extracts may be helpful in the identification of the cause of allergy symptoms. However, the diagnosis using allergen extracts cannot be established in all cases. What revolutionised the diagnosing process of HDM allergy is the molecular diagnostics of allergy. Based on the presence of asIgE against allergen molecules it is possible to identify the allergen responsible for the sensitisation as well as personalise the therapeutic recommendations. Summary: The molecular diagnostics of allergy significantly improved the specificity and sensitivity of HDM allergy diagnostics. Molecular diagnostics in individuals with HDM allergy make it possible to establish the individual patient’s allergy profile, and consequently personalise therapeutic recommendations. It is especially important regarding the selection of patients who may benefit from immunotherapy. The component-resolved diagnostics in allergology is a step toward personalised medicine.

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“…In our previous paper [ 18 ], we have determined that the population of Ukraine, like most European populations, is most sensitized to group 1 and 2 allergens as well as to Der p 23. However, other allergens, such as Der p 5, Der p 7, Der p 20 and Der p 21 are also relevant for the population of Ukraine.…”

Section: Introductionmentioning

confidence: 99%

Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

et al. 2023

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Background As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied, our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective. Methods The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used. Bayesian Network analysis was used to build probabilistic patterns of individual sensitization. Results Patients from Ukraine were most often sensitized to HDM allergens of group 1 (Der p 1, Der f 1) and group 2 (Der p 2, Der f 2) as well as to Der p 23 (55%). A considerable sensitivity to Der p 5, Der p 7 and Der p 21 allergens was also observed. The overall nature of sensitization to HDM allergens among the population of Ukraine is formed within the first year of life. By this time, there is a pronounced sensitization to HDM allergens of groups 1 and 2 as well as to Der p 23. Significance of sensitization to Der p 5, Der p 7 and Der p 21 allergens grows starting from the age of 3–6. Bayesian Network data analysis indicated the leading role of sensitization to Der p 1 and Der f 2. While developing the sensitivity to group 5 allergens, the leading role may belong to Der p 21 allergen. Conclusion The results obtained indicate the importance of determining the sensitization profile using the multi-component approach. A more detailed study of the optimal age for AIT prescription is required as the pattern of sensitization to HDMs is formed during the first year of life.

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Molecular Profile Sensitization to House Dust Mites as an Important Aspect for Predicting the Efficiency of Allergen Immunotherapy

Cited by 20 publications

References 17 publications

Characteristics of Allergen Components of Dermatophagoides pteronyssinus in Shrimp and Mite Co-Sensitized Patients in Southern China

Characteristics of Allergen Components of Dermatophagoides pteronyssinus in Shrimp and Mite Co-Sensitized Patients in Southern China

The molecular diagnosis of house dust mite allergy: a short review

Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

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