Molecular profiling of the gilthead sea bream (Sparus aurata L.) response to chronic exposure to the myxosporean parasite Enteromyxum leei

RNA-seq analysis of mucosal immune responses reveals signatures of intestinal barrier disruption and pathogen entry following Edwardsiella ictaluri infection in channel catfish, Ictalurus punctatus

“…We observed dramatic down-regulation (>30-fold at 3 h post infection) of nattectin, a fish C-type lectin, which has been demonstrated to induce the recruitment of specific subsets of monocytes which possess dendritic cell (DC) functions [60]. Interestingly, in one of the few previous studies of intestinal responses to infection in fish, nattectin levels were observed to be higher in disease-resistant gilthead sea bream [16]. CD209 (DC-SIGN), another C-type lectin was also down-regulated, as were MMP13 and MMP9, critical in facilitating migration of DC and monocytes to sites of infection [61].…”

“…While our knowledge of cellular actors in teleost intestinal immunology has grown considerably [14], few studies have examined the molecular processes and pathways triggered following bacterial invasion and passage through the intestinal mucosa. Jima et al [15] examined the transcriptional consequences of the lack of adaptive immunity (rag1À/À) in the zebrafish intestine, while Davey et al [16] recently profiled gilthead sea bream intestinal responses to myxosporean parasite infection. Both studies utilized microarrays to examine expression levels of known transcripts.…”

Strong effect of long-term Sparicotyle chrysophrii infection on the cellular and innate immune responses of gilthead sea bream, Sparus aurata

“…This immuno-suppression of lysozyme, complement and protease inhibition was also shown in sea bream infected with Enteromyxum spp. (Cuesta et al, 2006a;Davey et al, 2011;Sitjà-Bobadilla et al, 2008).…”

Expression of Developmental-Stage-Specific Genes in the Gilthead Sea Bream Sparus aurata L.

“…A broad range of gene expression studies using up-to-date technologies have been performed (Darias et al 2008;Sarropoulou et al 2005bSarropoulou et al , 2009). In addition, several studies have been performed in order to better understand the role of genes implicated in several physiological mechanisms such as growth rate and immune response (Davey et al 2011) along with disease resistance (Casani et al 2009), regulation of spermatogenesis (ChavesPozo et al 2005(ChavesPozo et al , 2007, and assessment of flesh quality (Menoyo et al 2004;Picone et al 2012). The most decisive period however in the production of marine fish has been determined to be during the larval stage (Pavlidis and Mylonas 2011), which is set up during embryogenesis.…”