Molecular prognostic markers in malignant mesothelioma

Kumar, Priya; Kratzke, Robert A.

doi:10.1016/j.lungcan.2005.03.012

Cited by 27 publications

(20 citation statements)

References 52 publications

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“…More recently, both proteins have been implicated in EMT through transcription factors such as Snail or Twist [22,23]. In MPM, high expression of p27 correlated with better patient's survival [24], a finding which is corroborated by our results, although without independent prognostic value.…”

Section: Discussionsupporting

confidence: 87%

Prognostic significance of epithelial–mesenchymal transition in malignant pleural mesothelioma☆☆☆

Schramm

Opitz

Thies

et al. 2010

European Journal of Cardio-Thoracic Surgery

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Section: Discussionsupporting

confidence: 87%

Prognostic significance of epithelial–mesenchymal transition in malignant pleural mesothelioma☆☆☆

Schramm

Opitz

Thies

et al. 2010

European Journal of Cardio-Thoracic Surgery

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“…Recently, Bottomley et al [125] demonstrated that some items of the EORTC-QLQ-C30/Lung Cancer 13 questionnaire were correlated with patient survival. Additionally, a very large number of biomarkers were assessed in a prognostic intent [110, 115,126,127,128,129,130], but have not been validated in large and independent samples of patients at the present time.…”

Section: Malignant Pleural Mesotheliomamentioning

confidence: 99%

Mesothelioma and Asbestos-Related Pleural Diseases

Greillier¹,

Astoul²

2008

Respiration

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At present, the use of asbestos is not regulated at a worldwide scale. Moreover, there is a latency period between asbestos exposure and the manifestations of asbestos-related diseases. Consequently, pulmonologists are still dealing with consequences of asbestos exposure, which mainly occur at the pleural surface. The aim of this review is to provide an overview of asbestos-related pleural diseases. We summarized the most relevant data for the diagnosis and the management of benign asbestos pleural effusions, pleural plaques, diffuse pleural thickening and rounded atelectasis. Special attention is dedicated to malignant pleural mesothelioma, given the challenging issues of this disease, the recent advances in its management and the dynamism of research in this area.

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“…Molecular studies at DNA and RNA levels, as well as cytogenetic studies, have resulted in identification of potential diagnostic and prognostic markers that may be useful in clinical practice [14][15][16][17]. One of the most common genetic alterations in MPM is the homozygous deletion of the 9p21 locus harboring genes CDKN2A, CDKN2B, and MTAP [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of p16/cdkn2a loss in pleural malignant mesotheliomas

Kothmaier²,

et al. 2008

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Homozygous deletion of p16/CDKN2A is the most common genetic abnormality in malignant mesotheliomas. The aim of this study was to determine prognostic significance of p16/CDKN2A loss in malignant pleural mesotheliomas (MPM) as defined by immunohistochemistry and fluorescence in situ hybridization (FISH). High-density tissue microarrays were constructed from archival formalin-fixed paraffin-embedded samples of 48 MPM. Long survival (LS) was defined as survival greater than 3 years from the time of diagnosis, and short survival was defined as less than 3 years from the time of diagnosis. Both loss of p16 protein expression by immunohistochemistry and homozygous deletion of p16 by FISH were associated with adverse prognosis. Female gender, positive p16 immunoexpression, and lack of p16/CDKN2A deletion significantly predicted the survival for the LS group. Statistical analysis showed a very strong correlation of immunohistochemistry and FISH data. Cases positive for p16 immunoexpression and negative for 9p21 deletion showed the best survival time. Our study is the first to demonstrate decreased frequency of homozygous deletion of 9p21 and loss of p16 immunoreactivity in pleural mesotheliomas from patients with long-term survival of greater than 3 years in contrast to patients with rapidly fatal mesotheliomas. A possible implementation of these tests into preoperative prognostication of MPM and therapeutic decisions should be considered.

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Molecular prognostic markers in malignant mesothelioma

Cited by 27 publications

References 52 publications

Prognostic significance of epithelial–mesenchymal transition in malignant pleural mesothelioma☆☆☆

Prognostic significance of epithelial–mesenchymal transition in malignant pleural mesothelioma☆☆☆

Mesothelioma and Asbestos-Related Pleural Diseases

Prognostic significance of p16/cdkn2a loss in pleural malignant mesotheliomas

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