Molecular Recognition and Catalysis by Molecularly Imprinted Polymer Catalysts: Thermodynamic and Kinetic Surveys on the Specific Behaviors

Tong, Kejun; Xiao, Shan; Li, Songjun; Wang, Jing

doi:10.1007/s10904-008-9217-9

Cited by 30 publications

(19 citation statements)

References 18 publications

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“…Several drugs have been used as templates to achieve polymeric devices, capable of prolonging the release profile of specific therapeutic agents with better performance as compared to more traditional drug delivery system [175]. …”

Section: Mips’ Applicationsmentioning

confidence: 99%

Molecularly Imprinted Polymers: Present and Future Prospective

Vasapollo

Sole

Mergola

et al. 2011

IJMS

908

587

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Molecular Imprinting Technology (MIT) is a technique to design artificial receptors with a predetermined selectivity and specificity for a given analyte, which can be used as ideal materials in various application fields. Molecularly Imprinted Polymers (MIPs), the polymeric matrices obtained using the imprinting technology, are robust molecular recognition elements able to mimic natural recognition entities, such as antibodies and biological receptors, useful to separate and analyze complicated samples such as biological fluids and environmental samples. The scope of this review is to provide a general overview on MIPs field discussing first general aspects in MIP preparation and then dealing with various application aspects. This review aims to outline the molecularly imprinted process and present a summary of principal application fields of molecularly imprinted polymers, focusing on chemical sensing, separation science, drug delivery and catalysis. Some significant aspects about preparation and application of the molecular imprinting polymers with examples taken from the recent literature will be discussed. Theoretical and experimental parameters for MIPs design in terms of the interaction between template and polymer functionalities will be considered and synthesis methods for the improvement of MIP recognition properties will also be presented.

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Section: Mips’ Applicationsmentioning

confidence: 99%

Molecularly Imprinted Polymers: Present and Future Prospective

Vasapollo

Sole

Mergola

et al. 2011

IJMS

908

587

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“…Dynamic adsorbing-desorbing cyclic voltammetry (DCV) can provide valuable information on the binding behavior between nanoreactors and substrates. [24,25] As shown in Figure 8, the NP, NPA, and DNP bound to MIP-Ag-NP exhibited reduction potentials at À921, À919 and À715 mV, respectively. The MIPAg-NP showed the strongest interaction with the template molecule, as desired.…”

Section: Dynamic Binding Behaviormentioning

confidence: 96%

A Substrate‐Selective Nanoreactor Made of Molecularly Imprinted Polymer Containing Catalytic Silver Nanoparticles

Gong

2009

Adv Funct Materials

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An original, substrate‐selective nanoreactor is designed and characterized. The nanoreactor made of a 4‐nitrophonel (NP)‐imprinted polymer and Ag nanoparticles, can specifically recognize NP compared with its analogues 4‐nitrophenyl acetate (NPA) and 2,6‐dimethyl‐4‐nitrophenol (DNP). Under comparable conditions, this nanoreactor significantly accelerated the reduction of NP; however, much less acceleration is shown for its analogues. Unlike traditional Ag nanoreactors, which lack molecular recognition abilities, this unique nanoreactor is composed of molecularly imprinted networks, making substrate‐selective catalysis feasible.

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“…Consequently, the potential applications of MIPs are related to the areas, where the role of noncovalent interactions is well established . A wide variety of review papers can be found focusing on applications of MIPs, including those on the topics of chemical analysis and detection, affinity separation and purification, drug delivery, and catalysis …”

Section: Introductionmentioning

confidence: 99%

“…7,[12][13][14] A wide variety of review papers can be found focusing on applications of MIPs, including those on the topics of chemical analysis and detection, 15,16 affinity separation and purification, 7,17,18 drug delivery, 19,20 and catalysis. [21][22][23][24][25] In the last few decades, the interest in the field of macromolecular imprinting, resulting in MIPs capable of selective recognition of the specific macromolecules, eg, proteins, viruses, and cells, in a complex medium, has considerably increased because of the great demand in clinical diagnostics and therapies aiming at replacement of expensive and readily degradable biological recognition elements. 1,8,9,[26][27][28] The presence in a macromolecular template like a protein of a considerable amount of different functional groups creates potential premises for multiple noncovalent interactions (H-bond, van der Waals, electrostatic, and hydrophobic) between the protein and functional monomers in a prepolymerization complex before protein-MIP synthesis.…”

Section: Introductionmentioning

confidence: 99%

A computational approach to study functional monomer-protein molecular interactions to optimize protein molecular imprinting

et al. 2017

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Molecular imprinting has become a promising approach for synthesis of polymeric materials having binding sites with a predetermined selectivity for a given analyte, the so-called molecularly imprinted polymers (MIPs), which can be used as artificial receptors in various application fields. Realization of binding sites in a MIP involves the formation of prepolymerization complexes between a template molecule and monomers, their subsequent polymerization, and the removal of the template. It is believed that the strength of the monomer-template interactions in the prepolymerization mixture influences directly on the quality of the binding sites in a MIP and consequently on its performance. In this study, a computational approach allowing the rational selection of an appropriate monomer for building a MIP capable of selectively rebinding macromolecular analytes has been developed. Molecular docking combined with quantum chemical calculations was used for modeling and comparing molecular interactions among a model macromolecular template, immunoglobulin G (IgG), and 1 of 3 electropolymerizable functional monomers: m-phenylenediamine (mPD), dopamine, and 3,4-ethylenedioxythiophene, as well as to predict the probable arrangement of multiple monomers around the protein. It was revealed that mPD was arranged more uniformly around IgG participating in multiple H-bond interactions with its polar residues and, therefore, could be considered as more advantageous for synthesis of a MIP for IgG recognition (IgG-MIP). These theoretical predictions were verified by the experimental results and found to be in good agreement showing higher binding affinity of the mPD-based IgG-MIP toward IgG as compared with the IgG-MIPs generated from the other 2 monomers.

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Molecular Recognition and Catalysis by Molecularly Imprinted Polymer Catalysts: Thermodynamic and Kinetic Surveys on the Specific Behaviors

Cited by 30 publications

References 18 publications

Molecularly Imprinted Polymers: Present and Future Prospective

Molecularly Imprinted Polymers: Present and Future Prospective

A Substrate‐Selective Nanoreactor Made of Molecularly Imprinted Polymer Containing Catalytic Silver Nanoparticles

A computational approach to study functional monomer-protein molecular interactions to optimize protein molecular imprinting

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