Molecular Recognition of a Three‐Way DNA Junction by a Metallosupramolecular Helicate

Oleksy, Aneta; Blanco, Alexandre G.; Boer, Roeland; Usón, Isabel; Aymamı́, Joan; Rodger, Alison; Hannon, Michael J.; Coll, Miquel

doi:10.1002/anie.200503822

Cited by 286 publications

(172 citation statements)

References 42 publications

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“…Oleksi et al (39) have reported the crystallization of a threeway DNA junction around a dinuclear iron(II) supramolecular helicate. Each of the three DNA strands are kinked in the center by some 60°between adjacent Tand A bases, with which the polypyridyl ligands of the complex make stacking interactions, thus opening up a cavity in which to accommodate the tetracationic helicate.…”

Section: Discussionmentioning

confidence: 99%

Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand

Hall

O'Sullivan

Naseer

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

129

140

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We describe a crystal structure, at atomic resolution (1.1 Å, 100 K), of a ruthenium polypyridyl complex bound to duplex DNA, in which one ligand acts as a wedge in the minor groove, resulting in the 51°kinking of the double helix. The complex cation Λ-½Ruð1,4,5,8-tetraazaphenanthreneÞ 2 ðdipyridophenazineÞ 2þ crystallizes in a 1∶1 ratio with the oligonucleotide d(TCGGCGCCGA) in the presence of barium ions. Each complex binds to one duplex by intercalation of the dipyridophenazine ligand and also by semiintercalation of one of the orthogonal tetraazaphenanthrene ligands into a second symmetrically equivalent duplex. The result is noncovalent cross-linking and marked kinking of DNA.DNA oligonucleotide | ruthenium complex | X-ray crystal structure

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Section: Discussionmentioning

confidence: 99%

Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand

Hall

O'Sullivan

Naseer

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

129

140

View full text Add to dashboard Cite

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“…电相互作用, 面对面插入型的 π-π 堆积作用, C-H…X 型氢键相互作用和小沟的夹心作用 [65] . 作者还发现 [Fe 2 26 3 ] 4＋超分子螺旋体可以大量提取质粒 DNA, 比常规 DNA 浓缩剂更有效, 而且还可以抑制 DNA 相关酶的活性 [66] .…”

Section: 含硫含氮配体形成的双螺旋unclassified

Progress in Helicates Directed by Metal Coordination

Jiang¹,

Li²,

Wang³

2018

Chin. J. Org. Chem.

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“…The latter displayed the ability to induce conformational changes in the DNA decamer [d(GACGGCCGTC) 2 ] [5]. Hannon also showed that this triply stranded helicate non-covalently binds at the centre of three-way (Y-shaped) DNA [6][7][8][9] and RNA [10] 4+ helicates have been found to display micromolar cytotoxicity against a range of cancer cell lines [11,12] 4+ helicate has been shown to display modest antibacterial activity against Bacillus subtilis (minimum inhibitory concentration (MIC) = 32 µg·mL −1 ) and Escherichia coli (MIC = 64 µg·mL −1 ) [13].…”

Section: Introductionmentioning

confidence: 99%

Oxidatively Locked [Co2L3]6+ Cylinders Derived from Bis(bidentate) 2-Pyridyl-1,2,3-triazole “Click” Ligands: Synthesis, Stability, and Antimicrobial Studies

et al. 2016

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Abstract:A small family of [Co 2 (L pytrz ) 3 ] 6+ cylinders was synthesised from bis(bidentate) 2-pyridyl-1,2,3-triazole "click" ligands (L pytrz ) through an "assembly-followed-by-oxidation" method. The cylinders were characterised using 1 H, 13 C, and DOSY NMR, IR, and UV-Vis spectroscopies, along with electrospray ionisation mass spectrometry (ESMS). Stability studies were conducted in dimethyl sulfoxide (DMSO) and D 2 O. In contrast to similar, previously studied, [Fe 2 (L pytrz ) 3 ] 4+ helicates the more kinetically inert [Co 2 (L pytrz ) 3 ] 6+ systems proved stable (over a period of days) when exposed to DMSO and were even more stable in D 2 O. The triply stranded [Co 2 (L pytrz ) 3 ] 6+ systems and the corresponding "free" ligands were tested for antimicrobial activity in vitro against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) microorganisms. Agar-based disk diffusion and Mueller-Hinton broth micro-dilution assays showed that the [Co 2 (L pytrz ) 3 ] 6+ cylinders were not active against either strain of bacteria. It is presumed that a high charge of the [Co 2 (L pytrz ) 3 ] 6+ cylinders is preventing them from crossing the bacterial cell membranes, rendering the compounds biologically inactive.

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Molecular Recognition of a Three‐Way DNA Junction by a Metallosupramolecular Helicate

Abstract: Three point turn: A metallosupramolecular helicate with trigonal‐antiprismatic geometry fits perfectly into the central hydrophobic cavity of a three‐way DNA junction allowing a new mode of DNA recognition.

Cited by 286 publications

References 42 publications

Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand

Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand

Progress in Helicates Directed by Metal Coordination

Oxidatively Locked [Co2L3]6+ Cylinders Derived from Bis(bidentate) 2-Pyridyl-1,2,3-triazole “Click” Ligands: Synthesis, Stability, and Antimicrobial Studies

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