Molecular regulation of glutamate and GABA transporter proteins by clobazam during epileptogenesis in Fe+++-induced epileptic rats

Doi, Taku; Ueda, Yuto; Tokumaru, Jun; Willmore, L. James

doi:10.1016/j.molbrainres.2005.09.010

Cited by 33 publications

(26 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous Western blot analyses of hippocampal tissue from various epilepsy models also demonstrated unchanged GAT-1 levels (Doi et al, 2005(Doi et al, , 2009Lee et al, 2006). As severe HS is characterized by an overall neuronal loss, a compensatory upregulation of GAT-1 in the remaining neurons may be expected.…”

Section: Western Blotmentioning

confidence: 87%

Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis

Schijns

Karaca

Andrade

et al. 2015

Journal of Chemical Neuroanatomy

View full text Add to dashboard Cite

Section: Western Blotmentioning

confidence: 87%

Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis

Schijns

Karaca

Andrade

et al. 2015

Journal of Chemical Neuroanatomy

View full text Add to dashboard Cite

“…Patients with temporal lobe epilepsy showed a decreased response of GABA release to elevated extracellular Glu level, supporting the hypothesis that reversed transport of GABA plays an important role in avoiding epileptic seizures. It is very exciting in this context that clobazam, a clinically effective antiepileptic drug is found to up-regulate expression of minor GABA and Glu transporters [34]. Clobazam treatment of rats with FeCl 3 -induced chronic, spontaneous recurrent seizures resulted in the up-regulation of both EAAT3 and mGAT4 (rGAT-3) in the contralateral hippocampus [34].…”

Section: Reversed Transportmentioning

confidence: 99%

Role for GABA and Glu Plasma Membrane Transporters in the Interplay of Inhibitory and Excitatory Neurotransmission

Héja

Karacs

Kardos

2006

CTMC

View full text Add to dashboard Cite

Neurotransmitter plasma membrane transporters do have much more to perform than simply terminating synaptic transmission and replenishing neurotransmitter pools. Findings in the past decade have evidenced their function in maintaining physiological synaptic excitability, and their actions in critical or pathological conditions, also. Conclusively these findings indicated a previously unrecognized role for neurotransmitter plasma membrane transporters in both, synaptic and nonsynaptic signaling. Major inhibitory and excitatory neurotransmitters within the brain, GABA and Glu, have long been considered to operate through independent systems (GABAergic or Gluergic), each of them characterized by its own localization, function and dedicated GABAergic or Gluergic cell phenotypes. Recent advances, however, have challenged this long-standing paradigm. Localization of GABA in Gluergic terminals and Glu in GABAergic cells were reported. Specific plasma membrane transporters for GABA and Glu are also co-localized in different brain areas. Although, their role in regulating each other's signal is still far from being understood, emerging lines of evidence on interplaying GABAergic and Gluergic processes through plasma membrane transporters opens up a new avenue in the field of more specific therapeutic intervention.

show abstract

“…Moreover, CLB increases the expression of glutamate transporter protein 1 and GABA transporter protein 3 in the brain [22]. It should be mentioned that CLB, like other 1,5-benzodiazepines (e.g.…”

Section: Discussionmentioning

confidence: 99%

Additive Interactions between 1-Methyl-1,2,3,4-Tetrahydroisoquinoline and Clobazam in the Mouse Maximal Electroshock-Induced Tonic Seizure Model - An Isobolographic Analysis for Parallel Dose-Response Relationship Curves

Andres-Mach¹,

Haratym-Maj²,

Zagaja³

et al. 2014

Pharmacology

View full text Add to dashboard Cite

Background: The aim of this study was to characterize the anticonvulsant effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTHIQ) in combination with clobazam (CLB) in the mouse maximal electroshock-induced seizure (MES) model. Methods: The anticonvulsant interaction profile between 1-MeTHIQ and CLB in the mouse MES model was determined using an isobolographic analysisfor parallel dose-response relationship curves. Results: Electroconvulsions were produced in albino Swiss mice by a current (sine wave, 25 mA, 500 V, 50 Hz, 0.2-second stimulus duration) delivered via auricular electrodes by a Hugo Sachs generator. There was an additive effect of the combination of 1-MeTHIQ with CLB (at the fixed ratios of 1:3, 1:1 and 3:1) in the mouse MES-induced tonic seizure model. Conclusions: The additive interaction of the combination of 1-MeTHIQ with CLB (at fixed-ratios of 1:3, 1:1 and 3:1) in the mouse MES model seems to be pharmacodynamic in nature and worth of considering in further clinical practice.

show abstract

Molecular regulation of glutamate and GABA transporter proteins by clobazam during epileptogenesis in Fe+++-induced epileptic rats

Cited by 33 publications

References 25 publications

Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis

Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis

Role for GABA and Glu Plasma Membrane Transporters in the Interplay of Inhibitory and Excitatory Neurotransmission

Additive Interactions between 1-Methyl-1,2,3,4-Tetrahydroisoquinoline and Clobazam in the Mouse Maximal Electroshock-Induced Tonic Seizure Model - An Isobolographic Analysis for Parallel Dose-Response Relationship Curves

Contact Info

Product

Resources

About