Abstract:Tyroservatide (YSV) belongs to a class of bioactive peptides that have drawn considerable attention in the field of drug discovery, yet it displays limited potency and often requires a millimolar...
“… 155–158 Liu et al synthesized a novel octapeptide (1-YSV) to enable its co-assembly with HCPT to obtain supramolecular hydrogels with excellent viscoelasticity and increased the water stability of HCPT ( Figure 4 ). 159 Guo et al prepared a supramolecular hydrogel composed of a self-assembling peptide, HCPT and macrocyclic polyamine cyclen can depleting cellular ATP and reversing ATP-dependent drug efflux, greatly improving cellular uptake and nuclear aggregation of HCPT. 160 Figure 4 ( A ) Schematic illustration of co-assembly of tyroservatide-derived octapeptide (1-YSV) and HCPT for cancer therapy; ( B ) TEM micrograph of the 1-YSV hydrogel; and ( C ) TEM micrograph of the 1-YSV/HCPT hydrogel.…”
Section: Organic Npsmentioning
confidence: 99%
“…[155][156][157][158] Liu et al synthesized a novel octapeptide (1-YSV) to enable its co-assembly with HCPT to obtain supramolecular hydrogels with excellent viscoelasticity and increased the water stability of HCPT (Figure 4). 159 Guo et al prepared a supramolecular hydrogel composed of a self-assembling peptide, HCPT and macrocyclic polyamine cyclen can depleting cellular ATP and reversing ATP-dependent drug efflux, greatly improving cellular uptake and nuclear aggregation of HCPT.…”
10-Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as instability of the lactone ring and insolubility in water have limited the clinical application of this drug. In recent years, unprecedented advances in biomedical nanotechnology have facilitated the development of nano drug delivery systems. It has been found that nanomedicine can significantly improve the stability and water solubility of HCPT. NanoMedicines with different diagnostic and therapeutic functions have been developed to significantly improve the anticancer effect of HCPT. In this paper, we collected reports on HCPT nanomedicines against tumors in the past decade. Based on current research advances, we dissected the current status and limitations of HCPT nanomedicines development and looked forward to future research directions.
“… 155–158 Liu et al synthesized a novel octapeptide (1-YSV) to enable its co-assembly with HCPT to obtain supramolecular hydrogels with excellent viscoelasticity and increased the water stability of HCPT ( Figure 4 ). 159 Guo et al prepared a supramolecular hydrogel composed of a self-assembling peptide, HCPT and macrocyclic polyamine cyclen can depleting cellular ATP and reversing ATP-dependent drug efflux, greatly improving cellular uptake and nuclear aggregation of HCPT. 160 Figure 4 ( A ) Schematic illustration of co-assembly of tyroservatide-derived octapeptide (1-YSV) and HCPT for cancer therapy; ( B ) TEM micrograph of the 1-YSV hydrogel; and ( C ) TEM micrograph of the 1-YSV/HCPT hydrogel.…”
Section: Organic Npsmentioning
confidence: 99%
“…[155][156][157][158] Liu et al synthesized a novel octapeptide (1-YSV) to enable its co-assembly with HCPT to obtain supramolecular hydrogels with excellent viscoelasticity and increased the water stability of HCPT (Figure 4). 159 Guo et al prepared a supramolecular hydrogel composed of a self-assembling peptide, HCPT and macrocyclic polyamine cyclen can depleting cellular ATP and reversing ATP-dependent drug efflux, greatly improving cellular uptake and nuclear aggregation of HCPT.…”
10-Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as instability of the lactone ring and insolubility in water have limited the clinical application of this drug. In recent years, unprecedented advances in biomedical nanotechnology have facilitated the development of nano drug delivery systems. It has been found that nanomedicine can significantly improve the stability and water solubility of HCPT. NanoMedicines with different diagnostic and therapeutic functions have been developed to significantly improve the anticancer effect of HCPT. In this paper, we collected reports on HCPT nanomedicines against tumors in the past decade. Based on current research advances, we dissected the current status and limitations of HCPT nanomedicines development and looked forward to future research directions.
“…For example, a peptide-sequence screening for hydrogelation yielded the octapeptide FKFEYYSV, composed of the bioactive tripeptide YSV and the gelation moiety FKFEY which also increased the anticancer activity of YSV. In addition, hydroxycamptothecin was loaded on the hydrogel for simultaneous drug delivery, and the whole system showed good anticancer activity, without toxicity for non-cancerous cells [85]. A similar combined approach was developed using an EYSV peptide linked to taxol (taxol-EYSV) [86].…”
Proteins are functional building blocks of living organisms that exert a wide variety of functions, but their synthesis and industrial production can be cumbersome and expensive. By contrast, short peptides are very convenient to prepare at a low cost on a large scale, and their self-assembly into nanostructures and gels is a popular avenue for protein biomimicry. In this Review, we will analyze the last 5-year progress on the incorporation of bioactive motifs into self-assembling peptides to mimic functional proteins of the extracellular matrix (ECM) and guide cell fate inside hydrogel scaffolds.
“…This significantly improved photothermal effect is attributed to the abundant oxygen vacancies on the surface of the ultrathin MnO 2 nanosheets, which was confirmed by the extended X‐ray absorption fine structure (EXAFS) data and density functional theory (DFT) calculation. Recently, Liu et al [ 162 ] reported that the enzymatically synthesized MnO 2 nanoparticles (Bio‐MnO 2 NPs) had extremely high photothermal conversion efficiency (44%) and showed excellent thermal cycle stability and solubility. This nanoparticle is prepared through an enzyme‐mediated biomineralization process, and the hexagonal layer symmetry of Bio‐MnO 2 NPs is a key feature to achieve the high photothermal conversion efficiency, which may be due to the abundant cation vacancies and rich oxygen permeation.…”
Advancements in nanotechnology have promoted the rapid development of diverse nanosystems for biomedical applications. Manganese dioxide (MnO2) nanomaterials have attracted numerous attentions in the field of biosensing and cancer treatment due to their unique properties, such as simple fabrication procedures, broad optical absorption, and high oxidation and catalytic ability. Especially, the intelligent stimuli‐responsiveness of MnO2 nanomaterials to tumor microenvironment (TME) greatly improves their performance in tumor imaging and cancer therapy. In this review, the synthetic methods of different MnO2 nanostructures (nanoparticles, nanosheets, and nanoflowers) are first introduced, followed by the introduction of MnO2 nanomaterials for various biosensing applications based on their unique characteristics. Then, the recent achievements and progress of MnO2 nanomaterials for cancer treatment are comprehensively summarized with a focus on various therapeutic enhancements profiting from their disassembled ingredients under TME guidance. Finally, the current challenges and future perspectives of this promising research are discussed in the fields of biomedicine.
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