Molecular simulation of pyrroloquinoline quinine-dependent glycerol dehydrogenase in<i>Gluconobacter oxydans</i>

Wu, Xin-Sen; Xia, Zhendong; Yang, Xingyuan; Xue, Chuang; Lü, Wenyu

doi:10.1080/08927022.2012.682281

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first structure of the enterobacterial GDH from Serratia was reported [ 154 ], which is helpful in the study of the diseases caused by gut microbes. The molecular dynamic simulation of the constructed three-dimensional structure of sldha was performed using Gromacs 4.0.5 [ 156 ]. This information from the three-dimensional structure of GDH would be beneficial in improving the GDH’s properties using the genetic engineering methods of the GDHt in the Fig.…”

Section: Glycerol Dehydrogenasementioning

confidence: 99%

Key enzymes catalyzing glycerol to 1,3-propanediol

Jiang

Wang

et al. 2016

Biotechnol Biofuels

View full text Add to dashboard Cite

Biodiesel can replace petroleum diesel as it is produced from animal fats and vegetable oils, and it produces about 10 % (w/w) glycerol, which is a promising new industrial microbial carbon, as a major by-product. One of the most potential applications of glycerol is its biotransformation to high value chemicals such as 1,3-propanediol (1,3-PD), dihydroxyacetone (DHA), succinic acid, etc., through microbial fermentation. Glycerol dehydratase, 1,3-propanediol dehydrogenase (1,3-propanediol-oxydoreductase), and glycerol dehydrogenase, which were encoded, respectively, by dhaB, dhaT, and dhaD and with DHA kinase are encompassed by the dha regulon, are the three key enzymes in glycerol bioconversion into 1,3-PD and DHA, and these are discussed in this review article. The summary of the main research direction of these three key enzyme and methods of glycerol bioconversion into 1,3-PD and DHA indicates their potential application in future enzymatic research and industrial production, especially in biodiesel industry.

show abstract

Section: Glycerol Dehydrogenasementioning

confidence: 99%