Molecular structure of human aortic valve by µSR- FTIR microscopy

Borkowska, Anna; Nowakowski, Michał; Lis, Grzegorz; Wehbe, Katia; Cinque, Gianfelice; Kwiatek, Wojciech M.

doi:10.1016/j.nimb.2017.06.021

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Figure 2b demonstrates the FTIR spectra of the CA and CA-Li. As all the carbon atoms in CA molecules are of sp 2 hybridization, the appearance of sp 3 C-H bond indicates the cleavage and polymerization of the C=C double bond by reaction with Li, forming CA-Li 35 . In Fig.…”

Section: Resultsmentioning

confidence: 99%

Constructing multifunctional solid electrolyte interface via in-situ polymerization for dendrite-free and low N/P ratio lithium metal batteries

et al. 2021

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Stable solid electrolyte interface (SEI) is highly sought after for lithium metal batteries (LMB) owing to its efficient electrolyte consumption suppression and Li dendrite growth inhibition. However, current design strategies can hardly endow a multifunctional SEI formation due to the non-uniform, low flexible film formation and limited capability to alter Li nucleation/growth orientation, which results in unconstrained dendrite growth and short cycling stability. Herein, we present a novel strategy to employ electrolyte additives containing catechol and acrylic groups to construct a stable multifunctional SEI by in-situ anionic polymerization. This self-smoothing and robust SEI offers multiple sites for Li adsorption and steric repulsion to constrain nucleation/growth process, leading to homogenized Li nanosphere formation. This isotropic nanosphere offers non-preferred Li growth orientation, rendering uniform Li deposition to achieve a dendrite-free anode. Attributed to these superiorities, a remarkable cycling performance can be obtained, i.e., high current density up to 10 mA cm−2, ultra-long cycle life over 8500 hrs operation, high cumulative capacity over 4.25 Ah cm−2 and stable cycling under 60 °C. A prolonged lifespan can also be achieved in Li-S and Li-LiFePO4 cells under lean electrolyte content, low N/P ratio or high temperature conditions. This facile strategy also promotes the practical application of LMB and enlightens the SEI design in related fields.

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Section: Resultsmentioning

confidence: 99%

Constructing multifunctional solid electrolyte interface via in-situ polymerization for dendrite-free and low N/P ratio lithium metal batteries

et al. 2021

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“…In particular, the presence of apatitic structures in the 7-week aortic valve, along with changes in protein structure conformation, lipids, nucleic acids (DNA, RNA), and carbohydrates, was detected (Fig. 1y, Table S8) 15 . Of note, a low degree of crystallinity in apatites is typically associated with water molecules, resulting in pronounced absorption within the 3000-3700 cm − 1 range 16 .…”

Section: Development Of Calci C Aortic Valve Stenosis and Phenotypic ...mentioning

confidence: 95%

Multiomics coupled with vibrational spectroscopy identify early mechanisms of experimental aortic valve stenosis

Anousakis-Vlachochristou,

Mavroidis,

Miliotis

et al. 2024

Preprint

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Calcific aortic valve stenosis (CAVS), characterized by calcium deposition in the aortic valve in a multiannual process, is associated with high mortality and morbidity. To understand phenomena at its early stages, reliable animal models are needed. Here, we used a critically revised high-fat vitamin D2 diet rabbit model to unveil the earliest in vivo-derived mechanisms linked to CAVS progression. We modeled the inflammation-calcification temporal pattern seen in human disease and investigated molecular changes before inflammation. Coupling comprehensive multiomics and vibrational spectroscopy revealed that among the many procedures involved, mechanotransduction, peroxisome activation, DNA damage-response, autophagy, phospholipid signaling, native ECM proteins upregulation, protein cross-linking and self-folding, are the most relevant driving mechanisms. Activation of Complement 3 receptor, Immunoglobulin J and TLR6 were the earliest signs of inflammation. Among several identified key genes were AXIN2, FOS, and JUNB. Among 10 identified miRNAs, miR-21-5p and miR-204-5p dominated fundamental cellular processes, phenotypic transition, inflammatory modulation, and were validated in human samples. The enzymatic biomineralization process mediated by TNAP was complemented by V-type proton ATPase overexpression, and the substitution of Mg-pyrophosphate with Ca-pyrophosphate. These data extend our understanding on CAVS progression, facilitate the refinement of pathophysiological hypotheses and provide a basis for novel pharmaceutical therapy investigations.

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“…Geometry of individual fibers is the reason that the material shows strongly nonlinear elastic properties. The external layers are a mechanism responsible for transferring loads to other structures during the valve work cycle (Borkowska et al, 2017). During aortic valve functioning, the material undergoes large deformations, reaching up to sixty percent (Ghista and Reul, 1983;Bosi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Dynamic analysis of the aortic valve functioning

Patralski¹

2020

Journal of Theoretical and Applied Mechanics

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The aim of the paper was to recognize the influence of mechanical factors on the movement of the leaflets. Mechanical stimuli may have a positive effect on remodeling the leaflet material to adapt its structure to a changing load. A model of the valve functioning process was developed. A geometric model similar to the construction of a natural valve was adopted. The hybrid process of the liquid-solid interaction problem was described. The interaction process was modeled. The problem was formulated with the Galerkin FEM method. Numerical analyses of a single valve work cycle and the calcification process of aortic valve bioprostheses were performed.

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Molecular structure of human aortic valve by µSR- FTIR microscopy

Cited by 3 publications

References 29 publications

Constructing multifunctional solid electrolyte interface via in-situ polymerization for dendrite-free and low N/P ratio lithium metal batteries

Constructing multifunctional solid electrolyte interface via in-situ polymerization for dendrite-free and low N/P ratio lithium metal batteries

Multiomics coupled with vibrational spectroscopy identify early mechanisms of experimental aortic valve stenosis

Dynamic analysis of the aortic valve functioning

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