Molecular Subtypes of Breast Cancer in South Asian Population by Immunohistochemical Profile and Her2neu Gene Amplification by FISH Technique: Association with other Clinicopathologic Parameters

Hashmi, Atif Ali; Edhi, Muhammad Muzzammil; Naqvi, Hanna; Khurshid, Amna; Faridi, Naveen

doi:10.1111/tbj.12329

Cited by 23 publications

(20 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 In this study, significant association (p <0.05) was found between skin involvement, lymph node involvement, necrosis and histological grade when compared with ALK, whereas histological type and vascular invasion were found to be insignificant when compared with ALK positivity. In the present study, invasive ductal carcinoma was found in 73 (58.4%), invasive medullary carcinoma in 5 23 Another study by Sheikh et al, showed similar results with present study that no significant association (p-value 0.465) was found in different histological grades with HER2/neu in which grade-I was found in 5 (71.4%), grade-II in 47 (68.1%) and grade-III in 24 (57.1%) patients. 25 In this study, skin involvement in relation with HER-2/neu was present in 19 (32.8%) patients with insignificant p-value of 0.269.…”

Section: Discussionsupporting

confidence: 56%

Expression of anaplastic lymphokinase and HER2/neu immunostaining in patients with breast carcinoma

Ali¹,

Qureshi²,

Fahim³

et al. 2018

Int J Res Med Sci

View full text Add to dashboard Cite

Background: The diagnosis and prognosis of breast cancer is done with various immunomarkers including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2/neu), and Ki-67. The diagnostic utility of Anaplastic Lymphokinase (ALK) and HER2/neu should be explored for better management of breast carcinoma patients. So, the present study was designed to determine the expression of immunostaining with ALK and HER2/neu in patients with breast cancer and to compare the association of ALK expression and HER2/neu with clinicopathological parameters.Methods: This is a cross sectional multicenter study carried out from October 2016 to March 2017. A total of 140 subjects having breast carcinoma by using non-probability purposive sampling technique were selected. After taking informed consent, tissue samples were taken from received specimen of mastectomy for hematoxylin and eosin stain. The immunohistochemistry for ALK and HER2/neu were assessed on the paraffin blocks of the tumor.Results: Out of total 140 cases invasive ductal carcinoma (89%), invasive lobular carcinoma (8%), invasive medullary carcinoma (2.1%) and papillary carcinoma (0.7%) were seen. ALK expression was positive in 81 patients (58%) while HER2/neu expression was positive in 53 cases (38%). Significant association was observed between ALK expression with histological grade, lymph node involvement, skin involvement and necrosis. There was also a significant association was seen between HER2/neu expression with lymph node metastasis and necrosis.Conclusions: Present study shows higher expression of ALK when compared to HER2/neu expression in breast cancer patients.

show abstract

Section: Discussionsupporting

confidence: 56%

Expression of anaplastic lymphokinase and HER2/neu immunostaining in patients with breast carcinoma

Ali¹,

Qureshi²,

Fahim³

et al. 2018

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…Due to lack of cancer registries in our country, the demographics of ovarian cancer are poorly understood. Various studies conducted in our population revealed a lower age group distribution of breast cancer in this part of the world due to probable BRCA mutations may play a role in young age ovarian cancer as well [ 4 ]. Liaquat National Hospital is one of the largest tertiary care centre of the province and represents both rural and urban patient population of all age groups, therefore lower age distribution of ovarian cancer in our study don’t represent hospital demographics.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic features of ovarian neoplasms with emphasis on borderline ovarian tumors: an institutional perspective

et al. 2016

Self Cite

View full text Add to dashboard Cite

BackgroundOvarian cancer is the most lethal gynecologic malignancy and it represents third most common malignancy in Karachi (after breast and oral cancer). Due to lack of well established cancer registry in our country, changing trends of ovarian tumors has not been determined. Therefore we aimed to establish the current trends and classification of ovarian tumors in our setup according to latest WHO guidelines.MethodsWe retrospectively analyzed 162 cases of ovarian tumors that underwent surgical resection from January 2009 till December 2014. Specimens were received in histopathology department, Liaquat National hospital and cases were examined by senior histopathologists and classified according to latest WHO guidelines. Various histopathologic parameters including capsular invasion, omental and lymph node meatstasis along with uterine and fallopian tube involvement were determined apart from tumor type and grade.ResultsMean age at diagnosis was 35.8 years (± 15.5). surface epithelial tumors were most common, 109 cases (67.2 %) followed by germ cell tumors, 44 cases (27.1 %) and sex cord stromal tumors, 8 cases (4.9 %). Serous tumors were most common surface epithelial tumors with 90 % benign morphology. On the other hand, mucinous tumors showed a higher percentage of borderline and malignant features (16.7 and 14.6 % respectively). Higher incidence of capsular invasion and omental metastasis was noted in endometroid and serous carcinoma compared to mucinous tumors.ConclusionsWe noted a higher frequency of young age ovarian cancers in our set up. Serous and endometroid carcinomas were found to be associated with adverse prognostic factors like capsular invasion and omental metastasis. Moreover a significantly higher proportion of ovarian tumors constitute mucinous histology including borderline tumors. Whether this represents a changing trend towards biology of these tumors in this part of the world needs to be uncovered by further studies.

show abstract

“…On account of this heterogeneity, therapeutic regimens must be tailored to the loco-regional breast cancer profiles. Studies have demonstrated a different behavior of breast cancer in Pakistan with higher prevalence in a younger age group with aggressive nature and poor survival rates [ 8 – 10 ]. Therefore, we aimed to determine prognostic parameters of luminal breast cancers in our population which can help in devising targeted and personalized therapeutic regimens tailored to the needs of the loco-regional population.…”

Section: Introductionmentioning

confidence: 99%

Prognostic parameters of luminal A and luminal B intrinsic breast cancer subtypes of Pakistani patients

et al. 2018

Self Cite

View full text Add to dashboard Cite

BackgroundPrognosis of breast cancer and success of therapeutic interventions largely rely on the clinico-pathologic and biological characteristics of the tumor and vary due to the heterogeneous nature of breast cancers. The aim of this study was to determine the frequency and prognostic parameters of luminal breast cancers in our population to devise targeted and personalized therapeutic regimens tailored to the needs of the loco-regional population.MethodsA retrospective cross-sectional study including 1951 cases of primary breast cancer treated at Liaquat National Hospital Karachi was conducted during the year 2011–2016. The clinico-pathologic characteristics were observed and semiquantitative immunohistochemical analysis was performed to study the luminal subtypes A and B. The cross-tabulated statistics of the observed characteristics were performed between the two subtypes. The significance level of each characteristic was estimated utilizing the chi-square test.ResultsLuminal cancers comprised 62.7% of the total number of cases diagnosed with breast cancers in the study period. Out of these 1224 cases of luminal cancers, 845 cases (69%) were luminal B, while 379 (31%) cases were of luminal A. Luminal B cancers were significantly more common in younger age groups as compared to luminal A cancers. Comparison of the two subtypes of luminal breast cancers revealed significant differences. Luminal B cancers were associated with higher grade (26% grade III in luminal B compared to 8% in luminal A), micropapillary histology, and high frequency of nodal metastasis (54 vs. 43%).ConclusionsLuminal B comprised the most frequent subtype of breast cancer in our study and they were found more constantly in a younger age group. Moreover, they were associated with adverse clinico-histologic parameters like higher grade and nodal metastasis. Therefore, we suggest that, despite lack of widespread availability of molecular studies in our setup, IHC-based typing should be done in every case of breast cancer to individualize therapy.

show abstract

Molecular Subtypes of Breast Cancer in South Asian Population by Immunohistochemical Profile and Her2neu Gene Amplification by FISH Technique: Association with other Clinicopathologic Parameters

Cited by 23 publications

References 48 publications

Expression of anaplastic lymphokinase and HER2/neu immunostaining in patients with breast carcinoma

Expression of anaplastic lymphokinase and HER2/neu immunostaining in patients with breast carcinoma

Clinicopathologic features of ovarian neoplasms with emphasis on borderline ovarian tumors: an institutional perspective

Prognostic parameters of luminal A and luminal B intrinsic breast cancer subtypes of Pakistani patients

Contact Info

Product

Resources

About