Molecular Targeting‐Mediated Mild‐Temperature Photothermal Therapy with a Smart Albumin‐Based Nanodrug

Gao, Ge; Jiang, Yao‐Wen; Sun, Wei; Guo, Yuxin; Jia, Hao‐Ran; Yu, Xiaqing; Pan, Guang-Yu; Wu, Fu‐Gen

doi:10.1002/smll.201900501

Cited by 191 publications

(96 citation statements)

References 88 publications

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“…Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), are widely used to treat infections and exhibit a distinct advantage over conventional chemical antimicrobial agents 27 . Considering the complex structure of the eye, a bactericidal strategy of mild temperature photothermal assisted therapy, which remains the antibacterial effect but reduces thermal damage to nearby tissues, is more suitable for endophthalmitis 28 , 29 . PDT, which can produce reactive oxygen species (ROS), also shows antibacterial ability while it can improve the treatment effects and decrease side effects of PTT 30 .…”

Section: Introductionmentioning

confidence: 99%

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Yang¹,

He²,

Qiao³

et al. 2020

Theranostics

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Rationale: Endophthalmitis, which is one of the severest complications of cataract surgeries, can seriously threaten vision and even lead to irreversible blindness owing to its complicated microenvironment, including both local bacterial infection and severe inflammation. It is urgent to develop a comprehensive treatment for both anti-bacterial and anti-inflammatory effects. Methods: Herein, we developed AuAgCu 2 O-bromfenac sodium nanoparticles (AuAgCu 2 O-BS NPs), which was designed to combine anti-bacterial and anti-inflammatory effects for integrated therapy of endophthalmitis after cataract surgery. The AuAgCu 2 O-BS NPs could eradicate methicillin-resistant Staphylococcus aureus (MRSA) bacterial strain relied on their photodynamic effects and the release of metal ions (Ag + and Cu + ) by the hollow AuAgCu 2 O nanostructures mediated mild photothermal effects. The anti-inflammatory drug, bromfenac sodium, released from the nanoparticles were able to significantly reduce the local inflammation of the endophthalmitis and promote tissue rehabilitation. In vivo bacterial elimination and anti-inflammation were confirmed by a postcataract endophthalmitis rabbit model. Results: Excellent antibacterial ability of AuAgCu 2 O-BS NPs was verified both in vitro and in vivo . Ophthalmological clinical observation and pathologic histology analysis showed prominent treatment of inflammatory reaction. Importantly, the mild temperature photothermal effect not only promoted the release of metal ions and bromfenac sodium but also avoided the thermal damage of the surrounding tissues, which was more suitable for the practical application of ophthalmology due to the complex structure of the eyeball. Moreover, superior biocompatibility was approved by the preliminary toxicity investigations, including low cytotoxicity, negligible damage to major organs, and stable intraocular pressure. Conclusions: Our studies of nanosystem provide a promising synergic therapeutic strategy for postcataract endophthalmitis treatment with favorable prognosis and promise in clinical translations.

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Section: Introductionmentioning

confidence: 99%

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Yang¹,

He²,

Qiao³

et al. 2020

Theranostics

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“…In the absence of BSA, the product was agglomerated with large size ( Figure S1, Supporting Information), indicating that BSA plays a key role in promoting 1D nanorods formation. [43][44][45] Typically, atomic force microscopy (AFM) (Figure 1b,c) and transmission electron microscopy (TEM) images (Figure 1d,e) showed that the size of Te-Gd was similar to that of Te without Gd adding ( Figure S2, Supporting Information). The lattice fringes of Te-Gd were measured to be 0.389 and 0.323 nm, respectively (Figure 1f), which were in consistent with the (1 0 0) and (1 0 1) crystal planes of hexagonal Te (JCPDS # 04-0554), respectively, and match well with the result of Figure 1g.…”

Section: Resultsmentioning

confidence: 97%

Engineering Gadolinium‐Integrated Tellurium Nanorods for Theory‐Oriented Photonic Hyperthermia in the NIR‐II Biowindow

Dong

Wen

et al. 2020

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Near‐infrared (NIR) light‐triggered hyperthermia has exhibited promising prospects in oncology therapy due to the unique merits including minimal invasiveness, monitorable, excellent therapeutic effect, and negligible side effects. Especially, the second NIR biowindow (NIR‐II, 1000–1700 nm) with less absorbance and scattering by skin tissue, and deep tissue penetration, has received extensive attention for photonic hyperthermia. Unfortunately, the dissatisfactory photothermal conversion efficiency (PCE) and cumbersome preparation process of photo‐driven heat conversion nanomaterials seriously hamper the future clinical application. To combat the aforementioned challenges, high imaging performance and desired therapeutic outcome 1D nanorods are constructed based on gadolinium‐integrated tellurium nanorods (Te–Gd). In this system, magnetic resonance (MR) imaging and X‐ray computed tomography (CT) imaging‐guided photonic hyperthermia can be easily implemented in cooperation with Te–Gd. Importantly, Te–Gd possesses high PCE (41%) in the NIR‐II biowindow because the transition of the excited electron can easily occur from the valence band (VB) to the conduction band (CB) on (1 0 1) and (1 0 2) crystal planes. Furthermore, the distinctive photostability, high tumor accumulation, as well as low systemic adverse effects of Te–Gd guarantee the potential in the clinic.

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“…Furthermore, we investigated the cell endocytic pathways of HA-IR825-Chol by using 4T1 cells. Chlorpromazine (CPZ) hydrochloride, genistein, 5-(N,Ndimethyl)-amiloride (amiloride), methyl-β-cyclodextrin (MβCD), and 4°C treatment were used to inhibit clathrinmediated, caveolae-mediated, macropinocytosis-dependent, lipid raft-mediated, and energy-dependent pathway, respectively [69]. The flow cytometric results in Fig.…”

Section: Cellular Uptake Behavior and Cytotoxicity Of Ha-ir825-chol Npsmentioning

confidence: 99%

Mitochondrion- and nucleus-acting polymeric nanoagents for chemo-photothermal combination therapy

et al. 2020

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Developing intrinsically mitochondria-targetable nanosystems for subcellular structure-oriented precise cancer therapy is highly desirable. Here, we conjugate the cluster determinant 44 (CD44)-targetable hyaluronic acid (HA) with cholesterol-poly(ethylene glycol) 2k -NH 2 and mitochondria-acting IR825-NH 2 (a cyanine dye) to construct a self-assembled nanostructure (abbreviated as HA-IR825-Chol) for photothermal therapy. The HA-IR825-Chol exhibits improved photostability and desirable photothermal properties, and can rapidly and substantially enter CD44-overexpressed cancer cells and selectively accumulate in the mitochondria of the cells. Upon near-infrared laser irradiation, it can induce severe mitochondrial damage, which causes cytochrome c release and triggers cell apoptosis. Furthermore, we demonstrate the feasibility of loading the chemotherapeutics 10-hydroxycamptothecin (HCPT) into the hydrophobic cores of HA-IR825-Chol NPs for combined chemophotothermal therapy. HCPT encapsulated within HA-IR825-Chol achieves significantly increased cellular uptake and simultaneous mitochondrial and nuclear localization, leading to the release of cytochrome c from mitochondria and upregulation of cleaved caspase-3, both of which contribute to the cell apoptosis/death. In vivo experiments reveal the excellent tumor-targeting ability of HA-IR825-Chol/HCPT, ensuring the efficient tumor eradication by the chemo-photothermal therapy. This work exemplifies the development of an intrinsically mitochondria-targetable nanocarrier for precise subcellular structure-localized drug delivery, and the Chol-mediated rapid and massive endocytosis of the nanoagents may represent a robust strategy for enhancing the efficacies of nanomedicines.

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Molecular Targeting‐Mediated Mild‐Temperature Photothermal Therapy with a Smart Albumin‐Based Nanodrug

Cited by 191 publications

References 88 publications

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Engineering Gadolinium‐Integrated Tellurium Nanorods for Theory‐Oriented Photonic Hyperthermia in the NIR‐II Biowindow

Mitochondrion- and nucleus-acting polymeric nanoagents for chemo-photothermal combination therapy

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