Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise

Abstract

Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.

Influence of low‐dose aspirin, resistance exercise, and sex on human skeletal muscle PGE2/COX pathway activity

“…Interestingly, similar effectiveness of low‐dose aspirin compared with doses up to eight times higher has been shown in nonskeletal muscle tissue (Sample et al, 2002). The current results also extend our previous findings on aerobic exercise (Fountain et al, 2020) to include resistance exercise and thus encompass the two most common forms of exercise recommended to the general population for skeletal muscle and overall health (Piercy et al, 2018; Sanford et al, 2020). Finally, as data start to build on aspirin and skeletal muscle, it appears that aspirin has a sex‐specific effect on the PGE 2 /COX pathway at the skeletal muscle tissue level.…”

“…Subject characteristics of the individuals (4 M/2 W) included in this investigation are presented in Table 1. Subjects also completed resistance exercise familiarization prior to an acute resistance exercise trial with muscle biopsies (Fountain et al, 2020; Sanford et al, 2020). Specific pretrial controls were in place for COX inhibitor consumption, diet, physical activity, and menstrual cycle timing for the women.…”

“…Each trial consisted of a supine rest period of at least 30 minutes prior to a baseline muscle biopsy, a resistance exercise bout followed by a 3.5‐hour supine rest period, and a postexercise muscle biopsy (Figure 1). The postexercise timepoint was chosen because of the increased metabolic and molecular activity related to exercise adaptation (Sanford et al, 2020) and the increased COX activity and PG production (Carroll et al, 2013; Trappe & Liu, 2013; Vella et al, 2019). In addition, this timepoint coincided with our previous study on aspirin and aerobic exercise (Fountain et al, 2020).…”

Precision clinical trials: a framework for getting to precision medicine for neurobehavioural disorders

“…One answer is that, in spite of the existence of individual differences in response, 66 little neurobehavioural research has examined treatmentinteractive effects as predictors of ultimate response; this stands in contrast to robust and even transformative work from other fields (such as oncology) with treatment-targeted enrichment. [67][68][69] As well, we have an increasing ability to precisely measure acute brain and behavioural changes using emerging techniques such as precision brain-mapping or digit al phenotyping as described later. A second source of resistance is concern about the notion of excluding participants who need treatment but who are unlikely to respond.…”

The Role of HDL and HDL Mimetic Peptides as Potential Therapeutics for Alzheimer’s Disease

“…Although it is well known that exercise and certain diets elevate HDL levels and improve HDL functionality [228,229], the contribution of HDL to the reduced risk of AD in those studies is not clear. Notably, among many lifestyle intervention projects, the National Institutes of Health recently funded the largest exercise research program of its kind, Molecular Transducers of Physical Activity Consortium (MoTrPAC), to study the impact of physical exercise at the molecular level [230]. The results from MoTrPAC are expected to unravel the molecular basis of the health benefits of exercise throughout the body, including metabolism, immune responses, and cardiovascular and brain function, which may provide novel insights into the role of HDL in health and diseases.…”