Molecular Weight Dependence of the Pharmacokinetic of Hydroxypropyl Methylcellulose in the Vitreous

Fernández‐Vigo, José Ángel; Sabugal, J. F.; Rey, André; Concheiro, Angel; Martinez, R.

doi:10.1089/jop.1990.6.137

Cited by 16 publications

(8 citation statements)

References 3 publications

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“…Different experimental polymers have been studied, varying the molecular weight [96]. Researchers have tried to reduce intraocular degradation time, but as of today it is not yet available as a long-term vitreal substitute [97].…”

Section: Experimental Substitutesmentioning

confidence: 99%

Vitreous Substitutes: The Present and the Future

Donati

Caprani

Airaghi

et al. 2014

BioMed Research International

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Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties.

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Section: Experimental Substitutesmentioning

confidence: 99%

Vitreous Substitutes: The Present and the Future

Donati

Caprani

Airaghi

et al. 2014

BioMed Research International

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“…Fernandez-Vigo et al injected a solution of hydroxypropyl methylcellulose (HPMC) (viscosity ~6000 cSt, M w = 86 kDa) in rabbits' eyes [177]: HPMC was completely eliminated from the vitreous cavity within 10 weeks after implantation and, therefore, the authors concluded in this first study that HPMC solutions are useful neither as a long-term vitreous substitute nor for sealing retinal holes in RRD due to the lack of tamponade effect. However, the excellent biocompatibility of HPMC was encouraging and the authors carried out another animal study in which they demonstrated that the residence time of HPMC in the vitreous cavity could be controlled by varying its molecular weight [178].…”

Section: Hydroxypropyl Methylcellulosementioning

confidence: 99%

“…Also, three other materials, HPMC [177,178], the cross-linked gelatins recently tested by Lai [152], and the gellan gum/hyaluronic acid gel proposed by Suri et al [159], exhibit interesting properties, but seem only useful for short-term vitreous substitution.…”

Section: Towards An Ideal Vitreous Substitutementioning

confidence: 99%

The Use of Polymers in the Treatment of Retinal Detachment: Current Trends and Future Perspectives

Baino

2010

Polymers

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Abstract:Procedures for the treatment of retinal detachment and related conditions have been successfully improved upon in recent years thanks to the advent of new therapies and biomaterials. This review, after giving an overview on eye structure and function, focuses on the treatment of retinal detachment and examines the role and features of the materials used in vitreoretinal surgery, emphasizing scleral buckling and short-term/long-term vitreous tamponade. Specifically, the limitations of existing biomaterials are underlined, based on experimental studies and with particular reference to cells/material interactions. Finally, current and future trends of biomaterials' research in the field of vitreoretinal surgery are considered and discussed.

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“…Whereas multiple synthetic polymers that have been employed as potential vitreous substitute, such as poly(vinyl alcohol) and poly(glyceryl methacrylate), are usually with tunable mechanical properties and prolonged stability, these materials do not inherently interact with proteins or cells, leading to inferior biocompatibility and biodegradability . By contrast, natural polymers that have been tested as vitreous substitute, such as HA, collagen and cellulose derivatives, have the advantage of being nontoxic and biodegradable. However, these polymers are usually with weak mechanical strength and thus would be easily eliminated from the vitreous cavity shortly after implantation since the vitreous cavity is a semi‐open environment with constant fluid flows .…”

Section: Introductionmentioning

confidence: 99%

The feasibility study of an in situ marine polysaccharide‐based hydrogel as the vitreous substitute

Jiang

Peng

Yang³

et al. 2018

J Biomedical Materials Res

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Although various biopolymers and synthetic compounds have been proposed and tested as the vitreous substitutes, no ideal material has been identified yet. In the present study, we developed an in situ-formed hydrogel by crosslinking hydroxypropyl chitosan with alginate dialdehyde. Physical properties of the hydrogel were studied and the cytotoxicity was evaluated using L929 fibroblasts, rabbit corneal endothelial cells and retinal pigment epithelial cells. In a preliminary in vivo study, the hydrogel was employed as vitreous substitute after vitrectomy surgery on rabbits and multiple parameters indicating biosafety and biocompatibility were measured and analyzed postoperatively. Our results showed that the refractive index, transmittance, pH value and density of the hydrogel were similar to those of human vitreous. Cytotoxicity tests demonstrated the hydrogel to be nontoxic to all of the three cell lines selected. Using the rabbit model, we showed that the hydrogel could form in situ and postoperative analysis of slit-lamp observation, intraocular pressure, corneal endothelium examination, B-scan ultrasound and fundus photography showed no significant adverse reactions in the operated eyes during the 90-day follow-up. However, electroretinogram and histopathological examinations indicated minor vision decline and decrease of the densities of cones and rods in the operated rabbit eyes. Collectively, our study suggested that the in situ-formed hydrogel could potentially be used as a vitreous substitute, with its long-term safety and efficacy to be further assessed. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1997-2006, 2018.

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Molecular Weight Dependence of the Pharmacokinetic of Hydroxypropyl Methylcellulose in the Vitreous

Cited by 16 publications

References 3 publications

Vitreous Substitutes: The Present and the Future

Vitreous Substitutes: The Present and the Future

The Use of Polymers in the Treatment of Retinal Detachment: Current Trends and Future Perspectives

The feasibility study of an in situ marine polysaccharide‐based hydrogel as the vitreous substitute

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