Molecular weights by gel permeation chromatography: Unperturbed dimensions calibration for polyisoprene

Dawkins, J. V.; Denyer, R. L.; Maddock, John

doi:10.1016/0032-3861(69)90024-x

Cited by 21 publications

(1 citation statement)

References 12 publications

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“…Most of the commercially available bioabsorbable synthetic polymers have ester linkages that get hydrolysed in the presence of moisture, under both in vitro and in vivo environments. The affinity towards moisture is expressed by the hydrophilic hydroxyl end groups facilitating the phenomenon of hydrolysis 6 . The carboxyl groups generated by hydrolysis further promote hydrolysis of ester bonds resulting in fast weight and strength loss as a result of which the synthetic bioabsorbable polymer becomes incapable of holding the wound edges during healing 7 .…”

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Controlled Hydrolytic Degradation of Polyglycolide–Caprolactone-Based Bioabsorbable Copolymer

Singh

Tyagi

2017

Current Science

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Polyglycolide-caprolactone (PGCL)-based copolymer was synthesized from glycolide and caprolactone by ring opening polymerization in the presence of stannous octoate catalyst and diethylene glycol initiator. The effects of prepolymerization time, monomer ratio, monomer-to-catalyst and monomer-to-initiator ratios on per cent weight conversion were optimized. The end-capped copolymer was synthesized to make absorbable sutures having controlled bioabsorbability at different pH levels. It was observed that endcapped absorbable copolymer was more stable at pH 10.0 compared to uncapped absorbable material. End-capped copolymer also retained higher tensile strength compared to uncapped copolymer after 21 days. This phenomenon of controlled hydrolytic degradation of PGCL-based bioabsorbable polymer having terminal group end-capping can be attributed to less availability of hydrophilic end groups facilitating hydrolytic degradation of polymers.

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confidence: 99%