Molecularly imprinted polymer as SPE sorbent for selective extraction of melamine in dairy products

Yang, Huang‐Hao; Zhou, Wen-Hui; Guo, Xiuchun; Chen, Fa-Rong; Zhao, Hengqiang; Liming, Lin; Wang, Xiaoru

doi:10.1016/j.talanta.2009.07.067

Cited by 101 publications

(63 citation statements)

References 11 publications

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“…It is due to the fact that MIP exhibits a higher adsorption capacity of melamine compared to NIP. The weak adsorption of melamine template on NIP is due to non-specific interaction with the polymer matrix [10]. …”

Section: Ph Studymentioning

confidence: 99%

“…In the most common preparation process, monomers form a complex with a template through covalent or non-colvent interactions and are then joined by using a cross-linking agent. After the removal of the template by chemical reaction or extraction, binding sites are exposed which are complementary to the template in size, shape, and position of the functional groups, and consequently allow its selective uptake [10].…”

Section: Introductionmentioning

confidence: 99%

“…The most widely used technique for preparing MIPs is non-covalent imprinting [10]. In this process, the complex of template and functional monomer is formed in situ by non-covalent interactions, such as hydrogen bonding, electrostatic forces, van der Waals forces, or hydrophobic interactions.…”

Section: Introductionmentioning

confidence: 99%

“…The MIP is prepared by mixing the functional monomer, template, cross-linker, and initiator in a proper solvent [11]. There are several advantages of this technique including easy preparation of the template monomer complex, easy removal of the templates from the polymers, fast binding of templates to MIPs, and its potential application to a wide range of target molecules [10,12]. However, to maximize the formation of the labile complex of template and monomer, the polymerization conditions must be carefully chosen to minimize non-specific binding sites.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Molecularly Imprinted Polymer as SPE Sorbent for Melamine Isolation

et al. 2013

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Abstract:In this paper, a separation procedure combining molecularly imprinted-solid phase extraction (MI-SPE) was developed for the isolation of melamine. The molecularly imprinted polymer (MIP) was prepared using precipitation polymerization method where melamine as template, 9-vinylcarbazole as functional monomer, ethtylene glycol dimethacrylate as a cross-linker and benzoyl peroxide as initiator. An off-line MI-SPE method followed by ultra-performance liquid chromatography detection of melamine was established. MIP showed a better affinity toward melamine compared to non imprinted polymer (NIP) with a maximum binding capacity of 53.01 mg/g MIP. Based on the correlation coefficients, the kinetic study indicated that the adsorption of melamine by MIP fit a pseudo-second order model. From isotherm study, adsorption of melamine by MIP increased when the concentration of melamine increased and followed a Freundlich isotherm model, which indicates the sorption can be described by multilayer sorption. The interference study proved that MIP has better binding capacity towards melamine if compared to NIP due to specific sites of melamine occurred in MIP particles.

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Section: Ph Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Molecularly Imprinted Polymer as SPE Sorbent for Melamine Isolation

et al. 2013

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“…Melamina é uma triazina (Figura 5.1) amplamente utilizada na produção de plásticos, resinas e adesivos em razão de conferir a estes produtos alta tolerância térmica [110,111]. Ela também tem sido utilizada na adulteração de alimentos, especialmente de leite, devido o seu alto teor de nitrogênio, o qual corresponde a 66,7 % da massa total e também ao seu baixo custo [106].…”

Section: Determinação De Melamina Em Leiteunclassified

Estratégias para aumento de sensibilidade e seletividade de separações cromatográficas em sistemas de análises em fluxo

Batista¹

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Synthesis of a Molecularly Imprinted Polymer for Melamine Analysis in Milk by HPLC with Diode Array Detection

2015

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Abbreviations:AIBN -azobisisobutyronitrile; CL -cross-linker; EDMA -ethylene glycol dimethacrylate; Kd -dissociation constant; MAA -methacrylic acid; MIDE -molecularly imprinted dispersive extraction; MIP -molecularly imprinted polymer; NIP -nonimprinted polymer; PVA -polyvinyl alcohol; Qmax -maximum binding concentration; Rrecovery; T -template. Keywords:Molecularly imprinted polymer (MIP), matrix effect, molecularly imprinted dispersive extraction coupled with high-performance liquid chromatography. 2 AbstractA molecularly imprinted polymer for melamine was prepared by suspension polymerization, using melamine as template, methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker.The optimal template/monomer and monomer/cross-linker ratios were obtained, being defined as 1/15 and 1/12, respectively. The template removal was performed by Soxhlet extraction with methanol containing 10% of acetic acid, in two cycles of 24 h each. Under optimal conditions the imprinted polymer was used as a dispersive extraction sorbent to extract melamine from different milk samples, before HPLC-DAD analysis.The validated method presented a limit of detection of 0.6 mg/kg. From the analysis of six different milks, melamine was detected in two of the considered samples in a maximum concentration of 9.3 ± 0.3 mg/kg.3

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Molecularly imprinted polymer as SPE sorbent for selective extraction of melamine in dairy products

Cited by 101 publications

References 11 publications

Preparation and Characterization of Molecularly Imprinted Polymer as SPE Sorbent for Melamine Isolation

Preparation and Characterization of Molecularly Imprinted Polymer as SPE Sorbent for Melamine Isolation

Estratégias para aumento de sensibilidade e seletividade de separações cromatográficas em sistemas de análises em fluxo

Synthesis of a Molecularly Imprinted Polymer for Melamine Analysis in Milk by HPLC with Diode Array Detection

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