Molecularly-imprinted polymer-base bulk optode for the determination of ivabradine hydrochloride in Procoralan®

Abstract

IVH may be administered orally twice per day for treating heart failure, sinus rhythm, heart-related chest pain and angina pectoris; its overdose may cause problems as blurred vision, uncontrolled blood pressure, prolonged bradycardia, and others.

Non-Enzymatic Phenylboronic Acid-Based Optode Membrane for Glucose Monitoring in Serums of Diabetic Patients and in the Culture Medium of Human Embryos

“…Regeneration was tested by soaking optode 3 in 0.1 M NaOH to deprotonate the chromoionophore ETH 7075. After soaking, the calibration curve was recorded, followed by soaking in buffer solution [ 49 ]. The regeneration step can only be performed with buffer solution but it takes several hours.…”

“…The regeneration step can only be performed with buffer solution but it takes several hours. However, a strong base shortens this time to a few minutes, which is sufficient to recover about ≥ 95% of the signal [ 49 ]. This time reduction is beneficial to minimize the dissolution of the optode in the measurement or soaking solutions and to shorten the measurement time so that it is suitable for routine analysis and reuse of the optode.…”

Ionophore-modified polyaniline-based optode for the determination of hydrogen sulfite levels in beverages, wastewater, and soil

“…For better performance of sensor 4, soaking in buffer solution may improve response to more than 95% of its original reading. 46…”

Biodegradable and Sustainable Synthetic Antibodies—A Perspective

“…MIPs are classically produced via polymerization in bulk, where a high concentration of monomers in a suitable solvent is polymerized extensively until a monolith is obtained [ 23 , 44 , 45 , 46 , 47 , 48 , 49 ]. Historically, these monoliths were then processed by grinding and fractionated via sieving to collect a regularly-sized powder which could then be exploited for further applications.…”

“…Historically, these monoliths were then processed by grinding and fractionated via sieving to collect a regularly-sized powder which could then be exploited for further applications. This method is indeed still used, especially when quick and easy tests might be required (e.g., to assess whether a polymerization mixture would be suitable for a certain target) [ 46 , 49 ]. Nonetheless, it is extremely poorly compatible with the generation of MIP NPs.…”