In this study, to enhance selective and sensitive salbutamol detection based on the carbon plate electrode was modified with the novel-molecularly imprinted polymer (MIP) combined with reduced graphene oxide (RGO). RGO/MIP was prepared by polymerization containing methacrylic acid as a monomer and salbutamol as a template. The modified electrode was observed surface morphology by FE-SEM, tested performance by an electrochemical technique which was investigated both cyclic voltammetry (CV) and amperometry (AMP) mode. The performance of the modified electrode was compared between MIP and RGO/MIP electrode, which the RGO/MIP electrode was demonstrated at 4.16 nA/ppm of sensitivity higher than 0.91 nA/ppm of MIP electrode. There was a limit of detection (LOD) of the RGO/MIP electrode at 0.83 ppm lower than the MIP electrode. Moreover, RGO/MIP electrode was dynamic ranges from 1 to 1000 ppm, exhibited stability, repeatability, fast response, and high selectivity for salbutamol detection.