Molecularly imprinted polymers for food applications: A review

Villa, Cristian C.; Sánchez, Leidy T.; Valencia, Germán Ayala; Ahmed, Shakeel; Gutiérrez, Tomy J.

doi:10.1016/j.tifs.2021.03.003

Cited by 116 publications

(43 citation statements)

References 223 publications

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“…After isolating the polymer, the template is removed [ 1 ]. This results in specific binding sites that allow for the specific binding that differentiates imprinted polymers from non-imprinted resins [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Common Syntheses For Imprinting Polymerizationsmentioning

confidence: 99%

“…At this point, MIPs are used in many different applications. Broadly, they can be grouped into two categories: Detection and sensing for a variety of compounds, from contaminants to proteins in cells [6][7][8][9][10][11][12][13][14][15][16][17][18] and extraction and purifications of compounds from environmental and biological samples [19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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A Note about Crosslinking Density in Imprinting Polymerization

Mueller

2021

Molecules

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Imprinting polymerization is an exciting technique since it leads to specific binding sites, which are the basis of a variety of applications, such as sensors, detectors, and catalysts. The specific binding sites are created using templates and then fixing the structure of the binding site with crosslinking. The literature review of imprinting polymerizations shows that the crosslinking density governs the physical properties of the resulting molecularly imprinted polymer (MIP). It is also a factor governing the capacity and the selectivity of MIPs. Reviewing polymer science data and theory, the crosslinking density commonly used in MIP synthesis is unusually high. The data reviewed here suggest that more research is needed to determine the optimal crosslinking density for MIPs.

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Section: Common Syntheses For Imprinting Polymerizationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Note about Crosslinking Density in Imprinting Polymerization

Mueller

2021

Molecules

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“…[13,14] The properties of this receptor can be controlled to produce materials with good mechanical properties, excellent selectivity, and good thermal and chemical stability. [15] Therefore, they can be used for many advanced applications [16] such as food applications and detection of contaminants in food, [17,18] biological applications, [19] solid phase extraction, [20] environmental applications [21] drug delivery, [22] sensing applications, [23] membrane separation, [24] and so on.…”

Section: Introductionmentioning

confidence: 99%

Molecular imprinted polymer for tramadol: Absorption and drug release studies

Morsi

Youssef

Kamal

et al. 2022

Polymer Engineering & Sci

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Smart polymeric matrices based on 2-vinyl pyridine (2-VPY) and three different crosslinkers: ethylene glycol dimethacrylate (EGDMA), divinylbenzene (DVB), and trimethylolpropane trimethacrylate (TMPTMA) were prepared either by the imprinting technique of the tramadol molecule or conventionally by the free radical polymerization process. The polymers were used as sorbent materials for tramadol from its solutions. The polymers prepared by the imprinting technique demonstrated superior absorption of tramadol molecules than those prepared by the conventional method. The two sorbent materials constructed from TMPTMA, regardless of the method, achieved the highest absorption capacity compared with those prepared from EGDMA or DVB. It was found that loaded imprinted polymer released more tramadol than loaded nonimprinted polymer in all media. In the acidic medium, the protonation of the nitrogen atom in the pyridine ring ionized the chains and expanded the loaded pores leading to the rapid release over the neutral and alkaline media. Additionally, the isothermal studies of MIP3 and NIP3 were extremely fitted to Freundlich adsorption and the (D-R) isotherm, respectively, while the kinetic studies of both sorbents were fitted to the pseudo-second-order model.

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“…The resulting monolith can be crushed and the template extracted, yielding a powder with a crude morphology [ 33 ]. This protocol is robust and can enable the rapid testing of polymer formulations when attempting to design an MIP [ 34 ]. Although the bulk imprinting approach is a tried-and-tested approach of successfully producing MIPs, the methodology has been surpassed by more elegant approaches that enable more homogenous morphologies and particles sizes [ 35 , 36 , 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Colorimetric Sensing of Amoxicillin Facilitated by Molecularly Imprinted Polymers

et al. 2021

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The scope of the presented research orientates itself towards the development of a Molecularly Imprinted Polymer (MIP)-based dye displacement assay for the colorimetric detection of the antibiotic amoxicillin in aqueous medium. With this in mind, the initial development of an MIP capable of such a task sets focus on monolithic bulk polymerization to assess monomer/crosslinker combinations that have potential towards the binding of amoxicillin. The best performing composition (based on specificity and binding capacity) is utilized in the synthesis of MIP particles by emulsion polymerization, yielding particles that prove to be more homogenous in size and morphology compared to that of the crushed monolithic MIP, which is an essential trait when it comes to the accuracy of the resulting assay. The specificity and selectivity of the emulsion MIP proceeds to be highlighted, demonstrating a higher affinity towards amoxicillin compared to other compounds of the aminopenicillin class (ampicillin and cloxacillin). Conversion of the polymeric receptor is then undertaken, identifying a suitable dye for the displacement assay by means of binding experiments with malachite green, crystal violet, and mordant orange. Once identified, the optimal dye is then loaded onto the synthetic receptor, and the displaceability of the dye deduced by means of a dose response experiment. Alongside the sensitivity, the selectivity of the assay is scrutinized against cloxacillin and ampicillin. Yielding a dye displacement assay that can be used (semi-)quantitatively in a rapid manner.

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Molecularly imprinted polymers for food applications: A review

Cited by 116 publications

References 223 publications

A Note about Crosslinking Density in Imprinting Polymerization

A Note about Crosslinking Density in Imprinting Polymerization

Molecular imprinted polymer for tramadol: Absorption and drug release studies

Colorimetric Sensing of Amoxicillin Facilitated by Molecularly Imprinted Polymers

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