Molecularly imprinted polymers for selective solid-phase extraction of phospholipids from human milk samples

Ten-Doménech, Isabel; Martínez-Pérez-Cejuela, Héctor; Lerma‐García, María Jesús; Simó‐Alfonso, Ernesto Francisco; Herrero‐Martínez, José Manuel

doi:10.1007/s00604-017-2345-6

Cited by 14 publications

(7 citation statements)

References 36 publications

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“…being SPE the commonly used technique [5,6,[39][40][41]. Regarding recoveries, our values were similar to those reported in literature [5,6,43,39,41], which demonstrates the suitability of the procedure. Concerning LODs and LOQs, our SPE protocol gave comparable values to those reported using ELSD [6], but higher than those obtained using more sophisticated techniques, such as MS [43,39].…”

Section: Extraction and Analysis Of Pls From Lipid Extracts Of Milksupporting

confidence: 89%

“…Concerning LODs and LOQs, our SPE protocol gave comparable values to those reported using ELSD [6], but higher than those obtained using more sophisticated techniques, such as MS [43,39]. In addition, the amount of sorbent in the SPE cartridges for PLs analysis ranges from 25 mg for home-made cartridges [41] to 1000 g for commercial cartridges [5,45].…”

Section: Extraction and Analysis Of Pls From Lipid Extracts Of Milkmentioning

confidence: 53%

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Polymer-based materials modified with magnetite nanoparticles for enrichment of phospholipids

Ten-Doménech

Martínez-Pérez-Cejuela

Simó‐Alfonso

et al. 2018

Talanta

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A polymeric material modified with magnetic nanoparticles (MNPs) has been synthesized and evaluated as sorbent both for solid-phase extraction (SPE) and dispersive magnetic solid-phase extraction (MSPE) of phospholipids (PLs) in human milk samples. The synthesized sorbent was characterized by scanning electron microscopy and its iron content was also determined. Several experimental variables that affect the extraction performance (e.g. loading solvent, breakthrough volume and loading capacity) were investigated and a comparison between conventional SPE and MSPE modalities was done. The proposed method was satisfactorily applied to the analysis of PLs in human milk fat extracts in different lactation stages and the extracted PLs were determined by means of hydrophilic interaction liquid chromatography using evaporative light scattering detection.

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Section: Extraction and Analysis Of Pls From Lipid Extracts Of Milksupporting

confidence: 89%

Section: Extraction and Analysis Of Pls From Lipid Extracts Of Milkmentioning

confidence: 53%

Polymer-based materials modified with magnetite nanoparticles for enrichment of phospholipids

Ten-Doménech

Martínez-Pérez-Cejuela

Simó‐Alfonso

et al. 2018

Talanta

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“…These results are in agreement with another reported lactate-based MIP, where a MIP designed for the selective solid-phase extraction of phospholipids from human milk signified a reuse capability of up to 20 and 6 times in the case of phospholipids standards and human milk fat samples. 54 The presented experimental values are summarized in Table 2.…”

Section: Synthesis and Characterization Of Mip And Nipmentioning

confidence: 99%

Fabrication of a Lactate-Specific Molecularly Imprinted Polymer toward Disease Detection

Mustafa

Leese

2023

ACS Omega

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The development of sensitive and selective robust sensor materials for targeted biomarker detection aims to contribute to self-health monitoring and management. Molecularly imprinted polymeric (MIP) materials can perform as biomimetic recognition elements via tailored routes of synthesis for specific target analyte extraction and/or detection. In this work, a sensitiveand selective-lactate MIP has been developed utilizing methacrylic acid and ethylene glycol dimethacrylate as the functional monomer and cross-linker, respectively. The sensitivity of the assynthesized imprinted species was evaluated by determining the target analyte retention, imprinting factor, and selectivity adsorption of up to 63.5%, 6.86, and 0.82, respectively. MIP selectivity elucidated the imprinting mechanism between the functional monomers and target analyte lactate, further experimentally evidenced by using structurally competitive analytes malic acid and sodium 2-hydroxybutyrate, where retentions of 22.6 and 25.2%, respectively, were observed. Understanding the specific intermolecular mechanisms of both the template analyte and structural interferents with the MIP enables experimentalists to make informed decisions regarding monomer-target and porogen selections and possible sites of interaction for improved molecular imprinting. This imprinting system highlights the potential to be further developed into artificial receptor sensor materials for the detection of disease.

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“…The key to success lies in their simple preparation, high permeability, tunable properties, and easily available surface chemistries. The polymerization reaction to synthesize these materials can be initiated by different strategies, being thermal [4,5] and photoinduced [6,7] modes the most usual ones. Within photopolymerization modes, UV irradiation has been the most common way, although another type of electromagnetic radiation has also been used [8].…”

Section: Introductionmentioning

confidence: 99%

Influence of photo-initiators in the preparation of methacrylate monoliths into poly(ethylene-co-tetrafluoroethylene) tubing for microbore HPLC

Catalá-Icardo

Torres-Cartas

Simó‐Alfonso

et al. 2020

Analytica Chimica Acta

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Molecularly imprinted polymers for selective solid-phase extraction of phospholipids from human milk samples

Cited by 14 publications

References 36 publications

Polymer-based materials modified with magnetite nanoparticles for enrichment of phospholipids

Polymer-based materials modified with magnetite nanoparticles for enrichment of phospholipids

Fabrication of a Lactate-Specific Molecularly Imprinted Polymer toward Disease Detection

Influence of photo-initiators in the preparation of methacrylate monoliths into poly(ethylene-co-tetrafluoroethylene) tubing for microbore HPLC

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