Moléculas de adhesión endoteliales ICAM-1, VCAM-1 y E-selectina en pacientes con síndrome coronario agudo

Macías, Consuelo; Villaescusa, Rinaldo; Valle, Lázaro del; Boffil, Víctor; Cordero, Girelda; Hernández, Alberto; Hernández, P; Ballester, José Manuel

doi:10.1016/s0300-8932(03)76837-7

Cited by 27 publications

(13 citation statements)

References 31 publications

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“…These results are consistent with a previous report describing raised sE-selectin levels in patients with ACS [66]. According to ACS type, Macías et al [67] reported increased levels in patients with UA at admission and ten days later suggesting that sE-selectin could be a marker for unstable angina and might be useful in the differential diagnosis of myocardial infarction. To address this issue, we made soluble level comparisons by ACS type.…”

Section: Resultssupporting

confidence: 92%

Assessment of theE-Selectinrs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels

Sandoval-Pinto

Padilla-Gutiérrez

Valdés-Alvarado

et al. 2014

Mediators of Inflammation

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Introduction. The acute coronary syndrome (ACS) is a complex disease where genetic and environmental factors are involved. E-selectin gene is a candidate for ACS progression due to its contribution in the inflammatory process and endothelial function. The rs5361 (561A>C) polymorphism in the E-selectin gene has been linked to changes in gene expression, affinity for its receptor, and plasmatic levels; therefore it is associated with an increased risk of cardiovascular disease. The aim of this study was to determine the association of the rs5361 polymorphism with ACS and to measure serum levels of soluble E-selectin (sE-selectin). Materials and Methods. 283 ACS patients and 205 healthy subjects (HS) from Western Mexico were included. The polymerase chain reaction-restriction fragment length polymorphism was used to determine the rs5361 polymorphism. The sE-selectin levels were measured by enzyme-linked immunosorbent assay. Results. Neither genotype nor allele frequencies of the rs5361 polymorphism showed statistical differences between groups. The sE-selectin levels were significantly higher in ACS patients compared to HS (54.58 versus 40.41 ng/ml, P = 0.02). The C allele had no effect on sE-selectin levels. Conclusions. The rs5361 E-selectin gene polymorphism is not a susceptibility marker for ACS in Western Mexico population. However, sE-selectin may be a biological marker of ACS.

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Section: Resultssupporting

confidence: 92%

Assessment of theE-Selectinrs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels

Sandoval-Pinto

Padilla-Gutiérrez

Valdés-Alvarado

et al. 2014

Mediators of Inflammation

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“…Following AMI, activated endothelium within the infarct region drives the expression of transmembrane adhesion molecules that mediate leukocyte-endothelium interactions to orchestrate regional immune responses [21, 22]. These damage-associated adhesion molecules serve as primary “loading-docks” for cell anchorage and their limited and transient post-AMI presence may be correlated to the limited retention of infused cells.…”

Section: Introductionmentioning

confidence: 99%

Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells

Uitterdijk¹,

Groenendijk²,

Gorsse-Bakker³

et al. 2017

PLoS ONE

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BackgroundIntracoronary infusion of autologous bone marrow-derived mononuclear cells (BMMNC), after acute myocardial infarction (AMI), has been shown to improve myocardial function. However, therapeutic efficacy is limited, possibly because cell retention rates are low, suggesting that optimization of cell retention might increase therapeutic efficacy. Since retention of injected BMMNC is observed only within infarcted, but not remote, myocardium, we hypothesized that adhesion molecules on activated endothelium following reperfusion are essential. Consequently, we investigated the role of vascular cell adhesion molecule 1 (VCAM-1) in BMMNC retention in swine undergoing reperfused AMI produced by 120 min of percutaneous left circumflex coronary occlusion.Methods and resultsVCAM-1 expression in the infarct and remote region was quantified at 1, 3, 7, 14, and 35 days, post-reperfusion (n≥6 swine per group). Since expression levels were significantly higher at 3 days (2.41±0.62%) than at 7 days (0.98±0.28%; p<0.05), we compared the degree of cell retention at those time points in a follow-up study, in which an average of 43·106 autologous BMMNCs were infused intracoronary at 3, or 7 days, post-reperfusion (n = 6 swine per group) and retention was histologically quantified one hour after intracoronary infusion of autologous BMMNCs. Although VCAM-1 expression correlated with retention of BMMNC within each time point, overall BMMNC retention was similar at day 3 and day 7 (2.3±1.3% vs. 3.1±1.4%, p = 0.72). This was not due to the composition of infused bone marrow cell fractions (analyzed with flow cytometry; n = 5 per group), as cell composition of the infused BMMNC fractions was similar.ConclusionThese findings suggest that VCAM-1 expression influences to a small degree, but is not the principal determinant of, BMMNC retention.

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“…N.S. indicates non-significant expression of the SREBP1 gene, which contains the LXRα response elements in its promoter (Ma et al, 2008). Moreover, antiinflammatory LXR signalling has been shown to suppress the expression of proinflammatory genes, including MCP-1 and RANTES (Bensinger & Tontonoz, 2008).…”

Section: Discussionmentioning

confidence: 99%

A chalcone derivative, 1m‐6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation‐induced endothelial dysfunction

Chen

Tsai

Tsao

et al. 2020

British J Pharmacology

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Background and Purpose: Atherosclerosis, resulting from lipid dysregulation and vascular inflammation, causes atherosclerotic cardiovascular disease (ASCVD), which contributes to morbidity and mortality worldwide. Chalcone and its derivatives possess beneficial properties, including anti-inflammatory, antioxidant and antitumour activity with unknown cardioprotective effects. We aimed to develop an effective chalcone derivative with antiatherogenic potential. Experimental Approach: Human THP-1 cells and HUVECs were used as in vitro models. Western blots and real-time PCRs were performed to quantify protein, mRNA and miRNA expressions. The cholesterol efflux capacity was assayed by 3 H labelling of cholesterol. LDL receptor knockout (Ldlr −/−) mice fed a high-fat diet were used as an in vivo atherogenesis model. Haematoxylin and eosin and oil red O staining were used to analyse plaque formation.

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Moléculas de adhesión endoteliales ICAM-1, VCAM-1 y E-selectina en pacientes con síndrome coronario agudo

Cited by 27 publications

References 31 publications

Assessment of theE-Selectinrs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels

Assessment of theE-Selectinrs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels

Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells

A chalcone derivative, 1m‐6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation‐induced endothelial dysfunction

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