Molekulare, komponenten-basierte Diagnostik in der HNO-ärztlichen Allergologie

Abstract

Molecular component-resolved diagnostics (CRD) are, in addition to its research applications, being increasingly used in daily allergological routine. CRD offers improved diagnostic accuracy via a better understanding of the underlying allergen causing symptoms and helps to distinguish between true sensitization and cross reactions in polysensitized patients, thereby providing an approach for individual personalized therapy. Particularly in food allergies and anaphylaxis, CRD can stratify risks for the recurrence of reactions and their severity. The education and extended vocational training of clinical allergologists has to keep pace with the tremendous increase of knowledge in the field of molecular allergology.

Biologicals in der Rhinologie – Individualisierte Konzepte der Zukunft

“…Also for diagnosis of anaphylaxis or exclusion of sensitization against alpha-GAL before application of humanized antibodies such as cetuximab, the component-based diagnostics are essential. The EAACI established an application guideline 246 , a more compact version focused on otolaryngology has recently been published also for aeroallergens 247 .…”

“…B. Cetuximab ist die komponentenbasierte Diagnostik essentiell. Die EAACI hat einen Anwendungsleitfaden erstellt 246 , eine kompaktere auf die HNO fokussierte Version ist auch für Aeroallergene kürzlich publiziert worden 247 .…”