Molluscan ligand-gated ion-channel receptors

Darlison, Mark G.; Hutton, Michael; Harvey, Robert J.

doi:10.1007/978-3-0348-7265-2_3

Cited by 10 publications

(4 citation statements)

References 64 publications

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“…It is well known that taurine is an agonist of GABA A and glycine receptors, activation of which can counterbalance the neuronal excitability (Herbison and Moenter, 2011;Komm et al, 2014;Kilb and Fukuda, 2017;Ochoa-de la Paz et al, 2019). Thus, taurine may reduce cell excitability potentially via GABA A receptors that are expressed in L. stagnalis central neurons (Harvey et al, 1991;Darlison et al, 1993). Despite the unknown mechanism, our studies, together with others, clearly indicate that taurine acts as an active neuromodulator that is involved in regulating neuronal membrane excitability.…”

Section: Discussionsupporting

confidence: 55%

“…Thus, taurine may reduce cell excitability potentially via GABA A receptors that are expressed in L . stagnalis central neurons (Harvey et al, 1991 ; Darlison et al, 1993 ). Despite the unknown mechanism, our studies, together with others, clearly indicate that taurine acts as an active neuromodulator that is involved in regulating neuronal membrane excitability.…”

Section: Discussionmentioning

confidence: 99%

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Taurine Promotes Neurite Outgrowth and Synapse Development of Both Vertebrate and Invertebrate Central Neurons

Mersman

Zaidi

Syed

et al. 2020

Front. Synaptic Neurosci.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Taurine Promotes Neurite Outgrowth and Synapse Development of Both Vertebrate and Invertebrate Central Neurons

Mersman

Zaidi

Syed

et al. 2020

Front. Synaptic Neurosci.

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“…Excitation was ascribed to activation of Na + -channels [3,37]. By using molecular biological techniques the GABA A receptor of Lymnaea has been cloned, and a 35-47 per cent identity with vertebrate ligand gated Cl --channel receptor subunits was found [7]. Together with pharmacological characteristics [26,34] it indicates similarities, but also some differences between vertebrate and invertebrate GABA receptors.…”

Section: Discussionmentioning

confidence: 99%

Cadmium ions modulate GABA induced currents in molluscan neurons

Molnár¹,

Győri²,

Salánki³

et al. 2002

Acta Biologica Hungarica

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The effect of Cd2+, as one of the most widespread toxic environmental pollutants, was studied on gamma-aminobutyric acid (GABA) evoked responses of identified neurons in the central nervous system of the pond snail, LYmnaea stagnalis L. (Gastropoda). In the experiments, the modulation of the action of GABA both on neuronal activity (current clamp recording) and on the a GABA activated membrane Cl- current (voltage clamp studies) has been shown. It was found that: 1. GABA could evoked three different various types of response in GABA sensitive neurons: i) hyperpolarization with strong inhibition of ongoing spike activity, ii) short depolarization with an increase of spike the activity, iii) biphasic respone with a short excitation followed by a more prolonged long inhibition. 2. In low-Cl- solution the inhibitory action of GABA was reduced or eliminated, but the excitatory one was not or only moderately affected. 3. CdCl2 inhibited the GABA evoked hyperpolarization, but left intact or only slightly reduced the excitation evoked by GABA. 4. The inward Cl- current evoked by GABA at a -75 mV holding potential was slightly augmented in the presence of I micromol/l Cd2+, but was reduced or blocked at higher cadmium concentrations. The effect of Cd2+ was concentration and time dependent. 5. Parallel with reducing the GABA evoked current, cadmium increased both the time to peak and the half inactivation time of the current. 6. CdCl2 alone, in 50 micromol/l concentration, induced a 1-2 nA inward current. The blocking effect of cadmium on GABA activated inhibitory processes can be an important component of the neuro-toxic effects of this heavy metal ion.

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“…We attempted to confirm results obtained with ISGV and MUS with PTX, a reagent that blocks ionotropic Cl 2 channels (Darlison et al, 1993;Zhorov and Bregestovski, 2000;Jing et al, 2003;Olsen, 2006). We also manipulated the bath Cl 2 concentrations (Fig.…”

Section: Pharmacological Analysis Of Gabaergic Activitymentioning

confidence: 96%

GABA is an inhibitory neurotransmitter in the neural circuit regulating metamorphosis in a marine snail

Biscocho

Cook

Long

et al. 2018

Developmental Neurobiology

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The marine mud snail, Tritia (=Ilyanassa) obsoleta, displays a biphasic life cycle. During the initial phase of early development, embryos hatch from benthic egg capsules to become weakly swimming veliger larvae. In the second phase, adult T. obsoleta are facultative carnivores and major agents of community disturbance. Metamorphosis is the irreversible developmental event that links these two life history stages. When physiologically competent, larvae can respond to appropriate environmental cues by settling onto their mudflat habitat and transforming themselves into miniature adult snails. Two neurotransmitters-serotonin and nitric oxide-have opposing effects on the metamorphic process in this species. In multiple other species of gastropod and bivalve molluscs, a third neurotransmitter, the classically inhibitory compound γ-aminobutyric acid (GABA), can induce settlement or metamorphosis upon external application to competent larvae. In this situation, GABA is presumed to mimic the action of ligands from the juvenile environment that bind to larval chemosensory receptors and activate the metamorphic pathway. Results of our experiments contradict this commonly reported action of GABA on molluscan larvae. External application of GABA to competent larvae of T. obsoleta elicited no response, but instead attenuated the action of serotonin (5-HT), a metamorphic inducer. Our investigations into the responses of larval T. obsoleta to multiple GABAergic reagents support our hypothesis that GABA functions internally as a neurotransmitter in the pathway that controls the initiation of metamorphosis. Our results also suggest that GABA acts directly on or downstream from serotonergic neurons to regulate the metamorphosis-inducing effects of this neurotransmitter. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 736-753, 2018.

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Molluscan ligand-gated ion-channel receptors

Cited by 10 publications

References 64 publications

Taurine Promotes Neurite Outgrowth and Synapse Development of Both Vertebrate and Invertebrate Central Neurons

Taurine Promotes Neurite Outgrowth and Synapse Development of Both Vertebrate and Invertebrate Central Neurons

Cadmium ions modulate GABA induced currents in molluscan neurons

GABA is an inhibitory neurotransmitter in the neural circuit regulating metamorphosis in a marine snail

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