Molluscicidal Triterpenoid Glycosides of <i>Dialium guineense</i>

Odukoya, Onatolu; Houghton, Peter J.; Adelusi, Adekunle Ajayi; Omogbai, Eric K. I.; Sanderson, Lisa; Whitfield, P. J.

doi:10.1021/np9604137

Cited by 11 publications

(7 citation statements)

References 13 publications

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“…(Leguminosae) has no significant antimalarial activity in our study except the dichloromethane extract with a moderate activity (IC 50 = 42.1 g/ml) and the total aqueous extract with a low activity (IC 50 = 65.5 g/ml). Odukoya et al (1996) have already reported the molluscicidal activity of the fruits and leaves due to triterpenoid glycosides.…”

Section: Dialium Guineensementioning

confidence: 99%

In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria

Béro

Ganfon

Jonville

et al. 2009

Journal of Ethnopharmacology

133

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Section: Dialium Guineensementioning

confidence: 99%

In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria

Béro

Ganfon

Jonville

et al. 2009

Journal of Ethnopharmacology

133

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“…Partial hydrolysis of polyfoliolide A (1): Compound 1 (1.5 mg) was treated with 5 mg of oxalic acid in 1 mL of MeOH-H 2 O (1 : 1) at 60 8C with reaction monitoring by TLC. After 30 h, the reaction mixture was extracted with EtOAc (3 10 mL) and the EtOAc-soluble fraction purified by normal phase PTLC with the solvent system n-hexane/EtOAc (75 : 25) to yield a solid (0.6 mg), whose spectral data ( 1 H-, 13 C-NMR and MS) and [a] D were identical to those of 3-O-b-D-xylopyranosyloleanolic acid (6) [14], [15]. The aqueous phase was neutralized with saturated Na 2 CO 3 solution and concentrated to yield a white solid which on purification over normal phase PTLC using the solvent system EtOAc/n-BuOH/H 2 O (20 : 70 : 10) furnished the sugar galactose (0.…”

Section: Extraction and Isolation Of Compoundsmentioning

confidence: 99%

New Cytotoxic Oleanane Saponins from the Infructescences ofPolyscias amplifoliafrom the Madagascar Rainforest

Chaturvedula

Schilling²,

Miller³

et al. 2003

Planta med

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Bioassay-guided fractionation of an ethanolic extract of the infructescences of Polyscias amplifolia resulted in the isolation of two new oleanolic acid saponins, polyfoliolides A (1) and B (2), in addition to the two known saponins 3-O-beta-D-galactopyranosyloleanolic acid (3) and 3-O-beta-D-galactopyranosyl-(1-->4)-beta-D-galactopyranosyloleanolic acid (4). The structures of the two new compounds were established as 3-O-beta- D-galactopyranosyl-(1-->4)-beta-D-xylopyranosyloleanolic acid (1) and 3-O-beta-D-galactopyranosyl-(1-->4)-alpha-L-arabinopyranosyloleanolic acid (2) on the basis of extensive 1D and 2D NMR spectroscopic data interpretation and chemical conversions. All the isolated compounds showed weak cytotoxicity against A2780 human ovarian cancer cell line, with IC50 values in the range 6.7 to 10.8 microg/mL.

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“…Among the scientific documentations on DAG are its stem bark"s significant analgesic activity [15] , its astringent antifungal property [16] and its efficacy in treating nasopharyngeal infections. Also noteworthy, is the molluscidal effect of its fruit [17] .…”

Section: Introductionmentioning

confidence: 99%

Gastric and duodenal antiulcer effects of aqueous bark extract of Dialium guineense Wild. (Fabaceae) and the possible mechanisms in laboratory models

Agbaje¹,

Doe²

2015

J Phytopharmacol

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The plant Dialium guineense (DAG) has been claimed by local users, to be effective in the treatment of peptic ulcers, especially, when taken as an aqueous decoction. The present study assessed the antiulcer activity of the plant, as well as explored the possible mechanisms of action of the herbal drug, aside identifying some of the various phytoconstituents, which could be responsible for its antiulcer activity. Different ulcerogens (ethanol 99.9 %, indomethacin 50 mg/kg, cysteamine 400 mg/kg, glacial acetic acid) and the pylorus ligation-induced ulcers were used to induce acute and chronic ulcers, with doses of 100, 300 and 750 mg/kg DAG and the standard drugs relative to each model, while assessing drug activity through ulcer scoring and comparing it with both the negative and positive controls. The extract, which has an LD50 of 1584.89 mg/kg when administered intraperitoneally, recorded a significant (p<0.05) antiulcer effect in all the models used in the study. Similarly, in the pylorus-ligated group, DAG compared effectively with atropine (1 mg/kg) and ranitidine (100 mg/kg), the standard antagonists of the secretagogues- carbachol and histamine employed in the study. The herbal drug produced a significant reduction in gastric juice volume, as well as in the free and the total acidity. The results suggest that DAG possesses a significant antiulcer property through cytoprotective and antisecretory actions, and it could be projected that the presence of secondary metabolites such as tannins, saponins and flavonoids could be responsible for its ulcer protective and healing property. The study therefore validates the folkloric use of DAG in the treatment of peptic ulcer.

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Molluscicidal Triterpenoid Glycosides of Dialium guineense

Cited by 11 publications

References 13 publications

In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria

In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria

New Cytotoxic Oleanane Saponins from the Infructescences ofPolyscias amplifoliafrom the Madagascar Rainforest

Gastric and duodenal antiulcer effects of aqueous bark extract of Dialium guineense Wild. (Fabaceae) and the possible mechanisms in laboratory models

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