Molluscum contagiosum in HIV-lnfected Patients

Petersen, Claus Leth; Gerstoft, Jan

doi:10.1159/000247492

Cited by 36 publications

(17 citation statements)

References 7 publications

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“…It is not known whether the infection of HIV-positive individuals with MC represents de novo infection, acquired by bodily contact, or the reactivation of a latent condition [42]. MC is capable of inducing the formation of a variety of circulating antibodies [53], but the paucity of B-lymphocytes and of neutrophils and the tendency of recurrence suggest that humoral immunity plays but a minor role in the local immune response.…”

Section: Follow-upmentioning

confidence: 99%

“…These eye-associated manifestations are most frequently encountered in young children [34], the usual sites of outbreak in immunocompetent adults being the external genitalia, the lower abdomen and the upper thigh [42]. The infection is spread by direct contact with infected individuals in showers and swimming pools [59] and on sexual contact [18].…”

Section: Introductionmentioning

confidence: 99%

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Evolution of HIV-1-related conjunctival molluscum contagiosum under HAART: report of a bilaterally manifesting case and literature review

Schulz

Sarra

Koerner

et al. 2004

Graefe's Arch Clin Exp Ophthalmol

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Purpose: To present a rare case of bilateral conjunctival molluscum contagiosum (MC) in an HIV-positive individual who had unilateral lesion excision before induction of highly active antiretroviral therapy (HAART), and to discuss the pathophysiological consequences of immune restoration. Methods: Case report: A 40-year-old male Caucasian presented with atypical, bilateral lesions of the limbal conjunctiva due to MC. Before the induction of HAART, nodules in the left eye were excised whilst the single lesion in the right eye was left untouched. Results: The clinical diagnosis of conjunctival MC was confirmed histopathologically. Six months after the induction of HAART, the untouched lesion (right eye) had regressed and there was pronounced local injection of the conjunctiva. MC lesions did not recur after excision (left eye), and signs of inflammation were absent. Conclusion: Conjunctival MC is rare and associated with immune deficiency. To the best of our knowledge, the presented case is the first reported instance of bilateral, multi-lesional MC of the conjunctiva in an HIVpositive patient undergoing HAART. Attention must be paid to the possible complications associated with the restoration of immunocompetence.

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Section: Follow-upmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evolution of HIV-1-related conjunctival molluscum contagiosum under HAART: report of a bilaterally manifesting case and literature review

Schulz

Sarra

Koerner

et al. 2004

Graefe's Arch Clin Exp Ophthalmol

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“…11). The surrounding dermis usually shows little or no inflammatory reaction, except in instances in which the lesion of MC ruptures and discharges molluscum bodies and horny material into the dermis [36].…”

Section: Molluscum (Ontagiosummentioning

confidence: 99%

Skin Diseases Associated with HIV Infection

Innocenzi

2001

Current Topics in Pathology

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“…Untreated papules in healthy people usually disappear spontaneously within several months, but in AIDS patients dense crops can persist, disfiguring infected patients. In HIV-infected people, rates of infection may be as high as 5 to 18% and as many as 33% of AIDS patients with CD4ϩ counts of less that 100 cells/mm 3 may be infected (Petersen and Gerstoft, 1992;Porter et al, 1992;Schwartz and Myskowski, 1992;Gottlieb and Myskowski, 1994).…”

mentioning

confidence: 99%

Mechanism of Inhibition of a Poxvirus Topoisomerase by the Marine Natural Product Sansalvamide A

et al. 1999

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At present no antiviral agents are available for treatment of infection by the pathogenic poxvirus molluscum contagiosum virus (MCV). Here we report the identification and characterization of an inhibitor active against the virus-encoded type-1 topoisomerase, an enzyme likely to be required for MCV replication. We screened a library of marine extracts and natural products from microorganisms using MCV topoisomerase assays in vitro. The cyclic depsipeptide sansalvamide A was found to inhibit topoisomerase-catalyzed DNA relaxation. Sansalvamide A was inactive against two other DNA-modifying enzymes tested as a counterscreen. Assays of discrete steps in the topoisomerase reaction cycle revealed that sansalvamide A inhibited DNA binding and thereby covalent complex formation, but not resealing of a DNA nick in a preformed covalent complex. Sansalvamide A also inhibits DNA binding by the isolated catalytic domain, thereby specifying the part of the protein sensitive to sansalvamide A. These data specify the mechanism by which sansalvamide A inhibits MCV topoisomerase. Cyclic depsipeptides related to sansalvamide A represent a potentially promising chemical family for development of anti-MCV agents.

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Molluscum contagiosum in HIV-lnfected Patients

Cited by 36 publications

References 7 publications

Evolution of HIV-1-related conjunctival molluscum contagiosum under HAART: report of a bilaterally manifesting case and literature review

Evolution of HIV-1-related conjunctival molluscum contagiosum under HAART: report of a bilaterally manifesting case and literature review

Skin Diseases Associated with HIV Infection

Mechanism of Inhibition of a Poxvirus Topoisomerase by the Marine Natural Product Sansalvamide A

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