Momilactones A and B Are α-Amylase and α-Glucosidase Inhibitors

Quan, Nguyen Van; Tran, Hoang-Dung; Xuan, Tran Dang; Ahmad, Ateeque; Dat, Tran Dang; Khanh, Tran Dang; Teschke, Rolf

doi:10.3390/molecules24030482

Cited by 53 publications

(82 citation statements)

References 57 publications

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“…Pure momilactones A, B, and tricin were isolated previously from rice husk by our laboratory [12]. Briefly, the ethyl acetate (EtOAc) extract of 7 kg Koshihikari husks was separated by open column chromatography over silica gel with the mobile phase as combinations of hexane and EtOAc.…”

Section: Reagents and Pure Compoundsmentioning

confidence: 99%

“…The information of rice samples is shown in Table 1, in which, all grains were purchased from Japan Agricultural Cooperatives (JA), Hiroshima, Japan. The extraction of rice grains was done followed methods described in previous studies [12,14]. In brief, except for the cooked Koshihikari sample, dried and powdered rice grains (200 g) were extracted with 300 mL of methanol for 1 week.…”

Section: Rice Grains and Sample Preparationsmentioning

confidence: 99%

“…Standard MA and MB were authenticated by reliable spectroscopic methods in previous studies [12][13][14]. The UPLC-ESI-MS system consisted of an LTQ Orbitrap XL mass spectrometer (Thermo Fisher Scientific, CA, USA) equipped with a source of electrospray ionization (ESI).…”

Section: Quantification Of Ma and Mb In Rice Grains By Uplc-esi-msmentioning

confidence: 99%

“…The total operation time was 15.1 min. The ESI condition and MS model was set up similar to the previous study [12,13]. The presence of MA and MB in rice grains was confirmed by comparing their extracted ion chromatograms (EIC) and mass spectra of samples with those of standard momilactones.…”

Section: Quantification Of Ma and Mb In Rice Grains By Uplc-esi-msmentioning

confidence: 99%

“…In previous studies, we discovered momilactones A (MA) and B (MB) as potential diabetic and obesity inhibitors in rice grain as well as in rice bran [12,13]. Their biological activities were also reviewed from literature containing allelopathic, antifungal, antibacterial, and anticancer activities [12]. However, the anti-skin-aging activity of MA and MB has not been studied so far.…”

Section: Introductionmentioning

confidence: 99%

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Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors

Quan

Thien²,

Khanh

et al. 2019

Foods

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We previously reported the inhibitory potentials of momilactones A (MA) and B (MB) against key enzymes related to type 2 diabetes and obesity. In this study, antioxidant and anti-skin-aging activities of MA and MB were investigated and compared with tricin, a well-known antioxidant and antiaging flavonoid in rice. MA, MB, and tricin were purified from rice husk by column chromatography and their biological activities were subsequently assayed by in vitro trials. The contents of MA, MB, and tricin of different commercial rice cultivars in Japan were quantified and confirmed by ultra-performance liquid chromatography-electrospray ionization-mass spectrometry (UPLC-ESI-MS) and high-performance liquid chromatography (HPLC) analyses. The antioxidant assays revealed a synergistic activity of the mixture MA and MB (MAB, 1:1, v/v). In addition, in 2,2'-azino-bis (ABTS) assay, IC 50 values of MAB (0.3 mg/mL) and tricin (0.3 mg/mL) was 4-fold and 9-fold greater than that of individual MB (1.3 mg/mL) or MA (2.8 mg/mL), respectively. The in vitro enzymatic assays on pancreatic elastase and tyrosinase indicated that MA and MB were potential to relief skin wrinkles and freckles. In detail, MA exerted higher inhibition on both enzymatic activities (30.9 and 37.6% for elastase and tyrosinase inhibition, respectively) than MB (18.5 and 12.6%) and MAB (32.0 and 19.7%) at a concentration of 2.0 mg/mL. Notably, MA and the mixture MAB exhibited stronger inhibitions on elastase and tyrosinase in comparison with tricin and vanillin. MA, MB, and tricin in rice are potential to develop cosmetics as well as supplements for skin aging treatments.

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Section: Reagents and Pure Compoundsmentioning

confidence: 99%

Section: Rice Grains and Sample Preparationsmentioning

confidence: 99%

Section: Quantification Of Ma and Mb In Rice Grains By Uplc-esi-msmentioning

confidence: 99%

Section: Quantification Of Ma and Mb In Rice Grains By Uplc-esi-msmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors

Quan

Thien²,

Khanh

et al. 2019

Foods

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The Inhibitory Activity of Natural Products to Xanthine Oxidase

Zhou

Huang

2023

Chemistry & Biodiversity

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The natural products have a new chemical structure and biological active diversity, so they are favored by scientific researchers. Gout is a high incidence and high-risk disease, and the current treatments are not satisfactory. Xanthine oxidase (XO) is a key enzyme responsible for the development and progression of various metabolic and oxidative stress-related diseases. Excessive activity of XO leads to elevated serum urate levels, which in turn leads to the development of hyperuricemia. This review mainly introduces the recent progress of the new research on the anti-gout activity of natural products that could provide new treatment methods for gout and information for the discovery and development of new antigout drugs.

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Advances in the natural α‐glucosidase inhibitors

Şöhretoğlu,

Renda,

Arroo

et al. 2023

eFood

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Abstractα‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a lowering effect on postprandial blood glucose and insulin levels. Natural products are a great source for the development of new AG inhibitory drug candidates. We aim to summarize advances in natural AG inhibitors according to their secondary metabolite groups in the last decade. Their mechanisms of action and structure–activity relationships will especially be discussed.

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Momilactones A and B Are α-Amylase and α-Glucosidase Inhibitors

Cited by 53 publications

References 57 publications

Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors

Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors

The Inhibitory Activity of Natural Products to Xanthine Oxidase

Advances in the natural α‐glucosidase inhibitors

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