Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats

Shih, Chun Chuan; Lin, Cheng-Wei; Lin, Weili; Wu, Jin‐Bin

doi:10.1016/j.jep.2009.02.039

Cited by 114 publications

(94 citation statements)

References 75 publications

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“…Insulin resistance was developed by the administration of a high-fructose diet. The treatment with bitter melon significantly ameliorated insulin resistance [84,85]. Moreover, the result of suppressing the elevated plasma TG and TC by bitter melon was consistent with previous studies in different animal models.…”

Section: Momordica Charantia (Bitter Melon)supporting

confidence: 89%

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Effect of Momordica charantia, Camellia sinensis and Cinnamon Species on Insulin Resistance

M¹

2014

Med Aromat Plants

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Section: Momordica Charantia (Bitter Melon)supporting

confidence: 89%

“…The fructose fed rats model is a model that mimics the human metabolic syndrome in many aspects, including hypertriglyceridemia, insulin resistance, and compensatory hyperinsulinemia [84][85][86]. Insulin resistance was developed by the administration of a high-fructose diet.…”

Section: Momordica Charantia (Bitter Melon)mentioning

confidence: 99%

Effect of Momordica charantia, Camellia sinensis and Cinnamon Species on Insulin Resistance

M¹

2014

Med Aromat Plants

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“…Unlike lipodystrophic conditions, obesity is a common health problem connected with a derangement of adipokines, particularly leptin and adiponectin, which possibly creates an imbalanced state between various oxidants and the body's detoxifying system with one consequence being the development of malignancies. [125]. Similarly, dietary conjugated linoleic acid supplementation has been shown to reduce the levels of leptin and increase the mRNA expression of adiponectin in the adipose tissue of obese rats [126].…”

Section: Preclinical Studies Of Both Leptin and Adiponectin In Relatimentioning

confidence: 99%

Obesity and breast cancer: status of leptin and adiponectin in pathological processes

Großmann

Ray

Nkhata

et al. 2010

Cancer Metastasis Rev

161

108

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It is well recognized that obesity increases the risk of various cancers, including breast malignancies in postmenopausal women. Furthermore, obesity may adversely affect tumor progression, metastasis, and overall prognosis in both pre- and postmenopausal women with breast cancer. However, the precise mechanism(s) through which obesity acts is/are still elusive and this relationship has been the subject of much investigation and speculation. Recently, adipose tissue and its associated cytokine-like proteins, adipokines, particularly leptin and adiponectin, have been investigated as mediators for the association of obesity with breast cancer. Higher circulating levels of leptin found in obese subjects could be a growth-enhancing factor as supported by in vitro and preclinical studies, whereas low adiponectin levels in obese women may be permissive for leptin's growth-promoting effects. These speculations are supported by in vitro studies which indicate that leptin promotes human breast cancer cell proliferation while adiponectin exhibits anti-proliferative actions. Further, estrogen and its receptors have a definite impact on the response of human breast cancer cell lines to leptin and adiponectin. More in-depth studies are needed to provide additional and precise links between the in vivo development of breast cancer and the balance of adiponectin and leptin.

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“…Most peoples favored to treat their disease by/via a natural agent/way [10,11]; for example for centuries Asian peoples used herbs to treat or prevent diabetes. In this case cinnamon, green tea, turmeric and bitter melon are good examples [12][13][14][15]. Previous studies have shown that 1-6 g/day cinnamon powder intake reduces blood glucose, total cholesterol and LDL-Cholesterol in human [16].…”

Section: Introductionmentioning

confidence: 99%

Hydro-Alcoholic Cinnamon Extract, Enhances Glucose Transporter Isotype-4 Translocation from Intracellular Compartments into the Cytoplasmic Membrane of C2C12 Myotubes

et al. 2012

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Cinnamon has been used as an anti-diabetic agent for centuries but only in recent few years its mechanism of action has been under investigation. Previous studies showed that cinnamon might exert its anti-diabetic effect via increasing glucose transporter isotype-4 (GLUT4) gene and glycoprotein contents in fat cells. To study if hydro-alcoholic cinnamon extract (HACE) enhances GLUT4 translocation from intracellular compartments of nuclear or endoplasmic reticulum membranes (N/ER) into the cytoplasmic membrane (CM). C2C12 myoblastic cell line were seeded in DMEM plus 20 % FBS and differentiated to myotubes using 2 % horse serum. After myotubes formation, 100 or 1,000 lg/ml HACE, as intervention, and as control 1 % DMSO were added for 3 h. Cells were washed and homogenized followed by ultracentrifuge fractionation, protein separation by SDS-PAGE and GLUT4 detection using semi-quantitative Western blotting. Data analysis was done by two-independent samples t test for comparison of mean ± SD of GLUT4 percent in categories. GLUT4 contents were higher in CM of groups 100 and 1,000 lg/ml HACE and lower in 1 % DMSO treated myotubes (CI = 0.95, P \ 0.05). For N/ER reverse results were obtained (CI = 0.95, P \ 0.05). As our results have shown HACE induces GLUT4 translocation from intra-cell into cell surface. We conclude that cinnamon maybe a choice of type-2 diabetes mellitus treatment because its extract enhances GLUT4 contents in CM where it facilitates glucose entrance into the cell. However it is necessary to trace the signaling pathways which are activated by HACE in muscular tissue.

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Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats

Cited by 114 publications

References 75 publications

Effect of Momordica charantia, Camellia sinensis and Cinnamon Species on Insulin Resistance

Effect of Momordica charantia, Camellia sinensis and Cinnamon Species on Insulin Resistance

Obesity and breast cancer: status of leptin and adiponectin in pathological processes

Hydro-Alcoholic Cinnamon Extract, Enhances Glucose Transporter Isotype-4 Translocation from Intracellular Compartments into the Cytoplasmic Membrane of C2C12 Myotubes

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