Monascus pilosus-fermented black soybean inhibits lipid accumulation in adipocytes and in high-fat diet-induced obese mice

Lee, Young Sil; Choi, Bong Keun; Lee, Hae Jin; Lee, Dong Ryung; Cheng, Jinhua; Lee, Won Keun; Yang, Seung Hwan; Suh, Joo Won

doi:10.1016/s1995-7645(14)60330-8

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…Yang et al [40] demonstrated that weight loss herbal intervention therapy (W-LHIT) reduced body weight, without suppression of appetite, in obese mice, by significantly increasing the gene expression of Pparg (peroxisome proliferator activated receptor gamma) and Fabp4 (fatty acid binding protein 4) epdidymal fat tissues. In contrast, Lee et al [41] Monascus pilosus-fermented black soybean inhibits lipid accumulation in adipocytes and in high-fat diet-induced obese mice, but significantly lower gene expression of adipogenesis-related genes like peroxisome proliferator-activated receptor gamma (Pparg) and fatty acid-binding protein 4 (Fabp4). Kim et al [42] showed that anti-obesity effect of Solidago virgaaurea extract in high-fat diet-fed SD rat was associated with decreased acetyl-CoA carboxylase, fatty acid synthase, and Fabp4.…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice

et al. 2019

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Spirulina platensis is a blue-green algae with potential anti-obesity effects. In this study, the anti-obesity effects of whole Spirulina platensis (WSP), Spirulina platensis protein (SPP) and Spirulina platensis protein hydrolysate (SPPH) were compared in high-fat diet fed mice, and the potential acting mechanism of SPPH was also investigated. Totally, SPPH exhibited good anti-obesity effects (reducing 39.8%±9.7% of body weight), lowering 23.8%±1.6% of serum glucose, decreasing 20.8%±1.4% of total cholesterol, while positive drug Simvastatin had the corresponding values: 8.3%±4.6%, 24.8%±1.9% and -2.1%±0.2%, respectively. Subsequently, PCR array was used to conduct gene expression analysis in brain and liver tissues of SPPH-treated mice, which displayed distinctly different expression pattern. The most markedly changed genes included: Acadm (-34.7 fold), Gcg (2.5 fold), Adra2b (2 fold) and Ghsr (2 fold) in brain; Retn (39 fold), Fabp4 (15.5 fold), Ppard (6 fold) and Slc27a1 (5.4 fold) in liver. Further network analysis demonstrated that the significantly expressed genes in brain and liver tissues were mapped into an interacting network, suggesting a modulatory effect on brain-liver axis, major pathways were involved in the axis: PPAR, adipocytokine, AMPK, non-alcoholic fatty liver disease and MAPK. This study showed that Spirulina platensis protein hydrolysate possessed anti-obesity effect in mice.

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Section: Discussionmentioning

confidence: 99%

Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice

et al. 2019

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“…As well as, significantly suppressed the major signaling transcriptional protein PPARγ, CEBPα, and aP2 expression level. Similar studies have shown that fermented soybean can significantly suppressed the protein level due to the high amount of bioactive ingredients (isoflavones) (Lee et al, ). In our study, we hypothesized that aglycones form of isoflavones and metabolites monacolin K may have anti‐adipogenesis activity by the STAT3/PPARγ/CEBPα signaling pathways.…”

Section: Resultsmentioning

confidence: 71%

Fermentation of soybean hull byMonascus pilosusand elucidation of its related molecular mechanism involved in the inhibition of lipid accumulation. An in sílico and in vitro approach

et al. 2017

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Soybean fermentation had been done over the years in order to increase its nutritional value. In order to that, our present study was focused on the fermentation of soybean hull (SH) by Monascus pilosus KCCM 60084 to enhance the secondary metabolite monacolin K and produce isoflavones such as daidzein and genistein (phytoestrogens). These isoflavones have effect on reducing cholesterol level, anticancer, and anti‐osteophorosis. Furthermore, the anti‐adipogenesis effect of fermented soybean hull (FSH) and nonfermented soybean hull (NFSH) was investigated by evaluating the molecular signaling at in vitro level (on 3T3‐L1 preadipocyte) as well as by the in sílico study. Results found that FSH had effect on the reduction of lipid accumulation without exerting any cytotoxicity compared with NFSH at cellular level at 100 µg/mL. In addition, we noticed that it significantly downregulated the mRNA levels of adipogenic transcriptional genes including jak2, STAT3, CEBPα, PPARγ, CEBPβ, and aP2 at same concentration as well as suppressed the protein expression p‐STAT3, PPARγ, CEBPα, and aP2. Also, molecular docking studies show that monacolin K, daidzein, and genistein interact with PPARγ reducing lipid accumulation highly than NFSH. We hypothesized that the newly produced isoflavones such as daidzein and genistein and the high amount of secondary metabolite monacolin K conjointly work on reducing lipid accumulation in adipocyte mature cells. Practical applications Soybean product had been used as a food along to functional food for its nutritional value. During the processing of this product the soybean hull (SH) is removed and discarded, since the used is high being a constant problem for soybean processing industries. In this study, we found a possible use for this SH which include its fermentation by Monascus pilosus KCCM 60084. This process gives as a result the transformation of SH metabolite and Isoflavones content increasing the possible uses of SH as a functional food or supplement since exhibits lower toxicity than nonfermented SH. In addition, SH in vitro effect was enhanced after fermentation suggesting a possible a possible preventive or therapeutic use for obesity. The results in this study, not only give us a new process option for soybean hull, but also shown that this fermentation increase its anti‐lipogenic effect.

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“…Previous studies show that fermented soybean hull, Monascus pilosus -fermented black soybean extracts, and Lactobacillus paracasei subsp. paracasei NTU101-fermented tea can reduce the proliferation of 3T3-L1 cells and inhibit lipid accumulation in the 3T3-L1 cell [ 29 , 30 , 31 ]. These results show that fermented plants administration can reduce the proliferation of 3T3-L1 cells and inhibit lipid accumulation.…”

Section: Discussionmentioning

confidence: 99%

The Anti-Obesity Effects of Lemon Fermented Products in 3T3-L1 Preadipocytes and in a Rat Model with High-Calorie Diet-Induced Obesity

Huang

Hou

et al. 2021

Nutrients

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Lemon (Citrus limon) has antioxidant, immunoregulatory, and blood lipid-lowering properties. This study aimed to determine the effect of the lemon fermented product (LFP) which is lemon fermented with Lactobacillus OPC1 to prevent obesity. The inhibition of lipid accumulation in 3T3-L1 adipocytes is examined using a Wistar rat model fed a high-fat diet to verify the anti-obesity efficacy and mechanism of LFP. Here, it was observed that LFP reduced cell proliferation and inhibited the lipid accumulation (8.3%) of 3T3-L1 adipocytes. Additionally, LFP reduced body weight (9.7%) and fat tissue weight (25.7%) of rats; reduced serum TG (17.0%), FFA (17.9%), glucose (29.3%) and ketone body (6.8%); and increased serum HDL-C (17.6%) and lipase activity (17.8%). LFP regulated the mRNA expression of genes related to lipid metabolism (PPARγ, C/EBPα, SREBP-1c, HSL, ATGL, FAS, and AMPK). Therefore, LFP reduces body weight and lipid accumulation by regulating the mRNA expression of genes related to lipid metabolism. Overall, our results implicate LFP as a potential dietary supplement for the prevention of obesity.

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Monascus pilosus-fermented black soybean inhibits lipid accumulation in adipocytes and in high-fat diet-induced obese mice

Abstract: These results suggest that the anti-obesity effects of MFBS are elicited by regulating the expression of adipogenesis-related genes in adipocytes and WAT of HFD-induced obese mice.

Cited by 12 publications

References 28 publications

Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice

Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice

Fermentation of soybean hull byMonascus pilosusand elucidation of its related molecular mechanism involved in the inhibition of lipid accumulation. An in sílico and in vitro approach

The Anti-Obesity Effects of Lemon Fermented Products in 3T3-L1 Preadipocytes and in a Rat Model with High-Calorie Diet-Induced Obesity

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