Moniliformin, a mycotoxin from Fusarium fusarioides

Rabie, C. J.; Lübben, A.; Louw, Abraham I.; Rathbone, Elner B.; Steyn, Pieter S.; Vleggaar, Robert

doi:10.1021/jf60216a011

Cited by 45 publications

(17 citation statements)

References 8 publications

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“…These two Fusarium species are common corn pathogens in most corn producing areas of the world [261]. Rable et al [262] have found that isolates of F. fusarioides obtained from millet, sorghum, peanuts, dried fish, and soil are all capable of producing MON. Nine toxic strains of F. avenaceum (Corda ex Fries) Sacc.…”

Section: Historical Perspective and Producing Fungal Speciesmentioning

confidence: 99%

Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

2015

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Abstract:Mycotoxins are secondary fungal metabolites, toxic to humans, animals and plants. Among the hundreds of known mycotoxins, aflatoxins, citrinin, patulin, penicillic acid, tenuazonic acid, ochratoxin A, cytochalasins, deoxynivalenol, fumonisins, fusarin C, fusaric acid, and zearalenone are considered the types that most contaminate cereal grain. The majority of the mycotoxins in these groups are produced by three fungal genera: Aspergillus, Penicillium and Fusarium. These metabolites primarily affect the seed quality, germination, viability, seedling vigour, growth of root and cleoptile. Additionally, since the fungi responsible for the production of these mycotoxins are often endophytes that infect and colonize living plant tissues, accumulation of mycotoxins in the plant tissues may at times be associated with development of plant disease symptoms. The presence of mycotoxins, even in the absence of disease symptoms, may still have subtle biological effects on the physiology of plants. Several studies highlight the toxic effects of mycotoxins on animals and cell lines but little is known about the mode of action of most of these metabolites on plant cells. The most important mycotoxins with phytotoxic effects and their producers in addition to their discovery are briefly outlined below and will be addressed in this article.

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Section: Historical Perspective and Producing Fungal Speciesmentioning

confidence: 99%

Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

2015

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“…Fusaproliferin can induce teratogenic effects, e.g., cephalic dichotomy, macrocephaly, and limb asymmetry, in chicken embryos (26). Moniliformin is a sodium or potassium salt of 1-hydroxycyclobut-1-ene-3,4-dione (4,24), which has been shown to be extremely toxic to animals such as ducklings, rats, mice, chickens, and swine (1,2,13).…”

mentioning

confidence: 99%

Production of Beauvericin, Moniliformin, Fusaproliferin, and Fumonisins B ₁ , B ₂ , and B ₃ by Fifteen Ex-Type Strains of Fusarium Species

Fotso¹,

Leslie

Smith³

2002

Appl Environ Microbiol

122

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Fifteen Fusarium species were analyzed by high-performance liquid chromatography for the production of six mycotoxins in corn grits cultures. Production of mycotoxins ranged from 66 to 2,500 g/kg for fumonisin B 1 , 0.6 to 1,500 g/g for moniliformin, 2.2 to 720 g/g for beauvericin, and 12 to 130 g/g for fusaproliferin. Fumonisin B 2 (360 g/kg) was produced by two species, fumonisin B 3 was not detected in any of the 15 species examined, and Fusarium bulbicola produced none of the six mycotoxins that we analyzed.

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“…(Lesley and Summerell, 2016), and thus moniliformin can occur in many cereals, fruits and vegetables. Furthermore, moniliformin is produced by isolates of Fusarium fusaroides from millet, sorghum, dried fish and peanuts (Rabie et al, 1978). In addition Fusarium species produce several other mycotoxins concomitantly, such as trichothecenes, zearalenone, Visagie et al, 2014a Aspergillus ochraceus Ciegler, 1972;El-Shanawany et al, 2005;Frisvad et al, 2004a;Garza et al, 1993;Northolt et al, 1979;Obana et al, 1995b;Visagie et al, 2014a Aspergillus ostianus Ciegler, 1972;Frisvad et al, 2004a;Namikoshi et al, 2003;Obana et al, 1995b; Frisvad et al, 2004a;Visagie et al, 2014a Aspergillus sclerotiorum Ciegler, 1972;Frisvad et al, 2004a;Kang and Kim, 2004;Kang et al, 2007;Obana et al, 1995b;Visagie et al, 2014a;Zheng et al, Bridge et al 1989;Bokhari and Flannigan, 1996;El-Banna et al, 1987;Frisvad and Filtenborg 1983;Frisvad et al, 2004b;Garza et al, 1993;Khaddor et al, 2007;Lund and Frisvad 1994;Mills et al, 1995a,b;Oh et al, 1998 Penicillium aurantiogriseum var.…”

Section: Moniliformin and Producing Microorganismsmentioning

confidence: 99%

“…Fusarium acuminatum Hussein et al, 1991;Logrieco et al, 1992;Rabie et al, 1982;Schütt et al, 1998 Hussein et al, 1991;Rabie et al, 1982 Fusarium fujikuroi (Bakane strains) Marasas et al, 1986Marasas et al, , 1991Schütt et al, 1998 Fusarium fusaroides Rabie et al, 1978Rabie et al, , 1982 Fotso et al, 2002;Schütt et al, 1998 (Fusarium moniliforme) 2 Cole Burmeister et al, 1979;Hussein et al, 1991;Marasas et al, 1986;Rabie et al, 1982;Tseng, 1993 Fusarium moniliforme var. subglutinans (Fusarium sacchari var.…”

Section: Fungal Species Referencesmentioning

confidence: 99%

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

Frisvad

2018

WMJ

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A very large number of filamentous fungi has been reported to produce the small lactone mycotoxins patulin, penicillic acid and moniliformin. Among the 167 reported fungal producers of patulin, only production by 29 species could be confirmed. Patulin is produced by 3 Aspergillus species, 3 Paecilomyces species, 22 Penicillium species from 7 sections of Penicillium, and one Xylaria species. Among 101 reported producers of penicillic acid, 48 species could produce this mycotoxin. Penicillic acid is produced by 23 species in section Aspergillus subgenus Circumdati section Circumdati, by Malbranchea aurantiaca and by 24 Penicillium species from 9 sections in Penicillium and one species that does not actually belong to Penicillium (P. megasporum). Among 40 reported producers of moniliformin, five species have been regarded as doubtful producers of this mycotoxin or are now regarded as taxonomic synonyms. Moniliformin is produced by 34 Fusarium species and one Penicillium species. All the accepted producers of patulin, penicillic acid and moniliformin were revised according to the new one fungus – one name nomenclatural system, and the most recently accepted taxonomy of the species.

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Moniliformin, a mycotoxin from Fusarium fusarioides

Cited by 45 publications

References 8 publications

Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

Production of Beauvericin, Moniliformin, Fusaproliferin, and Fumonisins B ₁ , B ₂ , and B ₃ by Fifteen Ex-Type Strains of Fusarium Species

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

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Moniliformin, a mycotoxin from Fusarium fusarioides

Cited by 45 publications

References 8 publications

Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

Production of Beauvericin, Moniliformin, Fusaproliferin, and Fumonisins B 1 , B 2 , and B 3 by Fifteen Ex-Type Strains of Fusarium Species

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

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Production of Beauvericin, Moniliformin, Fusaproliferin, and Fumonisins B ₁ , B ₂ , and B ₃ by Fifteen Ex-Type Strains of Fusarium Species