Monitoring arterial blood pressure during whole body hyperthermia

Kerner, Thoralf; Deja, Maria; Ahlers, Olaf; Hildebrandt, Bert; Dieing, Annette; Riess, Hanno; Wust, Peter; Gerlach, Herwig

doi:10.1034/j.1399-6576.2002.460514.x

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…In some cases, local hyperthermia at a temperature of 42 • to 43 • C for 30 to 60 min is used to treat brain tumor tissue in animals (Sminia et al, 1994). Such heat doses lead to hemorrhages and necrosis in the surrounding brain tissue with limited changes in whole-body physiology (Kerner et al, 2002). Local or regional heating of the brain is often associated with edema formation and cell injury (van der Zee, 1987;Sminia et al, 1994).…”

Section: 1421mentioning

confidence: 99%

Methods to Produce Brain Hyperthermia

Sharma

2005

CP Toxicology

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With the increase in global warming, the problems of hyperthermia have recently attracted world-wide medical attention. Deaths due to heat-related illnesses that have occurred in many human populations in recent years are now recognized as a great social and medical problem. Interestingly, the detailed mechanisms of hyperthermia and probable therapeutic measures have still not been worked out. Thus, good experimental models to simulate hyperthermia under clinical conditions are needed to expand our knowledge in the field and to develop suitable therapeutic strategies in the future. This unit describes an animal model to induce hyperthermia that is comparable to the clinical situation. The model will be useful for studying the effects of heat-related illnesses on various organs and systems. Because hyperthermia is associated with brain dysfunction, methods to assess some crucial parameters of brain injury, such as breakdown of the blood-brain barrier and brain edema formation, are also described.

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Section: 1421mentioning

confidence: 99%

Methods to Produce Brain Hyperthermia

Sharma

2005

CP Toxicology

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“…7.6 x 3.7 x 6.0 mm 18.0 x 7.9 x 9.7 mm 14.0 x 11.0 x 14.4 mm D294 7.9 x 5.9 x 6.4 mm 11.4 x 6.3 x 6.4 mm 23.0 x 10.0 x 15.8 mm Observed adverse effects during and following WBTT included hypotension, tachypnea, anorexia and skin lesions. In human medicine, it has been shown that while WBTT increases the heart rate, a drop in the systemic vascular resistance occurs during WBTT when the body temperature exceeds 40°C (Kerner et al, 2002), most likely due to alterations in thermal sensitivity of arterial baroreceptors and/or effects on the central nervous system (Haveman et al, 2004). The dopamine CRI in the dog of the present case successfully counteracted the hypotension.…”

Section: Discussionmentioning

confidence: 49%

Whole-body thermal therapy as adjuvant therapy to radiation in a dog with metastasized anal sac adenocarcinoma

Wylleman¹,

Kromhout²,

Benoît³

et al. 2021

VDT

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An eleven-year-old Galgo Espagnol was diagnosed with metastasized anal sac adenocarcinoma. The patient was enrolled into a clinical trial and underwent three “whole-body thermal therapy” (WBTT) sessions combined with four hypofractionated radiotherapy sessions during a ten-weeks’ time period. The medical device and corresponding treatment protocol were designed by ElmediX (ElmediX NV, Belgium). Air was injected at high speed in a treatment chamber and automatically regulated to reach and maintain a body temperature of 41.5°C for eight hours. Thermometry was ensured by temperature sensors placed in and on the patient. During four radiotherapy sessions, an external beam delivered hypofractionated doses of 6Gy on both the primary tumor and the metastatic lymph nodes. Clinical monitoring and assessment of quality of life confirmed that the WBTT sessions were well tolerated. Although burn wounds at pressure points occurred, prolonged severe adverse effects were not observed. Furthermore, the disease progression was deemed slower than the expected progression based on the literature.

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“…WBH is accompanied by a markedly hyperdynamic cardiovascular state, which can result in a drop in arterial blood pressure that is chiefly due to a substantial decrease of the peripheral vascular resistance [27,[30][31][32]. In order to guarantee sufficient perfusion of vital organs, the mean arterial blood pressure should be maintained above 50 mmHg during the entire treatment.…”

Section: Induction Of Wbhmentioning

confidence: 98%

Current status of radiant whole-body hyperthermia at temperatures >41.5°C and practical guidelines for the treatment of adults. The German ‘Interdisciplinary Working Group on Hyperthermia’

Hildebrandt

Hegewisch-Becker

Kerner

et al. 2005

International Journal of Hyperthermia

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The term 'extreme' whole-body hyperthermia (WBH) describes the procedure of raising a patients' body-core temperature to 41.5-42.0 degrees C for 60 min. WBH represents the only hyperthermia technique that enables systemic heat treatment in patients with disseminated malignancies and is, therefore, usually combined with systemic chemotherapy. Up to now, several WBH-approaches have proved to be safe and associated with acceptable toxicity rates when radiant heat devices are employed. Until the late 1990s, the use of radiant WBH was restricted to a few specialized treatment centres worldwide. During the last 5 years, a larger number of WBH-devices were put into operation particularly in Germany. As a result, a novel generation on phase II trials on chemotherapy and adjunctive WBH in patients with various malignancies has been completed. Based on the promising results observed herein, first multi-centric phase III-trials on chemotherapy +/- WBH have been initiated, with a considerable number of patients treated at German institutions. The authors are members of the 'Interdisciplinary Working Group for Hyperthermia' ('Interdisziplinäre Arbeitsgruppe Hyperthermie'), a sub-group of the German Cancer Society. They formulated these guidelines in order to standardize the WBH treatment procedure and supportive measures, to provide some uniformity in the selection of patients to be treated and to define criteria of a successful WBH-treatment. These recommendations may be helpful to ensure the quality of WBH performed at different institutions.

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Monitoring arterial blood pressure during whole body hyperthermia

Abstract: The mean arterial pressure and not the systolic and/or diastolic pressure should guide hemodynamic management during WBH. The sphygmomanometric technique is not recommended for use during hyperthermia.

Cited by 9 publications

References 31 publications

Methods to Produce Brain Hyperthermia

Methods to Produce Brain Hyperthermia

Whole-body thermal therapy as adjuvant therapy to radiation in a dog with metastasized anal sac adenocarcinoma

Current status of radiant whole-body hyperthermia at temperatures >41.5°C and practical guidelines for the treatment of adults. The German ‘Interdisciplinary Working Group on Hyperthermia’

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