Monitoring blood oxygenation changes due to acute pain stimuli using functional near-infrared spectroscopy (fNIRS)

Azar, Arezou Akbarian

doi:10.1109/iembs.2009.5334283

Cited by 2 publications

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“…In one study the temporal and spatial characteristics of somatosensory cortex activation was investigated; NIRS differentiated between mechanically painful and non-painful stimuli [ 44 ]. In another study a correlation was found between fNIRS signals and patients’ subjective acute pain levels [ 45 ]. NIRS was also used to visualize pain during painful procedures like in cardiac surgery [ 46 ] or arthroscopic shoulder surgery [ 47 ] and in migraineurs [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Increased cortical activation upon painful stimulation in fibromyalgia syndrome

et al. 2015

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BackgroundFibromyalgia syndrome (FMS) is a chronic condition characterized by widespread pain and associated symptoms. We investigated cerebral activation in FMS patients by functional near-infrared spectroscopy (fNIRS).MethodsTwo stimulation paradigms were applied: a) painful pressure stimulation at the dorsal forearm; b) verbal fluency test (VFT). We prospectively recruited 25 FMS patients, ten patients with unipolar major depression (MD) without pain, and 35 healthy controls. All patients underwent neurological examination and all subjects were investigated with questionnaires (pain, depression, FMS, empathy).ResultsFMS patients had lower pressure pain thresholds than patients with MD and controls (p < 0.001) and reported higher pain intensity (p < 0.001). Upon unilateral pressure pain stimulation fNIRS recordings revealed increased bilateral cortical activation in FMS patients compared to controls (p < 0.05). FMS patients also displayed a stronger contralateral activity over the dorsolateral prefrontal cortex in direct comparison to patients with MD (p < 0.05). While all three groups performed equally well in the VFT, a frontal deficit in cortical activation was only found in patients with depression (p < 0.05). Performance and cortical activation correlated negatively in FMS patients (p < 0.05) and positively in patients with MD (p < 0.05).ConclusionOur data give further evidence for altered central nervous processing in patients with FMS and the distinction between FMS and MD.Trial registrationISRCTN registry ID ISRCTN15015327 (24.09.2015).Electronic supplementary materialThe online version of this article (doi:10.1186/s12883-015-0472-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Increased cortical activation upon painful stimulation in fibromyalgia syndrome

et al. 2015

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Effects of Increasing Neuromuscular Electrical Stimulation Current Intensity on Cortical Sensorimotor Network Activation: A Time Domain fNIRS Study

Muthalib

Zucchelli

et al. 2015

PLoS ONE

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Neuroimaging studies have shown neuromuscular electrical stimulation (NMES)-evoked movements activate regions of the cortical sensorimotor network, including the primary sensorimotor cortex (SMC), premotor cortex (PMC), supplementary motor area (SMA), and secondary somatosensory area (S2), as well as regions of the prefrontal cortex (PFC) known to be involved in pain processing. The aim of this study, on nine healthy subjects, was to compare the cortical network activation profile and pain ratings during NMES of the right forearm wrist extensor muscles at increasing current intensities up to and slightly over the individual maximal tolerated intensity (MTI), and with reference to voluntary (VOL) wrist extension movements. By exploiting the capability of the multi-channel time domain functional near-infrared spectroscopy technique to relate depth information to the photon time-of-flight, the cortical and superficial oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin concentrations were estimated. The O2Hb and HHb maps obtained using the General Linear Model (NIRS-SPM) analysis method, showed that the VOL and NMES-evoked movements significantly increased activation (i.e., increase in O2Hb and corresponding decrease in HHb) in the cortical layer of the contralateral sensorimotor network (SMC, PMC/SMA, and S2). However, the level and area of contralateral sensorimotor network (including PFC) activation was significantly greater for NMES than VOL. Furthermore, there was greater bilateral sensorimotor network activation with the high NMES current intensities which corresponded with increased pain ratings. In conclusion, our findings suggest that greater bilateral sensorimotor network activation profile with high NMES current intensities could be in part attributable to increased attentional/pain processing and to increased bilateral sensorimotor integration in these cortical regions.

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Monitoring blood oxygenation changes due to acute pain stimuli using functional near-infrared spectroscopy (fNIRS)

Cited by 2 publications

References 0 publications

Increased cortical activation upon painful stimulation in fibromyalgia syndrome

Increased cortical activation upon painful stimulation in fibromyalgia syndrome

Effects of Increasing Neuromuscular Electrical Stimulation Current Intensity on Cortical Sensorimotor Network Activation: A Time Domain fNIRS Study

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