Monitoring changes in quality of life in patients with lung cancer under treatment with chemotherapy and co administration of zoledronic acid by using specialized questionnaires

Abstract

Background: Due to the severity of the primary disease in patients with lung cancer, quality of life (QoL) is often overlooked. Factors that form QoL should be taken in consideration when planning the appropriate treatment and determining therapy targets, because of the increasing frequency of bone metastasis leading to high levels of pain. Purpose of this study is to assess quality of life in patients with lung cancer, before and after treatment combined with zoledronic acid.Methods and materials: QoL was assessed in 80 patients (49 males-31 females), of which 45 developed bone metastasis. Prior and post treatment (with co administration of zoledronic acid) seven reliable scales: Pittsburgh Sleep Quality index (PSQI), Epworth Sleeping Scale (ess), Dyspnea Scale (ds), Fatigue Severity Scale (FSS), Brief Pain Inventory (BPI), Fact-G scale for sleep quality and EQ-5D for general health condition.Results: Statistically positive correlations were verified between PSQI-DS, PSQI-FSS, BPI-ESS, DS-FSS, DS-BPI and BPI-FSS (p<0,005) prior and post treatment. Patients sleep quality was improved, pain levels decreased and betterment in quality of life was marked (p<0,001). Although significant decrease in fatigue levels was observed (p<0,001) there has been an increase in dyspnea symptoms (p<0,001).Conclusions: Significant improvement was apparent when zoledronic acid was co administered in any treatment in patients with lung cancer. Sleep quality, fatigue and pain parameters also improved, with no positive impact on the symptoms of dyspnea.

Using the Fatigue Severity Scale to inform healthcare decision-making in multiple sclerosis: mapping to three quality-adjusted life-year measures (EQ-5D-3L, SF-6D, MSIS-8D)

“…According to the Oxford Health Economics Research Centre’s Mapping Database, last updated in April 2019 [37], no previous published studies have attempted mapping from the FSS. In addition, we have found no previous studies which have investigated correlations between the FSS and the SF-6D or the FSS and the MSIS-8D, and just two which have explored the relationship between the FSS and the EQ-5D [38, 39]. Rosa et al [39] correlated FSS total scores with participants’ scores on the EQ-5D visual analogue scale, rather than with the EQ-5D HSUVs that are relevant for mapping, and Tremmas et al [38] found no statistically significant correlation between the FSS and EQ-5D scores of people with lung cancer.…”

Staged versus conventional nursing for patients receiving chemotherapy for advanced non-small cell lung cancer: a before and after study

“…The co-administration of conventional chemotherapeutic agents and novel drugs provides an option. Several previously published studies have reported that this can improve the QoL of NSCLC patients (23,25,27). Adamowicz et al also proposed that the level of patient knowledge of cancer was associated with QoL (21).…”

“…Although graded nursing did not exhibit any significant impact on the incidence of adverse events, it still significantly improved the QoL of NSCLC patients in our study. There are a number of previously published studies exploring efficient measurements to improve the QoL of NSCLC patients (19)(20)(21)(22)(23)(24)(25)(26)(27). The co-administration of conventional chemotherapeutic agents and novel drugs provides an option.…”

A Secure Occupational Therapy Framework for Monitoring Cancer Patients’ Quality of Life

“…In 2018, 1.74 million individuals were diagnosed with cancer in the USA alone Both cancer itself and cancer treatments severely affect a patient’s quality of life and daily functioning [1,2], for example through muscle stiffness [3], joint pain, a decrease in bone density and muscle endurance, weight loss, nausea and vomiting, neurological impairments, decreased stamina, loss of range of motion, changes in sensation and cognition [4], cardiopulmonary dysfunction, deconditioning, difficulty with mobility and daily activities, edema, reproduction and sexuality difficulties, communication impairments, memory and attention problems, and psychological effects, such as depression, fear, anxiety, and post-traumatic stress disorder [2]. However, researchers have found that through early detection and advancements in treatment options, the survival rate can be improved [3,4].…”

“…These items are of great concern to family and loved ones who are also facing a heavy mental burden that is often overlooked by caregivers. The severe side effects of cancer-treatment plans negatively affect the quality of life (QoL) and limit the body functionality of cancer patients [1]. Many of them experience difficulty in retaining their former physiological status, which usually impacts their activities of daily living (ADL), and returning to normal social, education, or work-related activities [6].…”