Monitoring chemotherapeutic response in RIF-1 tumors by single-quantum and triple-quantum-filtered 23Na MRI, 1H diffusion-weighted MRI and PET imaging

Babsky, Andriy M.; Zhang, Hong; Hekmatyar, S. K.; Hutchins, Gary D.; Bansal, Navin

doi:10.1016/j.mri.2006.11.004

Cited by 31 publications

(31 citation statements)

References 14 publications

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“…Although the following studies were not performed on humans but on rats or mice in vivo , it is useful to mention these here as they represent important preliminary work in preparation for potential human applications on cancer and chemotherapeutic response assessment [84,220,221]. The goal of cancer therapy is to eliminate neoplastic cells, but the assessment of the therapeutic efficiency in vivo may be difficult.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…Babsky et al [220] implanted fibrosarcoma (RIF-1) tumors in mice and monitored the effects of 5-fluorouracil (5FU) treatment with proton DWI, single pulse and TQF sodium MRI and also PET for measuring fluorodeoxyglucose (FDG) uptake in the tumor. Tumor volumes significantly decreased in treated animals and slightly increased in control tumors one, two, and three days post-treatment.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Sodium MRI: Methods and applications

Madelin

Lee

Regatte

et al. 2014

Progress in Nuclear Magnetic Resonance Spectroscopy

190

209

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Sodium NMR spectroscopy and MRI have become popular in recent years through the increased availability of high-field MRI scanners, advanced scanner hardware and improved methodology. Sodium MRI is being evaluated for stroke and tumor detection, for breast cancer studies, and for the assessment of osteoarthritis and muscle and kidney functions, to name just a few. In this article, we aim to present an up-to-date review of the theoretical background, the methodology, the challenges and limitations, and current and potential new applications of sodium MRI.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Sodium MRI: Methods and applications

Madelin

Lee

Regatte

et al. 2014

Progress in Nuclear Magnetic Resonance Spectroscopy

190

209

View full text Add to dashboard Cite

show abstract

“…Sodium alterations in untreated tumors have been previously detected (13,15,21–25). Weak sodium MR signals usually observed in vivo dictate selecting a low resolution matrix for sodium imaging.…”

Section: Introductionmentioning

confidence: 96%

In vivo magnetic resonance imaging of sodium and diffusion in rat glioma at 21.1 T

Schepkin

Bejarano

Morgan

et al. 2011

Magnetic Resonance in Med

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Sodium and diffusion MRI in intracranial rat 9L gliomas were evaluated over 6–8 days using the advanced sensitivity of sodium MRI at 21.1T. Glioma doubling time was 2.4–2.6 days. Glioma sodium signal was detected using the ultra-short echo time of 0.15 ms. The high resolution 3D sodium MRI with pixels of 0.125 µL allowed for minimizing a partial volume effect often relevant to the MRI of low intensity signals. Tumor sodium and diffusion MRI were evaluated for two separate sub-clones of 9L cells with different resistance to 1,3 bis(2-chloroethyl)-1-nitrosurea (BCNU) detected by pre-surgery assays. In vivo, after implantation, resistant 9L cells created tumors with significantly reduced sodium concentrations (57±3 mM) compared to non-resistant 9L cells (78±3 mM). The corresponding differences in diffusion were less, but also statistically significant. During tumor progression, an increase of glioma sodium concentration was observed in both cell types with a rate of 2.4–5.8 %/day relative to normal brain. Tumor diffusion was not significantly changed at this time, indicative of no alterations in glioma cellularity. Thus, changes in sodium during tumor progression reflect increasing intracellular sodium concentration and mounting metabolic stress. These experiments also demonstrate an enhanced sensitivity of sodium MRI to reflect tumor cell resistance.

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“…(Zhao et al , 1996). Transient dose-dependent increases of ADC after therapy were also observed in mouse gliomas after administration of 1,3-bis(2-chloroethyl)-1-nitrosourea (Chenevert et al , 1997), prostate tumors treated with docetaxel (Jennings et al , 2002), breast tumors treated with paclitaxel (Galons et al , 1999) and RIF-1 tumors treated with cyclophosphamide and 5-fluorouracil (Babsky et al , 2007; Babsky et al , 2005), and in a mouse model of Ewing sarcoma treated with treosulfan (Reichardt et al , 2009). Tumor ADC values were found to increase within the first 24 to 72 hours after treatment and plateau or decrease at later times.…”

Section: 0 Diffusion-weighted Mri (Dwi)mentioning

confidence: 99%

High-field small animal magnetic resonance oncology studies

et al. 2013

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This review focuses on the applications of high magnetic field magnetic resonance imaging (MRI) and spectroscopy (MRS) to cancer studies in small animals. High field MRI can provide information about tumor physiology, the microenvironment, metabolism, vascularity and cellularity. Such studies are invaluable for understanding tumor growth and proliferation, response to treatment and drug development. The MR techniques reviewed here include 1H, 31P, Chemical Exchange Saturation Transfer (CEST) imaging, and hyperpolarized 13C MR spectroscopy as well as diffusion-weighted, Blood Oxygen Level Dependent (BOLD) contrast imaging, and dynamic contrast-enhanced MR imaging. These methods have been proven effective in animal studies and are highly relevant to human clinical studies.

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Monitoring chemotherapeutic response in RIF-1 tumors by single-quantum and triple-quantum-filtered 23Na MRI, 1H diffusion-weighted MRI and PET imaging

Cited by 31 publications

References 14 publications

Sodium MRI: Methods and applications

Sodium MRI: Methods and applications

In vivo magnetic resonance imaging of sodium and diffusion in rat glioma at 21.1 T

High-field small animal magnetic resonance oncology studies

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